Gene therapy strategies: can we eradicate HIV?
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Gene therapy strategies: can we eradicate HIV? / van Lunzen, Jan; Fehse, Boris; Hauber, Joachim.
In: CURR HIV-AIDS REP, Vol. 8, No. 2, 2, 2011, p. 78-84.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Gene therapy strategies: can we eradicate HIV?
AU - van Lunzen, Jan
AU - Fehse, Boris
AU - Hauber, Joachim
PY - 2011
Y1 - 2011
N2 - Despite the tremendous advances in antiretroviral combination therapy over the last decade, eradication of HIV from the infected organism is still an elusive goal. Lifelong therapy is associated with potential long-term toxicity, adherence problems, and development of drug resistance. Thus, gene therapy approaches targeting viral eradication are still attractive. Here a number of studies have failed to show a clear clinical benefit yet. Current approaches were mainly limited by a low number of transduced cells and genotoxicity. The use of new vector systems and the right choice of target cells and improved transduction protocols may overcome these obstacles. Recent reports on the use of newly developed transgenes either allowing for an enrichment of transduced cells by an in vivo selection advantage or restoration of a functional immune system which is resistant to HIV infection nourished the hope for continuous progress in this field. Indeed the intriguing finding that HIV seems to be eradicated in an individual case study after stem cell transplantation with a mutant coreceptor (CCR5 delta 32 deletion) underlines the proof of the concept.
AB - Despite the tremendous advances in antiretroviral combination therapy over the last decade, eradication of HIV from the infected organism is still an elusive goal. Lifelong therapy is associated with potential long-term toxicity, adherence problems, and development of drug resistance. Thus, gene therapy approaches targeting viral eradication are still attractive. Here a number of studies have failed to show a clear clinical benefit yet. Current approaches were mainly limited by a low number of transduced cells and genotoxicity. The use of new vector systems and the right choice of target cells and improved transduction protocols may overcome these obstacles. Recent reports on the use of newly developed transgenes either allowing for an enrichment of transduced cells by an in vivo selection advantage or restoration of a functional immune system which is resistant to HIV infection nourished the hope for continuous progress in this field. Indeed the intriguing finding that HIV seems to be eradicated in an individual case study after stem cell transplantation with a mutant coreceptor (CCR5 delta 32 deletion) underlines the proof of the concept.
KW - Humans
KW - Antiretroviral Therapy, Highly Active
KW - Hematopoietic Stem Cell Transplantation
KW - Gene Therapy/methods
KW - Anti-HIV Agents/therapeutic use
KW - HIV Infections/immunology/therapy
KW - Humans
KW - Antiretroviral Therapy, Highly Active
KW - Hematopoietic Stem Cell Transplantation
KW - Gene Therapy/methods
KW - Anti-HIV Agents/therapeutic use
KW - HIV Infections/immunology/therapy
M3 - SCORING: Journal article
VL - 8
SP - 78
EP - 84
JO - CURR HIV-AIDS REP
JF - CURR HIV-AIDS REP
SN - 1548-3568
IS - 2
M1 - 2
ER -
