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Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease

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Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease. / Morgen, Katrin; Ramirez, Alfredo; Frölich, Lutz; Tost, Heike; Plichta, Michael M; Kölsch, Heike; Rakebrandt, Fabian; Rienhoff, Otto; Jessen, Frank; Peters, Oliver; Jahn, Holger; Luckhaus, Christian; Hüll, Michael; Gertz, Hermann-Josef; Schröder, Johannes; Hampel, Harald; Teipel, Stefan J; Pantel, Johannes; Heuser, Isabella; Wiltfang, Jens; Rüther, Eckart; Kornhuber, Johannes; Maier, Wolfgang; Meyer-Lindenberg, Andreas.

In: ALZHEIMERS DEMENT, Vol. 10, No. 5 Suppl, 01.10.2014, p. S269-76.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Morgen, K, Ramirez, A, Frölich, L, Tost, H, Plichta, MM, Kölsch, H, Rakebrandt, F, Rienhoff, O, Jessen, F, Peters, O, Jahn, H, Luckhaus, C, Hüll, M, Gertz, H-J, Schröder, J, Hampel, H, Teipel, SJ, Pantel, J, Heuser, I, Wiltfang, J, Rüther, E, Kornhuber, J, Maier, W & Meyer-Lindenberg, A 2014, 'Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease', ALZHEIMERS DEMENT, vol. 10, no. 5 Suppl, pp. S269-76. https://doi.org/10.1016/j.jalz.2013.11.001

APA

Morgen, K., Ramirez, A., Frölich, L., Tost, H., Plichta, M. M., Kölsch, H., Rakebrandt, F., Rienhoff, O., Jessen, F., Peters, O., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H-J., Schröder, J., Hampel, H., Teipel, S. J., Pantel, J., Heuser, I., ... Meyer-Lindenberg, A. (2014). Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease. ALZHEIMERS DEMENT, 10(5 Suppl), S269-76. https://doi.org/10.1016/j.jalz.2013.11.001

Vancouver

Morgen K, Ramirez A, Frölich L, Tost H, Plichta MM, Kölsch H et al. Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease. ALZHEIMERS DEMENT. 2014 Oct 1;10(5 Suppl):S269-76. https://doi.org/10.1016/j.jalz.2013.11.001

Bibtex

@article{b73222d8e5ae4166b4cd6e1792997f9b,
title = "Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease",
abstract = "BACKGROUND: Evidence has emerged indicating that the ε4 allele of APOE and PICALM interact in conferring risk of Alzheimer's disease (AD). The biologic basis of this interaction is unclear, but it is likely to have phenotypic relevance and contribute to the structural and clinical heterogeneity of AD.METHODS: The aim of this study was to investigate interaction effects of the APOE ε4 allele and the alleles at the single-nucleotide polymorphism rs3851179 located in the PICALM locus. We analyzed brain volumes and cognitive phenotypes of 165 patients with early AD dementia.RESULTS: There was a synergistic adverse effect of homozygosity for the PICALM risk allele G in rs3851179 and APOE ε4 on volume in prefrontal and performance on the Trail Making Test A, which is sensitive to processing speed and working memory function.CONCLUSIONS: The data suggest a neural mechanism for APOE-PICALM interactions in patients with manifest AD and indicate that the PICALM genotype modulates both brain atrophy and cognitive performance in APOE ε4 carriers.",
author = "Katrin Morgen and Alfredo Ramirez and Lutz Fr{\"o}lich and Heike Tost and Plichta, {Michael M} and Heike K{\"o}lsch and Fabian Rakebrandt and Otto Rienhoff and Frank Jessen and Oliver Peters and Holger Jahn and Christian Luckhaus and Michael H{\"u}ll and Hermann-Josef Gertz and Johannes Schr{\"o}der and Harald Hampel and Teipel, {Stefan J} and Johannes Pantel and Isabella Heuser and Jens Wiltfang and Eckart R{\"u}ther and Johannes Kornhuber and Wolfgang Maier and Andreas Meyer-Lindenberg",
note = "Copyright {\textcopyright} 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.",
year = "2014",
month = oct,
day = "1",
doi = "10.1016/j.jalz.2013.11.001",
language = "English",
volume = "10",
pages = "S269--76",
journal = "ALZHEIMERS DEMENT",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "5 Suppl",

}

RIS

TY - JOUR

T1 - Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease

AU - Morgen, Katrin

AU - Ramirez, Alfredo

AU - Frölich, Lutz

AU - Tost, Heike

AU - Plichta, Michael M

AU - Kölsch, Heike

AU - Rakebrandt, Fabian

AU - Rienhoff, Otto

AU - Jessen, Frank

AU - Peters, Oliver

AU - Jahn, Holger

AU - Luckhaus, Christian

AU - Hüll, Michael

AU - Gertz, Hermann-Josef

AU - Schröder, Johannes

AU - Hampel, Harald

AU - Teipel, Stefan J

AU - Pantel, Johannes

AU - Heuser, Isabella

AU - Wiltfang, Jens

AU - Rüther, Eckart

AU - Kornhuber, Johannes

AU - Maier, Wolfgang

AU - Meyer-Lindenberg, Andreas

N1 - Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - BACKGROUND: Evidence has emerged indicating that the ε4 allele of APOE and PICALM interact in conferring risk of Alzheimer's disease (AD). The biologic basis of this interaction is unclear, but it is likely to have phenotypic relevance and contribute to the structural and clinical heterogeneity of AD.METHODS: The aim of this study was to investigate interaction effects of the APOE ε4 allele and the alleles at the single-nucleotide polymorphism rs3851179 located in the PICALM locus. We analyzed brain volumes and cognitive phenotypes of 165 patients with early AD dementia.RESULTS: There was a synergistic adverse effect of homozygosity for the PICALM risk allele G in rs3851179 and APOE ε4 on volume in prefrontal and performance on the Trail Making Test A, which is sensitive to processing speed and working memory function.CONCLUSIONS: The data suggest a neural mechanism for APOE-PICALM interactions in patients with manifest AD and indicate that the PICALM genotype modulates both brain atrophy and cognitive performance in APOE ε4 carriers.

AB - BACKGROUND: Evidence has emerged indicating that the ε4 allele of APOE and PICALM interact in conferring risk of Alzheimer's disease (AD). The biologic basis of this interaction is unclear, but it is likely to have phenotypic relevance and contribute to the structural and clinical heterogeneity of AD.METHODS: The aim of this study was to investigate interaction effects of the APOE ε4 allele and the alleles at the single-nucleotide polymorphism rs3851179 located in the PICALM locus. We analyzed brain volumes and cognitive phenotypes of 165 patients with early AD dementia.RESULTS: There was a synergistic adverse effect of homozygosity for the PICALM risk allele G in rs3851179 and APOE ε4 on volume in prefrontal and performance on the Trail Making Test A, which is sensitive to processing speed and working memory function.CONCLUSIONS: The data suggest a neural mechanism for APOE-PICALM interactions in patients with manifest AD and indicate that the PICALM genotype modulates both brain atrophy and cognitive performance in APOE ε4 carriers.

U2 - 10.1016/j.jalz.2013.11.001

DO - 10.1016/j.jalz.2013.11.001

M3 - SCORING: Journal article

C2 - 24613704

VL - 10

SP - S269-76

JO - ALZHEIMERS DEMENT

JF - ALZHEIMERS DEMENT

SN - 1552-5260

IS - 5 Suppl

ER -