Research ExplorerPublicationsGenetic and environmental determinants of dimethylarginines ...

Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes

Standard

Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes. / Anderssohn, Maike; McLachlan, Stela; Lüneburg, Nicole; Robertson, Christine; Schwedhelm, Edzard; Williamson, Rachel M; Strachan, Mark W J; Ajjan, Ramzi; Grant, Peter J; Böger, Rainer H; Price, Jackie F.

In: DIABETES CARE, Vol. 37, No. 3, 01.03.2014, p. 846-854.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Anderssohn, M, McLachlan, S, Lüneburg, N, Robertson, C, Schwedhelm, E, Williamson, RM, Strachan, MWJ, Ajjan, R, Grant, PJ, Böger, RH & Price, JF 2014, 'Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes', DIABETES CARE, vol. 37, no. 3, pp. 846-854. https://doi.org/10.2337/dc13-0546

APA

Anderssohn, M., McLachlan, S., Lüneburg, N., Robertson, C., Schwedhelm, E., Williamson, R. M., Strachan, M. W. J., Ajjan, R., Grant, P. J., Böger, R. H., & Price, J. F. (2014). Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes. DIABETES CARE, 37(3), 846-854. https://doi.org/10.2337/dc13-0546

Vancouver

Anderssohn M, McLachlan S, Lüneburg N, Robertson C, Schwedhelm E, Williamson RM et al. Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes. DIABETES CARE. 2014 Mar 1;37(3):846-854. https://doi.org/10.2337/dc13-0546

Bibtex

@article{c2638b0ff4c64aa2bfc1e5f92e7dd8f2,
title = "Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes",
abstract = "OBJECTIVE: To investigate determinants of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), including single nucleotide polymorphisms (SNPs), in the DDAH1, DDAH2, and AGXT2 genes and their associations with prevalent and incident cardiovascular disease (CVD) in older adults with type 2 diabetes mellitus.RESEARCH DESIGN AND METHODS: Prevalent CVD was assessed in men and women aged 60-75 years with type 2 diabetes as part of the Edinburgh Type 2 Diabetes Study (ET2DS), and the participants were prospectively followed up for 4 years for incident CVD. Dimethylarginines were measured in 783 of these subjects, and genotyping for tag SNPs in the DDAH1, DDAH2, and AGXT2 genes was performed in 935 subjects.RESULTS: Plasma ADMA levels were significantly associated with SNPs in DDAH1 (top SNP rs1554597; P = 9.0E-09), while SDMA levels were associated with SNPs in AGXT2 (top SNP rs28305; P = 1.3E-04). Significant, independent determinants of plasma ADMA were sex, L-arginine, creatinine, fasting glucose, and rs1554597 (all P < 0.05; combined R(2) = 0.213). Determinants of SDMA were age, sex, creatinine, L-arginine, diabetes duration, prevalent CVD, and rs28305 (all P < 0.05; combined R(2) = 0.425). Neither dimethylarginine was associated with incident CVD. None of the investigated SNPs were associated with overall CVD, although subgroup analysis revealed a significant association of AGXT2 rs28305 with intermittent claudication.CONCLUSIONS: Our study in a well-characterized population with type 2 diabetes does not support reported associations or causal relationship between ADMA and features of diabetes or CVD.",
author = "Maike Anderssohn and Stela McLachlan and Nicole L{\"u}neburg and Christine Robertson and Edzard Schwedhelm and Williamson, {Rachel M} and Strachan, {Mark W J} and Ramzi Ajjan and Grant, {Peter J} and B{\"o}ger, {Rainer H} and Price, {Jackie F}",
year = "2014",
month = mar,
day = "1",
doi = "10.2337/dc13-0546",
language = "English",
volume = "37",
pages = "846--854",
journal = "DIABETES CARE",
issn = "0149-5992",
publisher = "American Diabetes Association Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes

AU - Anderssohn, Maike

AU - McLachlan, Stela

AU - Lüneburg, Nicole

AU - Robertson, Christine

AU - Schwedhelm, Edzard

AU - Williamson, Rachel M

AU - Strachan, Mark W J

AU - Ajjan, Ramzi

AU - Grant, Peter J

AU - Böger, Rainer H

AU - Price, Jackie F

PY - 2014/3/1

Y1 - 2014/3/1

N2 - OBJECTIVE: To investigate determinants of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), including single nucleotide polymorphisms (SNPs), in the DDAH1, DDAH2, and AGXT2 genes and their associations with prevalent and incident cardiovascular disease (CVD) in older adults with type 2 diabetes mellitus.RESEARCH DESIGN AND METHODS: Prevalent CVD was assessed in men and women aged 60-75 years with type 2 diabetes as part of the Edinburgh Type 2 Diabetes Study (ET2DS), and the participants were prospectively followed up for 4 years for incident CVD. Dimethylarginines were measured in 783 of these subjects, and genotyping for tag SNPs in the DDAH1, DDAH2, and AGXT2 genes was performed in 935 subjects.RESULTS: Plasma ADMA levels were significantly associated with SNPs in DDAH1 (top SNP rs1554597; P = 9.0E-09), while SDMA levels were associated with SNPs in AGXT2 (top SNP rs28305; P = 1.3E-04). Significant, independent determinants of plasma ADMA were sex, L-arginine, creatinine, fasting glucose, and rs1554597 (all P < 0.05; combined R(2) = 0.213). Determinants of SDMA were age, sex, creatinine, L-arginine, diabetes duration, prevalent CVD, and rs28305 (all P < 0.05; combined R(2) = 0.425). Neither dimethylarginine was associated with incident CVD. None of the investigated SNPs were associated with overall CVD, although subgroup analysis revealed a significant association of AGXT2 rs28305 with intermittent claudication.CONCLUSIONS: Our study in a well-characterized population with type 2 diabetes does not support reported associations or causal relationship between ADMA and features of diabetes or CVD.

AB - OBJECTIVE: To investigate determinants of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), including single nucleotide polymorphisms (SNPs), in the DDAH1, DDAH2, and AGXT2 genes and their associations with prevalent and incident cardiovascular disease (CVD) in older adults with type 2 diabetes mellitus.RESEARCH DESIGN AND METHODS: Prevalent CVD was assessed in men and women aged 60-75 years with type 2 diabetes as part of the Edinburgh Type 2 Diabetes Study (ET2DS), and the participants were prospectively followed up for 4 years for incident CVD. Dimethylarginines were measured in 783 of these subjects, and genotyping for tag SNPs in the DDAH1, DDAH2, and AGXT2 genes was performed in 935 subjects.RESULTS: Plasma ADMA levels were significantly associated with SNPs in DDAH1 (top SNP rs1554597; P = 9.0E-09), while SDMA levels were associated with SNPs in AGXT2 (top SNP rs28305; P = 1.3E-04). Significant, independent determinants of plasma ADMA were sex, L-arginine, creatinine, fasting glucose, and rs1554597 (all P < 0.05; combined R(2) = 0.213). Determinants of SDMA were age, sex, creatinine, L-arginine, diabetes duration, prevalent CVD, and rs28305 (all P < 0.05; combined R(2) = 0.425). Neither dimethylarginine was associated with incident CVD. None of the investigated SNPs were associated with overall CVD, although subgroup analysis revealed a significant association of AGXT2 rs28305 with intermittent claudication.CONCLUSIONS: Our study in a well-characterized population with type 2 diabetes does not support reported associations or causal relationship between ADMA and features of diabetes or CVD.

U2 - 10.2337/dc13-0546

DO - 10.2337/dc13-0546

M3 - SCORING: Journal article

C2 - 24186881

VL - 37

SP - 846

EP - 854

JO - DIABETES CARE

JF - DIABETES CARE

SN - 0149-5992

IS - 3

ER -