Generalization of placebo pain relief

Lea Kampermann; Alexandra Tinnermann; Christian Büchel

doi:10.1097/j.pain.0000000000002166

Generalization of placebo pain relief

Standard

Generalization of placebo pain relief. / Kampermann, Lea; Tinnermann, Alexandra ; Büchel, Christian.

In: PAIN, Vol. 162, No. 6, 01.06.2021, p. 1781-1789.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kampermann, L, Tinnermann, A & Büchel, C 2021, 'Generalization of placebo pain relief', PAIN, vol. 162, no. 6, pp. 1781-1789. https://doi.org/10.1097/j.pain.0000000000002166

APA

Kampermann, L., Tinnermann, A., & Büchel, C. (2021). Generalization of placebo pain relief. PAIN, 162(6), 1781-1789. https://doi.org/10.1097/j.pain.0000000000002166

Vancouver

Kampermann L, Tinnermann A , Büchel C. Generalization of placebo pain relief. PAIN. 2021 Jun 1;162(6):1781-1789. https://doi.org/10.1097/j.pain.0000000000002166

Bibtex

@article{043d0b0f850745af8a2c70b5d923afc0,

title = "Generalization of placebo pain relief",

abstract = "Efficacy of treatment is heavily dependent on experience and expectations. Moreover, humans can generalize from one experience to a perceptually similar but novel situation. We investigated whether and how this applies to pain relief, using ecologically valid tonic pain stimuli treated by surreptitiously lowering the applied temperature. Using different face cues, participants experienced better treatment from one physician than another. Participants were then tested on 6 additional face cues perceptually lying between both faces. Our data from 2 independent samples (N = 18 and N = 39) show a treatment experience effect, ie, for physically identical treatments, the initially superior physician was reported to deliver stronger pain relief. More importantly, the other faces on the perceptual continuum showed a graded effect of pain relief, indicating placebo generalization. Introducing a paradigm feasible to induce placebo pain relief, we show that the generic learning principle of generalization can explain carryover effects between learned and novel treatment situations.",

author = "Lea Kampermann and Alexandra Tinnermann and Christian B{\"u}chel",

note = "Copyright {\textcopyright} 2020 International Association for the Study of Pain.",

year = "2021",

month = jun,

day = "1",

doi = "10.1097/j.pain.0000000000002166",

language = "English",

volume = "162",

pages = "1781--1789",

journal = "PAIN",

issn = "0304-3959",

publisher = "Elsevier",

number = "6",

}

RIS

TY - JOUR

T1 - Generalization of placebo pain relief

AU - Kampermann, Lea

AU - Tinnermann, Alexandra

AU - Büchel, Christian

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Efficacy of treatment is heavily dependent on experience and expectations. Moreover, humans can generalize from one experience to a perceptually similar but novel situation. We investigated whether and how this applies to pain relief, using ecologically valid tonic pain stimuli treated by surreptitiously lowering the applied temperature. Using different face cues, participants experienced better treatment from one physician than another. Participants were then tested on 6 additional face cues perceptually lying between both faces. Our data from 2 independent samples (N = 18 and N = 39) show a treatment experience effect, ie, for physically identical treatments, the initially superior physician was reported to deliver stronger pain relief. More importantly, the other faces on the perceptual continuum showed a graded effect of pain relief, indicating placebo generalization. Introducing a paradigm feasible to induce placebo pain relief, we show that the generic learning principle of generalization can explain carryover effects between learned and novel treatment situations.

AB - Efficacy of treatment is heavily dependent on experience and expectations. Moreover, humans can generalize from one experience to a perceptually similar but novel situation. We investigated whether and how this applies to pain relief, using ecologically valid tonic pain stimuli treated by surreptitiously lowering the applied temperature. Using different face cues, participants experienced better treatment from one physician than another. Participants were then tested on 6 additional face cues perceptually lying between both faces. Our data from 2 independent samples (N = 18 and N = 39) show a treatment experience effect, ie, for physically identical treatments, the initially superior physician was reported to deliver stronger pain relief. More importantly, the other faces on the perceptual continuum showed a graded effect of pain relief, indicating placebo generalization. Introducing a paradigm feasible to induce placebo pain relief, we show that the generic learning principle of generalization can explain carryover effects between learned and novel treatment situations.

U2 - 10.1097/j.pain.0000000000002166

DO - 10.1097/j.pain.0000000000002166

M3 - SCORING: Journal article

C2 - 33394880

VL - 162

SP - 1781

EP - 1789

JO - PAIN

JF - PAIN

SN - 0304-3959

IS - 6

ER -