Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
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Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study. / Springer, Adrian; Schleberger, Ruben; Oyen, Florian; Hoffmann, Boris A; Willems, Stephan; Meyer, Christian; Langer, Florian; Schnabel, Renate B; Kirchhof, Paulus; Schneppenheim, Reinhard; Lemoine, Marc D.
In: CLIN APPL THROMB-HEM, Vol. 27, 30.06.2021, p. 10760296211021171.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
AU - Springer, Adrian
AU - Schleberger, Ruben
AU - Oyen, Florian
AU - Hoffmann, Boris A
AU - Willems, Stephan
AU - Meyer, Christian
AU - Langer, Florian
AU - Schnabel, Renate B
AU - Kirchhof, Paulus
AU - Schneppenheim, Reinhard
AU - Lemoine, Marc D
PY - 2021/6/30
Y1 - 2021/6/30
N2 - Left atrial (LA) thrombus formation is the presumed origin of thromboembolic complications in patients with atrial fibrillation (AF). Beyond clinical risk factors, the factors causing formation of LA thrombi are not well known. In this case-control study, we analyzed clinical characteristics and genetic thrombophilia markers (factor V Leiden (FVL), prothrombin G20210A (FIIV), Tyr2561 variant of von Willebrand factor (VWF-V)) in 42 patients with AF and LA thrombus (LAT) and in 68 control patients with AF without LAT (CTR). Patients with LAT had more clinical conditions predisposing to stroke (mean CHA2DS2-VASc-score 3.4 ± 1.5 vs. 1.9 ± 1.4; P < 0.001), a higher LA volume (96 ± 32 vs. 76 ± 21 ml, P = 0.002) and lower LA appendage emptying velocity (0.21 ± 0.11vs. 0.43 ± 0.19 m/s, P < 0.001). Prevalence of FVL, FIIV and VWF-V mutations was not different, but in the subgroup of patients <65 years (y) there was a tendency for a higher incidence of VWF-V with a prevalence of 27% (LAT <65 y) vs. 7% (CTR <65 y, P = 0.066). These findings warrant further investigation of the VWF-V as a risk factor for LA thrombogenesis in younger patients.
AB - Left atrial (LA) thrombus formation is the presumed origin of thromboembolic complications in patients with atrial fibrillation (AF). Beyond clinical risk factors, the factors causing formation of LA thrombi are not well known. In this case-control study, we analyzed clinical characteristics and genetic thrombophilia markers (factor V Leiden (FVL), prothrombin G20210A (FIIV), Tyr2561 variant of von Willebrand factor (VWF-V)) in 42 patients with AF and LA thrombus (LAT) and in 68 control patients with AF without LAT (CTR). Patients with LAT had more clinical conditions predisposing to stroke (mean CHA2DS2-VASc-score 3.4 ± 1.5 vs. 1.9 ± 1.4; P < 0.001), a higher LA volume (96 ± 32 vs. 76 ± 21 ml, P = 0.002) and lower LA appendage emptying velocity (0.21 ± 0.11vs. 0.43 ± 0.19 m/s, P < 0.001). Prevalence of FVL, FIIV and VWF-V mutations was not different, but in the subgroup of patients <65 years (y) there was a tendency for a higher incidence of VWF-V with a prevalence of 27% (LAT <65 y) vs. 7% (CTR <65 y, P = 0.066). These findings warrant further investigation of the VWF-V as a risk factor for LA thrombogenesis in younger patients.
U2 - 10.1177/10760296211021171
DO - 10.1177/10760296211021171
M3 - SCORING: Journal article
C2 - 34184557
VL - 27
SP - 10760296211021171
JO - CLIN APPL THROMB-HEM
JF - CLIN APPL THROMB-HEM
SN - 1076-0296
ER -
