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Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

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Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. / Jones, Lesley; Holmans, Peter A; Hamshere, Marian L; Harold, Denise; Moskvina, Valentina; Ivanov, Dobril; Pocklington, Andrew; Abraham, Richard; Hollingworth, Paul; Sims, Rebecca; Gerrish, Amy; Pahwa, Jaspreet Singh; Jones, Nicola; Stretton, Alexandra; Morgan, Angharad R; Lovestone, Simon; Powell, John; Proitsi, Petroula; Lupton, Michelle K; Brayne, Carol; Rubinsztein, David C; Gill, Michael; Lawlor, Brian; Lynch, Aoibhinn; Morgan, Kevin; Brown, Kristelle S; Passmore, Peter A; Craig, David; McGuinness, Bernadette; Todd, Stephen; Holmes, Clive; Mann, David; Smith, A David; Love, Seth; Kehoe, Patrick G; Mead, Simon; Fox, Nick; Rossor, Martin; Collinge, John; Maier, Wolfgang; Jessen, Frank; Schürmann, Britta; Bussche van den, Hendrik; Heuser, Isabella; Peters, Oliver; Kornhuber, Johannes; Wiltfang, Jens; Dichgans, Martin; Frölich, Lutz; Hampel, Harald; Hüll, Michael; Rujescu, Dan; Goate, Alison M; Kauwe, John S K; Cruchaga, Carlos; Nowotny, Petra; Morris, John C; Mayo, Kevin; Livingston, Gill; Bass, Nicholas J; Gurling, Hugh; McQuillin, Andrew; Gwilliam, Rhian; Deloukas, Panos; Al-Chalabi, Ammar; Shaw, Christopher E; Singleton, Andrew B; Guerreiro, Rita; Mühleisen, Thomas W; Nöthen, Markus M; Moebus, Susanne; Jöckel, Karl-Heinz; Klopp, Norman; Wichmann, H-Erich; Rüther, Eckhard; Carrasquillo, Minerva M; Pankratz, V Shane; Younkin, Steven G; Hardy, John; O'Donovan Michael, C; Owen, Michael J; Williams, Julie.

In: PLOS ONE, Vol. 5, No. 11, 11, 2010, p. 13950.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jones, L, Holmans, PA, Hamshere, ML, Harold, D, Moskvina, V, Ivanov, D, Pocklington, A, Abraham, R, Hollingworth, P, Sims, R, Gerrish, A, Pahwa, JS, Jones, N, Stretton, A, Morgan, AR, Lovestone, S, Powell, J, Proitsi, P, Lupton, MK, Brayne, C, Rubinsztein, DC, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, KS, Passmore, PA, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, AD, Love, S, Kehoe, PG, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Schürmann, B, Bussche van den, H, Heuser, I, Peters, O, Kornhuber, J, Wiltfang, J, Dichgans, M, Frölich, L, Hampel, H, Hüll, M, Rujescu, D, Goate, AM, Kauwe, JSK, Cruchaga, C, Nowotny, P, Morris, JC, Mayo, K, Livingston, G, Bass, NJ, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, CE, Singleton, AB, Guerreiro, R, Mühleisen, TW, Nöthen, MM, Moebus, S, Jöckel, K-H, Klopp, N, Wichmann, H-E, Rüther, E, Carrasquillo, MM, Pankratz, VS, Younkin, SG, Hardy, J, O'Donovan Michael, C, Owen, MJ & Williams, J 2010, 'Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.', PLOS ONE, vol. 5, no. 11, 11, pp. 13950. https://doi.org/10.1371/journal.pone.0013950

APA

Jones, L., Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Pahwa, J. S., Jones, N., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., ... Williams, J. (2010). Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLOS ONE, 5(11), 13950. [11]. https://doi.org/10.1371/journal.pone.0013950

Vancouver

Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLOS ONE. 2010;5(11):13950. 11. https://doi.org/10.1371/journal.pone.0013950

Bibtex

@article{40237365463848fea4aca312fb73fd1e,
title = "Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.",
abstract = "Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes.",
author = "Lesley Jones and Holmans, {Peter A} and Hamshere, {Marian L} and Denise Harold and Valentina Moskvina and Dobril Ivanov and Andrew Pocklington and Richard Abraham and Paul Hollingworth and Rebecca Sims and Amy Gerrish and Pahwa, {Jaspreet Singh} and Nicola Jones and Alexandra Stretton and Morgan, {Angharad R} and Simon Lovestone and John Powell and Petroula Proitsi and Lupton, {Michelle K} and Carol Brayne and Rubinsztein, {David C} and Michael Gill and Brian Lawlor and Aoibhinn Lynch and Kevin Morgan and Brown, {Kristelle S} and Passmore, {Peter A} and David Craig and Bernadette McGuinness and Stephen Todd and Clive Holmes and David Mann and Smith, {A David} and Seth Love and Kehoe, {Patrick G} and Simon Mead and Nick Fox and Martin Rossor and John Collinge and Wolfgang Maier and Frank Jessen and Britta Sch{\"u}rmann and {Bussche van den}, Hendrik and Isabella Heuser and Oliver Peters and Johannes Kornhuber and Jens Wiltfang and Martin Dichgans and Lutz Fr{\"o}lich and Harald Hampel and Michael H{\"u}ll and Dan Rujescu and Goate, {Alison M} and Kauwe, {John S K} and Carlos Cruchaga and Petra Nowotny and Morris, {John C} and Kevin Mayo and Gill Livingston and Bass, {Nicholas J} and Hugh Gurling and Andrew McQuillin and Rhian Gwilliam and Panos Deloukas and Ammar Al-Chalabi and Shaw, {Christopher E} and Singleton, {Andrew B} and Rita Guerreiro and M{\"u}hleisen, {Thomas W} and N{\"o}then, {Markus M} and Susanne Moebus and Karl-Heinz J{\"o}ckel and Norman Klopp and H-Erich Wichmann and Eckhard R{\"u}ther and Carrasquillo, {Minerva M} and Pankratz, {V Shane} and Younkin, {Steven G} and John Hardy and {O'Donovan Michael}, C and Owen, {Michael J} and Julie Williams",
year = "2010",
doi = "10.1371/journal.pone.0013950",
language = "Deutsch",
volume = "5",
pages = "13950",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

AU - Jones, Lesley

AU - Holmans, Peter A

AU - Hamshere, Marian L

AU - Harold, Denise

AU - Moskvina, Valentina

AU - Ivanov, Dobril

AU - Pocklington, Andrew

AU - Abraham, Richard

AU - Hollingworth, Paul

AU - Sims, Rebecca

AU - Gerrish, Amy

AU - Pahwa, Jaspreet Singh

AU - Jones, Nicola

AU - Stretton, Alexandra

AU - Morgan, Angharad R

AU - Lovestone, Simon

AU - Powell, John

AU - Proitsi, Petroula

AU - Lupton, Michelle K

AU - Brayne, Carol

AU - Rubinsztein, David C

AU - Gill, Michael

AU - Lawlor, Brian

AU - Lynch, Aoibhinn

AU - Morgan, Kevin

AU - Brown, Kristelle S

AU - Passmore, Peter A

AU - Craig, David

AU - McGuinness, Bernadette

AU - Todd, Stephen

AU - Holmes, Clive

AU - Mann, David

AU - Smith, A David

AU - Love, Seth

AU - Kehoe, Patrick G

AU - Mead, Simon

AU - Fox, Nick

AU - Rossor, Martin

AU - Collinge, John

AU - Maier, Wolfgang

AU - Jessen, Frank

AU - Schürmann, Britta

AU - Bussche van den, Hendrik

AU - Heuser, Isabella

AU - Peters, Oliver

AU - Kornhuber, Johannes

AU - Wiltfang, Jens

AU - Dichgans, Martin

AU - Frölich, Lutz

AU - Hampel, Harald

AU - Hüll, Michael

AU - Rujescu, Dan

AU - Goate, Alison M

AU - Kauwe, John S K

AU - Cruchaga, Carlos

AU - Nowotny, Petra

AU - Morris, John C

AU - Mayo, Kevin

AU - Livingston, Gill

AU - Bass, Nicholas J

AU - Gurling, Hugh

AU - McQuillin, Andrew

AU - Gwilliam, Rhian

AU - Deloukas, Panos

AU - Al-Chalabi, Ammar

AU - Shaw, Christopher E

AU - Singleton, Andrew B

AU - Guerreiro, Rita

AU - Mühleisen, Thomas W

AU - Nöthen, Markus M

AU - Moebus, Susanne

AU - Jöckel, Karl-Heinz

AU - Klopp, Norman

AU - Wichmann, H-Erich

AU - Rüther, Eckhard

AU - Carrasquillo, Minerva M

AU - Pankratz, V Shane

AU - Younkin, Steven G

AU - Hardy, John

AU - O'Donovan Michael, C

AU - Owen, Michael J

AU - Williams, Julie

PY - 2010

Y1 - 2010

N2 - Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes.

AB - Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes.

U2 - 10.1371/journal.pone.0013950

DO - 10.1371/journal.pone.0013950

M3 - SCORING: Zeitschriftenaufsatz

VL - 5

SP - 13950

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 11

M1 - 11

ER -