Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly.
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Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly. / Kölsch, Heike; Wagner, Michael; Bilkei-Gorzó, Andras; Toliat, Mohammad Reza; Pentzek, Michael; Fuchs, Angela; Kaduszkiewicz, Hanna; Bussche van den, Hendrik; Riedel-Heller, Steffi G; Angermeyer, Matthias C; Weyerer, Siegfried; Werle, Jochen; Bickel, Horst; Mösch, Edelgard; Wiese, Birgitt; Daerr, Moritz; Jessen, Frank; Maier, Wolfgang; Dichgans, Martin.
In: J NEURAL TRANSM, Vol. 116, No. 7, 7, 2009, p. 897-903.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly.
AU - Kölsch, Heike
AU - Wagner, Michael
AU - Bilkei-Gorzó, Andras
AU - Toliat, Mohammad Reza
AU - Pentzek, Michael
AU - Fuchs, Angela
AU - Kaduszkiewicz, Hanna
AU - Bussche van den, Hendrik
AU - Riedel-Heller, Steffi G
AU - Angermeyer, Matthias C
AU - Weyerer, Siegfried
AU - Werle, Jochen
AU - Bickel, Horst
AU - Mösch, Edelgard
AU - Wiese, Birgitt
AU - Daerr, Moritz
AU - Jessen, Frank
AU - Maier, Wolfgang
AU - Dichgans, Martin
PY - 2009
Y1 - 2009
N2 - Cognitive functions show large variation in elderly people and are substantially heritable. Animal studies revealed that dynorphins influence cognition and memory, especially in aged animals. Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 +/- 3.39 years; range 75-90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe). We found that carriers of the minor alleles of rs1997794 (P <0.002) and rs910080 (P <0.005) presented with higher episodic memory scores than homozygote carriers of the major allele. Also, a three marker haplotype including these two SNPs and rs2235751 was associated with better episodic memory scores. Verbal fluency scores were non-significantly better in carriers of these respective alleles. Thus, our results suggest a role of PDYN gene variations in determining memory function also in elderly humans.
AB - Cognitive functions show large variation in elderly people and are substantially heritable. Animal studies revealed that dynorphins influence cognition and memory, especially in aged animals. Thus, we tested the effect of four SNPs (rs7272891, rs1997794, rs2235751 and rs910080) and the VNTR promoter polymorphism in the prodynorphin gene (PDYN) on episodic memory and verbal fluency in a large (n = 1619) sample of elderly people (mean age: 80 +/- 3.39 years; range 75-90 years) recruited through the German study on ageing, cognition and dementia in primary care patients (AgeCoDe). We found that carriers of the minor alleles of rs1997794 (P <0.002) and rs910080 (P <0.005) presented with higher episodic memory scores than homozygote carriers of the major allele. Also, a three marker haplotype including these two SNPs and rs2235751 was associated with better episodic memory scores. Verbal fluency scores were non-significantly better in carriers of these respective alleles. Thus, our results suggest a role of PDYN gene variations in determining memory function also in elderly humans.
M3 - SCORING: Zeitschriftenaufsatz
VL - 116
SP - 897
EP - 903
JO - J NEURAL TRANSM
JF - J NEURAL TRANSM
SN - 0300-9564
IS - 7
M1 - 7
ER -
