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Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

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Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. / Zembrzycki, Andreas; Stocker, Adam M; Leingärtner, Axel; Sahara, Setsuko; Chou, Shen-Ju; Kalatsky, Valery; May, Scott R; Stryker, Michael P; O'Leary, Dennis D M.

In: ELIFE, Vol. 4, 24.12.2015.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zembrzycki, A, Stocker, AM, Leingärtner, A, Sahara, S, Chou, S-J, Kalatsky, V, May, SR, Stryker, MP & O'Leary, DDM 2015, 'Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas', ELIFE, vol. 4. https://doi.org/10.7554/eLife.11416

APA

Zembrzycki, A., Stocker, A. M., Leingärtner, A., Sahara, S., Chou, S-J., Kalatsky, V., May, S. R., Stryker, M. P., & O'Leary, D. D. M. (2015). Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. ELIFE, 4. https://doi.org/10.7554/eLife.11416

Vancouver

Zembrzycki A, Stocker AM, Leingärtner A, Sahara S, Chou S-J, Kalatsky V et al. Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. ELIFE. 2015 Dec 24;4. https://doi.org/10.7554/eLife.11416

Bibtex

@article{5b669a7b5dfc4f34bd4520e1ea060ab5,
title = "Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas",
abstract = "In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify primary areas, but mechanisms influencing higher order area properties are unknown. By exploiting gain-of and loss-of function mouse models of the transcription factor Emx2, we have generated bi-directional changes in primary visual cortex size in vivo and have used it as a model to show a novel and prominent function for genetic mechanisms regulating primary visual area size and also proportionally dictating the sizes of surrounding higher order visual areas. This finding redefines the role for intrinsic genetic mechanisms to concomitantly specify and scale primary and related higher order sensory areas in a linear fashion.",
author = "Andreas Zembrzycki and Stocker, {Adam M} and Axel Leing{\"a}rtner and Setsuko Sahara and Shen-Ju Chou and Valery Kalatsky and May, {Scott R} and Stryker, {Michael P} and O'Leary, {Dennis D M}",
year = "2015",
month = dec,
day = "24",
doi = "10.7554/eLife.11416",
language = "English",
volume = "4",
journal = "ELIFE",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS

TY - JOUR

T1 - Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

AU - Zembrzycki, Andreas

AU - Stocker, Adam M

AU - Leingärtner, Axel

AU - Sahara, Setsuko

AU - Chou, Shen-Ju

AU - Kalatsky, Valery

AU - May, Scott R

AU - Stryker, Michael P

AU - O'Leary, Dennis D M

PY - 2015/12/24

Y1 - 2015/12/24

N2 - In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify primary areas, but mechanisms influencing higher order area properties are unknown. By exploiting gain-of and loss-of function mouse models of the transcription factor Emx2, we have generated bi-directional changes in primary visual cortex size in vivo and have used it as a model to show a novel and prominent function for genetic mechanisms regulating primary visual area size and also proportionally dictating the sizes of surrounding higher order visual areas. This finding redefines the role for intrinsic genetic mechanisms to concomitantly specify and scale primary and related higher order sensory areas in a linear fashion.

AB - In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify primary areas, but mechanisms influencing higher order area properties are unknown. By exploiting gain-of and loss-of function mouse models of the transcription factor Emx2, we have generated bi-directional changes in primary visual cortex size in vivo and have used it as a model to show a novel and prominent function for genetic mechanisms regulating primary visual area size and also proportionally dictating the sizes of surrounding higher order visual areas. This finding redefines the role for intrinsic genetic mechanisms to concomitantly specify and scale primary and related higher order sensory areas in a linear fashion.

U2 - 10.7554/eLife.11416

DO - 10.7554/eLife.11416

M3 - SCORING: Journal article

C2 - 26705332

VL - 4

JO - ELIFE

JF - ELIFE

SN - 2050-084X

ER -