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Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2

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Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2. / Pastor-Alonso, Oier; Syeda Zahra, Anum; Kaske, Bente; García-Moreno, Fernando; Tetzlaff, Felix; Bockelmann, Enno; Grunwald, Vanessa; Martín-Suárez, Soraya; Riecken, Kristoffer; Witte, Otto Wilhelm; Encinas, Juan Manuel; Urbach, Anja.

In: EMBO J, Vol. 43, No. 3, 02.2024, p. 317-338.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pastor-Alonso, O, Syeda Zahra, A, Kaske, B, García-Moreno, F, Tetzlaff, F, Bockelmann, E, Grunwald, V, Martín-Suárez, S, Riecken, K, Witte, OW, Encinas, JM & Urbach, A 2024, 'Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2', EMBO J, vol. 43, no. 3, pp. 317-338. https://doi.org/10.1038/s44318-023-00011-2

APA

Pastor-Alonso, O., Syeda Zahra, A., Kaske, B., García-Moreno, F., Tetzlaff, F., Bockelmann, E., Grunwald, V., Martín-Suárez, S., Riecken, K., Witte, O. W., Encinas, J. M., & Urbach, A. (2024). Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2. EMBO J, 43(3), 317-338. https://doi.org/10.1038/s44318-023-00011-2

Vancouver

Pastor-Alonso O, Syeda Zahra A, Kaske B, García-Moreno F, Tetzlaff F, Bockelmann E et al. Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2. EMBO J. 2024 Feb;43(3):317-338. https://doi.org/10.1038/s44318-023-00011-2

Bibtex

@article{b04c7dca697749f4a964057493da955f,
title = "Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2",
abstract = "Lifelong hippocampal neurogenesis is maintained by a pool of multipotent adult neural stem cells (aNSCs) residing in the subgranular zone of the dentate gyrus (DG). The mechanisms guiding transition of NSCs from the developmental to the adult state remain unclear. We show here, by using nestin-based reporter mice deficient for cyclin D2, that the aNSC pool is established through cyclin D2-dependent proliferation during the first two weeks of life. The absence of cyclin D2 does not affect normal development of the dentate gyrus until birth but prevents postnatal formation of radial glia-like aNSCs. Furthermore, retroviral fate mapping reveals that aNSCs are born on-site from precursors located in the dentate gyrus shortly after birth. Taken together, our data identify the critical time window and the spatial location of the precursor divisions that generate the persistent population of aNSCs and demonstrate the central role of cyclin D2 in this process.",
author = "Oier Pastor-Alonso and {Syeda Zahra}, Anum and Bente Kaske and Fernando Garc{\'i}a-Moreno and Felix Tetzlaff and Enno Bockelmann and Vanessa Grunwald and Soraya Mart{\'i}n-Su{\'a}rez and Kristoffer Riecken and Witte, {Otto Wilhelm} and Encinas, {Juan Manuel} and Anja Urbach",
note = "{\textcopyright} 2023. The Author(s).",
year = "2024",
month = feb,
doi = "10.1038/s44318-023-00011-2",
language = "English",
volume = "43",
pages = "317--338",
journal = "EMBO J",
issn = "0261-4189",
publisher = "NATURE PUBLISHING GROUP",
number = "3",

}

RIS

TY - JOUR

T1 - Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2

AU - Pastor-Alonso, Oier

AU - Syeda Zahra, Anum

AU - Kaske, Bente

AU - García-Moreno, Fernando

AU - Tetzlaff, Felix

AU - Bockelmann, Enno

AU - Grunwald, Vanessa

AU - Martín-Suárez, Soraya

AU - Riecken, Kristoffer

AU - Witte, Otto Wilhelm

AU - Encinas, Juan Manuel

AU - Urbach, Anja

N1 - © 2023. The Author(s).

PY - 2024/2

Y1 - 2024/2

N2 - Lifelong hippocampal neurogenesis is maintained by a pool of multipotent adult neural stem cells (aNSCs) residing in the subgranular zone of the dentate gyrus (DG). The mechanisms guiding transition of NSCs from the developmental to the adult state remain unclear. We show here, by using nestin-based reporter mice deficient for cyclin D2, that the aNSC pool is established through cyclin D2-dependent proliferation during the first two weeks of life. The absence of cyclin D2 does not affect normal development of the dentate gyrus until birth but prevents postnatal formation of radial glia-like aNSCs. Furthermore, retroviral fate mapping reveals that aNSCs are born on-site from precursors located in the dentate gyrus shortly after birth. Taken together, our data identify the critical time window and the spatial location of the precursor divisions that generate the persistent population of aNSCs and demonstrate the central role of cyclin D2 in this process.

AB - Lifelong hippocampal neurogenesis is maintained by a pool of multipotent adult neural stem cells (aNSCs) residing in the subgranular zone of the dentate gyrus (DG). The mechanisms guiding transition of NSCs from the developmental to the adult state remain unclear. We show here, by using nestin-based reporter mice deficient for cyclin D2, that the aNSC pool is established through cyclin D2-dependent proliferation during the first two weeks of life. The absence of cyclin D2 does not affect normal development of the dentate gyrus until birth but prevents postnatal formation of radial glia-like aNSCs. Furthermore, retroviral fate mapping reveals that aNSCs are born on-site from precursors located in the dentate gyrus shortly after birth. Taken together, our data identify the critical time window and the spatial location of the precursor divisions that generate the persistent population of aNSCs and demonstrate the central role of cyclin D2 in this process.

U2 - 10.1038/s44318-023-00011-2

DO - 10.1038/s44318-023-00011-2

M3 - SCORING: Journal article

C2 - 38177500

VL - 43

SP - 317

EP - 338

JO - EMBO J

JF - EMBO J

SN - 0261-4189

IS - 3

ER -