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Genetic predisposition to higher blood pressure increases coronary artery disease risk

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Genetic predisposition to higher blood pressure increases coronary artery disease risk. / Lieb, Wolfgang; Jansen, Henning; Loley, Christina; Pencina, Michael J; Nelson, Christopher P; Newton-Cheh, Christopher; Kathiresan, Sekar; Reilly, Muredach P; Assimes, Themistocles L; Boerwinkle, Eric; Hall, Alistair S; Hengstenberg, Christian; Laaksonen, Reijo; McPherson, Ruth; Thorsteinsdottir, Unnur; Ziegler, Andreas; Peters, Annette; Thompson, John R; König, Inke R; Erdmann, Jeanette; Samani, Nilesh J; Vasan, Ramachandran S; Schunkert, Heribert; CARDIoGRAM Consortium.

In: HYPERTENSION, Vol. 61, No. 5, 05.2013, p. 995-1001.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lieb, W, Jansen, H, Loley, C, Pencina, MJ, Nelson, CP, Newton-Cheh, C, Kathiresan, S, Reilly, MP, Assimes, TL, Boerwinkle, E, Hall, AS, Hengstenberg, C, Laaksonen, R, McPherson, R, Thorsteinsdottir, U, Ziegler, A, Peters, A, Thompson, JR, König, IR, Erdmann, J, Samani, NJ, Vasan, RS, Schunkert, H & CARDIoGRAM Consortium 2013, 'Genetic predisposition to higher blood pressure increases coronary artery disease risk', HYPERTENSION, vol. 61, no. 5, pp. 995-1001. https://doi.org/10.1161/HYPERTENSIONAHA.111.00275

APA

Lieb, W., Jansen, H., Loley, C., Pencina, M. J., Nelson, C. P., Newton-Cheh, C., Kathiresan, S., Reilly, M. P., Assimes, T. L., Boerwinkle, E., Hall, A. S., Hengstenberg, C., Laaksonen, R., McPherson, R., Thorsteinsdottir, U., Ziegler, A., Peters, A., Thompson, J. R., König, I. R., ... CARDIoGRAM Consortium (2013). Genetic predisposition to higher blood pressure increases coronary artery disease risk. HYPERTENSION, 61(5), 995-1001. https://doi.org/10.1161/HYPERTENSIONAHA.111.00275

Vancouver

Lieb W, Jansen H, Loley C, Pencina MJ, Nelson CP, Newton-Cheh C et al. Genetic predisposition to higher blood pressure increases coronary artery disease risk. HYPERTENSION. 2013 May;61(5):995-1001. https://doi.org/10.1161/HYPERTENSIONAHA.111.00275

Bibtex

@article{17a3ebf337e74b3d81a984a923395097,
title = "Genetic predisposition to higher blood pressure increases coronary artery disease risk",
abstract = "Hypertension is a risk factor for coronary artery disease. Recent genome-wide association studies have identified 30 genetic variants associated with higher blood pressure at genome-wide significance (P<5 × 10(-8)). If elevated blood pressure is a causative factor for coronary artery disease, these variants should also increase coronary artery disease risk. Analyzing genome-wide association data from 22 233 coronary artery disease cases and 64 762 controls, we observed in the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) consortium that 88% of these blood pressure-associated polymorphisms were likewise positively associated with coronary artery disease, that is, they had an odds ratio >1 for coronary artery disease, a proportion much higher than expected by chance (P=4 × 10(-5)). The average relative coronary artery disease risk increase per each of the multiple blood pressure-raising alleles observed in the consortium was 3.0% for systolic blood pressure-associated polymorphisms (95% confidence interval, 1.8%-4.3%) and 2.9% for diastolic blood pressure-associated polymorphisms (95% confidence interval, 1.7%-4.1%). In substudies, individuals carrying most systolic blood pressure- and diastolic blood pressure-related risk alleles (top quintile of a genetic risk score distribution) had 70% (95% confidence interval, 50%-94%) and 59% (95% confidence interval, 40%-81%) higher odds of having coronary artery disease, respectively, as compared with individuals in the bottom quintile. In conclusion, most blood pressure-associated polymorphisms also confer an increased risk for coronary artery disease. These findings are consistent with a causal relationship of increasing blood pressure to coronary artery disease. Genetic variants primarily affecting blood pressure contribute to the genetic basis of coronary artery disease.",
keywords = "Adult, Aged, Alleles, Blood Pressure/genetics, Case-Control Studies, Coronary Artery Disease/epidemiology, Female, Genetic Predisposition to Disease/genetics, Genome-Wide Association Study, Humans, Hypertension/genetics, Male, Middle Aged, Polymorphism, Single Nucleotide/genetics, Risk Factors",
author = "Wolfgang Lieb and Henning Jansen and Christina Loley and Pencina, {Michael J} and Nelson, {Christopher P} and Christopher Newton-Cheh and Sekar Kathiresan and Reilly, {Muredach P} and Assimes, {Themistocles L} and Eric Boerwinkle and Hall, {Alistair S} and Christian Hengstenberg and Reijo Laaksonen and Ruth McPherson and Unnur Thorsteinsdottir and Andreas Ziegler and Annette Peters and Thompson, {John R} and K{\"o}nig, {Inke R} and Jeanette Erdmann and Samani, {Nilesh J} and Vasan, {Ramachandran S} and Heribert Schunkert and {CARDIoGRAM Consortium} and Tanja Zeller and Stefan Blankenberg",
year = "2013",
month = may,
doi = "10.1161/HYPERTENSIONAHA.111.00275",
language = "English",
volume = "61",
pages = "995--1001",
journal = "HYPERTENSION",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Genetic predisposition to higher blood pressure increases coronary artery disease risk

AU - Lieb, Wolfgang

AU - Jansen, Henning

AU - Loley, Christina

AU - Pencina, Michael J

AU - Nelson, Christopher P

AU - Newton-Cheh, Christopher

AU - Kathiresan, Sekar

AU - Reilly, Muredach P

AU - Assimes, Themistocles L

AU - Boerwinkle, Eric

AU - Hall, Alistair S

AU - Hengstenberg, Christian

AU - Laaksonen, Reijo

AU - McPherson, Ruth

AU - Thorsteinsdottir, Unnur

AU - Ziegler, Andreas

AU - Peters, Annette

AU - Thompson, John R

AU - König, Inke R

AU - Erdmann, Jeanette

AU - Samani, Nilesh J

AU - Vasan, Ramachandran S

AU - Schunkert, Heribert

AU - CARDIoGRAM Consortium

AU - Zeller, Tanja

AU - Blankenberg, Stefan

PY - 2013/5

Y1 - 2013/5

N2 - Hypertension is a risk factor for coronary artery disease. Recent genome-wide association studies have identified 30 genetic variants associated with higher blood pressure at genome-wide significance (P<5 × 10(-8)). If elevated blood pressure is a causative factor for coronary artery disease, these variants should also increase coronary artery disease risk. Analyzing genome-wide association data from 22 233 coronary artery disease cases and 64 762 controls, we observed in the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) consortium that 88% of these blood pressure-associated polymorphisms were likewise positively associated with coronary artery disease, that is, they had an odds ratio >1 for coronary artery disease, a proportion much higher than expected by chance (P=4 × 10(-5)). The average relative coronary artery disease risk increase per each of the multiple blood pressure-raising alleles observed in the consortium was 3.0% for systolic blood pressure-associated polymorphisms (95% confidence interval, 1.8%-4.3%) and 2.9% for diastolic blood pressure-associated polymorphisms (95% confidence interval, 1.7%-4.1%). In substudies, individuals carrying most systolic blood pressure- and diastolic blood pressure-related risk alleles (top quintile of a genetic risk score distribution) had 70% (95% confidence interval, 50%-94%) and 59% (95% confidence interval, 40%-81%) higher odds of having coronary artery disease, respectively, as compared with individuals in the bottom quintile. In conclusion, most blood pressure-associated polymorphisms also confer an increased risk for coronary artery disease. These findings are consistent with a causal relationship of increasing blood pressure to coronary artery disease. Genetic variants primarily affecting blood pressure contribute to the genetic basis of coronary artery disease.

AB - Hypertension is a risk factor for coronary artery disease. Recent genome-wide association studies have identified 30 genetic variants associated with higher blood pressure at genome-wide significance (P<5 × 10(-8)). If elevated blood pressure is a causative factor for coronary artery disease, these variants should also increase coronary artery disease risk. Analyzing genome-wide association data from 22 233 coronary artery disease cases and 64 762 controls, we observed in the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) consortium that 88% of these blood pressure-associated polymorphisms were likewise positively associated with coronary artery disease, that is, they had an odds ratio >1 for coronary artery disease, a proportion much higher than expected by chance (P=4 × 10(-5)). The average relative coronary artery disease risk increase per each of the multiple blood pressure-raising alleles observed in the consortium was 3.0% for systolic blood pressure-associated polymorphisms (95% confidence interval, 1.8%-4.3%) and 2.9% for diastolic blood pressure-associated polymorphisms (95% confidence interval, 1.7%-4.1%). In substudies, individuals carrying most systolic blood pressure- and diastolic blood pressure-related risk alleles (top quintile of a genetic risk score distribution) had 70% (95% confidence interval, 50%-94%) and 59% (95% confidence interval, 40%-81%) higher odds of having coronary artery disease, respectively, as compared with individuals in the bottom quintile. In conclusion, most blood pressure-associated polymorphisms also confer an increased risk for coronary artery disease. These findings are consistent with a causal relationship of increasing blood pressure to coronary artery disease. Genetic variants primarily affecting blood pressure contribute to the genetic basis of coronary artery disease.

KW - Adult

KW - Aged

KW - Alleles

KW - Blood Pressure/genetics

KW - Case-Control Studies

KW - Coronary Artery Disease/epidemiology

KW - Female

KW - Genetic Predisposition to Disease/genetics

KW - Genome-Wide Association Study

KW - Humans

KW - Hypertension/genetics

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide/genetics

KW - Risk Factors

U2 - 10.1161/HYPERTENSIONAHA.111.00275

DO - 10.1161/HYPERTENSIONAHA.111.00275

M3 - SCORING: Journal article

C2 - 23478099

VL - 61

SP - 995

EP - 1001

JO - HYPERTENSION

JF - HYPERTENSION

SN - 0194-911X

IS - 5

ER -