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Genetic gating of human fear learning and extinction

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Genetic gating of human fear learning and extinction : possible implications for gene-environment interaction in anxiety disorder. / Lonsdorf, Tina B; Weike, Almut I; Nikamo, Pernilla; Schalling, Martin; Hamm, Alfons O; Ohman, Arne.

In: PSYCHOL SCI, Vol. 20, No. 2, 01.02.2009, p. 198-206.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lonsdorf, TB, Weike, AI, Nikamo, P, Schalling, M, Hamm, AO & Ohman, A 2009, 'Genetic gating of human fear learning and extinction: possible implications for gene-environment interaction in anxiety disorder', PSYCHOL SCI, vol. 20, no. 2, pp. 198-206. https://doi.org/10.1111/j.1467-9280.2009.02280.x

APA

Lonsdorf, T. B., Weike, A. I., Nikamo, P., Schalling, M., Hamm, A. O., & Ohman, A. (2009). Genetic gating of human fear learning and extinction: possible implications for gene-environment interaction in anxiety disorder. PSYCHOL SCI, 20(2), 198-206. https://doi.org/10.1111/j.1467-9280.2009.02280.x

Vancouver

Lonsdorf TB, Weike AI, Nikamo P, Schalling M, Hamm AO, Ohman A. Genetic gating of human fear learning and extinction: possible implications for gene-environment interaction in anxiety disorder. PSYCHOL SCI. 2009 Feb 1;20(2):198-206. https://doi.org/10.1111/j.1467-9280.2009.02280.x

Bibtex

@article{1f82878c3f7944658f1e7cb1b6db2dbc,
title = "Genetic gating of human fear learning and extinction: possible implications for gene-environment interaction in anxiety disorder",
abstract = "Pavlovian fear conditioning is a widely used model of the acquisition and extinction of fear. Neural findings suggest that the amygdala is the core structure for fear acquisition, whereas prefrontal cortical areas are given pivotal roles in fear extinction. Forty-eight volunteers participated in a fear-conditioning experiment, which used fear potentiation of the startle reflex as the primary measure to investigate the effect of two genetic polymorphisms (5-HTTLPR and COMTval158met) on conditioning and extinction of fear. The 5-HTTLPR polymorphism, located in the serotonin transporter gene, is associated with amygdala reactivity and neuroticism, whereas the COMTval158met polymorphism, which is located in the gene coding for catechol-O-methyltransferase (COMT), a dopamine-degrading enzyme, affects prefrontal executive functions. Our results show that only carriers of the 5-HTTLPR s allele exhibited conditioned startle potentiation, whereas carriers of the COMT met/met genotype failed to extinguish conditioned fear. These results may have interesting implications for understanding gene-environment interactions in the development and treatment of anxiety disorders.",
keywords = "Adult, Alleles, Anxiety Disorders, Catechol O-Methyltransferase, Conditioning (Psychology), Environment, Extinction, Psychological, Fear, Female, Genotype, Humans, Learning, Male, Prefrontal Cortex, Serotonin Plasma Membrane Transport Proteins",
author = "Lonsdorf, {Tina B} and Weike, {Almut I} and Pernilla Nikamo and Martin Schalling and Hamm, {Alfons O} and Arne Ohman",
year = "2009",
month = feb,
day = "1",
doi = "10.1111/j.1467-9280.2009.02280.x",
language = "English",
volume = "20",
pages = "198--206",
journal = "PSYCHOL SCI",
issn = "0956-7976",
publisher = "SAGE Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Genetic gating of human fear learning and extinction

T2 - possible implications for gene-environment interaction in anxiety disorder

AU - Lonsdorf, Tina B

AU - Weike, Almut I

AU - Nikamo, Pernilla

AU - Schalling, Martin

AU - Hamm, Alfons O

AU - Ohman, Arne

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Pavlovian fear conditioning is a widely used model of the acquisition and extinction of fear. Neural findings suggest that the amygdala is the core structure for fear acquisition, whereas prefrontal cortical areas are given pivotal roles in fear extinction. Forty-eight volunteers participated in a fear-conditioning experiment, which used fear potentiation of the startle reflex as the primary measure to investigate the effect of two genetic polymorphisms (5-HTTLPR and COMTval158met) on conditioning and extinction of fear. The 5-HTTLPR polymorphism, located in the serotonin transporter gene, is associated with amygdala reactivity and neuroticism, whereas the COMTval158met polymorphism, which is located in the gene coding for catechol-O-methyltransferase (COMT), a dopamine-degrading enzyme, affects prefrontal executive functions. Our results show that only carriers of the 5-HTTLPR s allele exhibited conditioned startle potentiation, whereas carriers of the COMT met/met genotype failed to extinguish conditioned fear. These results may have interesting implications for understanding gene-environment interactions in the development and treatment of anxiety disorders.

AB - Pavlovian fear conditioning is a widely used model of the acquisition and extinction of fear. Neural findings suggest that the amygdala is the core structure for fear acquisition, whereas prefrontal cortical areas are given pivotal roles in fear extinction. Forty-eight volunteers participated in a fear-conditioning experiment, which used fear potentiation of the startle reflex as the primary measure to investigate the effect of two genetic polymorphisms (5-HTTLPR and COMTval158met) on conditioning and extinction of fear. The 5-HTTLPR polymorphism, located in the serotonin transporter gene, is associated with amygdala reactivity and neuroticism, whereas the COMTval158met polymorphism, which is located in the gene coding for catechol-O-methyltransferase (COMT), a dopamine-degrading enzyme, affects prefrontal executive functions. Our results show that only carriers of the 5-HTTLPR s allele exhibited conditioned startle potentiation, whereas carriers of the COMT met/met genotype failed to extinguish conditioned fear. These results may have interesting implications for understanding gene-environment interactions in the development and treatment of anxiety disorders.

KW - Adult

KW - Alleles

KW - Anxiety Disorders

KW - Catechol O-Methyltransferase

KW - Conditioning (Psychology)

KW - Environment

KW - Extinction, Psychological

KW - Fear

KW - Female

KW - Genotype

KW - Humans

KW - Learning

KW - Male

KW - Prefrontal Cortex

KW - Serotonin Plasma Membrane Transport Proteins

U2 - 10.1111/j.1467-9280.2009.02280.x

DO - 10.1111/j.1467-9280.2009.02280.x

M3 - SCORING: Journal article

C2 - 19175757

VL - 20

SP - 198

EP - 206

JO - PSYCHOL SCI

JF - PSYCHOL SCI

SN - 0956-7976

IS - 2

ER -