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Gender-specific Differences in Clinicopathologic Outcomes Following Radical Cystectomy: An International Multi-institutional Study of More Than 8000 Patients

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Gender-specific Differences in Clinicopathologic Outcomes Following Radical Cystectomy: An International Multi-institutional Study of More Than 8000 Patients. / Kluth, Luis A; Rieken, Malte; Xylinas, Evanguelos; Kent, Matthew; Rink, Michael; Rouprêt, Morgan; Sharifi, Nasim; Jamzadeh, Asha; Kassouf, Wassim; Kaushik, Dharam; Boorjian, Stephen A; Roghmann, Florian; Noldus, Joachim; Masson-Lecomte, Alexandra; Vordos, Dimitri; Ikeda, Masaomi; Matsumoto, Kazumasa; Hagiwara, Masayuki; Kikuchi, Eiji; Fradet, Yves; Izawa, Jonathan; Rendon, Ricardo; Fairey, Adrian; Lotan, Yair; Bachmann, Alexander; Zerbib, Marc; Fisch, Margit; Scherr, Douglas S; Vickers, Andrew; Shariat, Shahrokh F.

In: EUR UROL, Vol. 66, No. 5, 2014, p. 913-919.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kluth, LA, Rieken, M, Xylinas, E, Kent, M, Rink, M, Rouprêt, M, Sharifi, N, Jamzadeh, A, Kassouf, W, Kaushik, D, Boorjian, SA, Roghmann, F, Noldus, J, Masson-Lecomte, A, Vordos, D, Ikeda, M, Matsumoto, K, Hagiwara, M, Kikuchi, E, Fradet, Y, Izawa, J, Rendon, R, Fairey, A, Lotan, Y, Bachmann, A, Zerbib, M, Fisch, M, Scherr, DS, Vickers, A & Shariat, SF 2014, 'Gender-specific Differences in Clinicopathologic Outcomes Following Radical Cystectomy: An International Multi-institutional Study of More Than 8000 Patients', EUR UROL, vol. 66, no. 5, pp. 913-919. https://doi.org/10.1016/j.eururo.2013.11.040

APA

Kluth, L. A., Rieken, M., Xylinas, E., Kent, M., Rink, M., Rouprêt, M., Sharifi, N., Jamzadeh, A., Kassouf, W., Kaushik, D., Boorjian, S. A., Roghmann, F., Noldus, J., Masson-Lecomte, A., Vordos, D., Ikeda, M., Matsumoto, K., Hagiwara, M., Kikuchi, E., ... Shariat, S. F. (2014). Gender-specific Differences in Clinicopathologic Outcomes Following Radical Cystectomy: An International Multi-institutional Study of More Than 8000 Patients. EUR UROL, 66(5), 913-919. https://doi.org/10.1016/j.eururo.2013.11.040

Vancouver

Kluth LA, Rieken M, Xylinas E, Kent M, Rink M, Rouprêt M et al. Gender-specific Differences in Clinicopathologic Outcomes Following Radical Cystectomy: An International Multi-institutional Study of More Than 8000 Patients. EUR UROL. 2014;66(5):913-919. https://doi.org/10.1016/j.eururo.2013.11.040

Bibtex

@article{992826df1fd245c2a16f0063ea189a93,
title = "Gender-specific Differences in Clinicopathologic Outcomes Following Radical Cystectomy: An International Multi-institutional Study of More Than 8000 Patients",
abstract = "BACKGROUND: The impact of gender on the staging and prognosis of urothelial carcinoma of the bladder (UCB) is insufficiently understood.OBJECTIVE: To assess gender-specific differences in pathologic factors and survival of UCB patients treated with radical cystectomy (RC).DESIGN, SETTING, AND PARTICIPANTS: Data from 8102 patients treated with RC (6497 men [80%] and 1605 women [20%]) for UCB between 1971 and 2012 were analyzed.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Multivariable competing-risk regression analyses were performed to evaluate the relationship of gender on disease recurrence (DR) and cancer-specific mortality (CSM). We also tested the interaction of gender and tumor stage, nodal status, and lymphovascular invasion (LVI).RESULTS AND LIMITATIONS: Female patients were older at the time of RC (p=0.033) and had higher rates of pathologic stage T3/T4 disease (p<0.001). In univariable, but not in multivariable analysis, female gender was associated with a higher risk of DR (p=0.022 and p=0.11, respectively). Female gender was an independent predictor for CSM (p=0.004). We did not find a significant interaction between gender and stage, nodal metastasis, or LVI (all p values >0.05).CONCLUSIONS: We found female gender to be associated with a higher risk of CSM following RC. However, these findings do not appear to be explained by gender differences in pathologic stage, nodal status, or LVI. This gender disparity may be due to differences in care and/or the biology of UCB.",
author = "Kluth, {Luis A} and Malte Rieken and Evanguelos Xylinas and Matthew Kent and Michael Rink and Morgan Roupr{\^e}t and Nasim Sharifi and Asha Jamzadeh and Wassim Kassouf and Dharam Kaushik and Boorjian, {Stephen A} and Florian Roghmann and Joachim Noldus and Alexandra Masson-Lecomte and Dimitri Vordos and Masaomi Ikeda and Kazumasa Matsumoto and Masayuki Hagiwara and Eiji Kikuchi and Yves Fradet and Jonathan Izawa and Ricardo Rendon and Adrian Fairey and Yair Lotan and Alexander Bachmann and Marc Zerbib and Margit Fisch and Scherr, {Douglas S} and Andrew Vickers and Shariat, {Shahrokh F}",
note = "Copyright {\textcopyright} 2013. Published by Elsevier B.V.",
year = "2014",
doi = "10.1016/j.eururo.2013.11.040",
language = "English",
volume = "66",
pages = "913--919",
journal = "EUR UROL",
issn = "0302-2838",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Gender-specific Differences in Clinicopathologic Outcomes Following Radical Cystectomy: An International Multi-institutional Study of More Than 8000 Patients

AU - Kluth, Luis A

AU - Rieken, Malte

AU - Xylinas, Evanguelos

AU - Kent, Matthew

AU - Rink, Michael

AU - Rouprêt, Morgan

AU - Sharifi, Nasim

AU - Jamzadeh, Asha

AU - Kassouf, Wassim

AU - Kaushik, Dharam

AU - Boorjian, Stephen A

AU - Roghmann, Florian

AU - Noldus, Joachim

AU - Masson-Lecomte, Alexandra

AU - Vordos, Dimitri

AU - Ikeda, Masaomi

AU - Matsumoto, Kazumasa

AU - Hagiwara, Masayuki

AU - Kikuchi, Eiji

AU - Fradet, Yves

AU - Izawa, Jonathan

AU - Rendon, Ricardo

AU - Fairey, Adrian

AU - Lotan, Yair

AU - Bachmann, Alexander

AU - Zerbib, Marc

AU - Fisch, Margit

AU - Scherr, Douglas S

AU - Vickers, Andrew

AU - Shariat, Shahrokh F

N1 - Copyright © 2013. Published by Elsevier B.V.

PY - 2014

Y1 - 2014

N2 - BACKGROUND: The impact of gender on the staging and prognosis of urothelial carcinoma of the bladder (UCB) is insufficiently understood.OBJECTIVE: To assess gender-specific differences in pathologic factors and survival of UCB patients treated with radical cystectomy (RC).DESIGN, SETTING, AND PARTICIPANTS: Data from 8102 patients treated with RC (6497 men [80%] and 1605 women [20%]) for UCB between 1971 and 2012 were analyzed.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Multivariable competing-risk regression analyses were performed to evaluate the relationship of gender on disease recurrence (DR) and cancer-specific mortality (CSM). We also tested the interaction of gender and tumor stage, nodal status, and lymphovascular invasion (LVI).RESULTS AND LIMITATIONS: Female patients were older at the time of RC (p=0.033) and had higher rates of pathologic stage T3/T4 disease (p<0.001). In univariable, but not in multivariable analysis, female gender was associated with a higher risk of DR (p=0.022 and p=0.11, respectively). Female gender was an independent predictor for CSM (p=0.004). We did not find a significant interaction between gender and stage, nodal metastasis, or LVI (all p values >0.05).CONCLUSIONS: We found female gender to be associated with a higher risk of CSM following RC. However, these findings do not appear to be explained by gender differences in pathologic stage, nodal status, or LVI. This gender disparity may be due to differences in care and/or the biology of UCB.

AB - BACKGROUND: The impact of gender on the staging and prognosis of urothelial carcinoma of the bladder (UCB) is insufficiently understood.OBJECTIVE: To assess gender-specific differences in pathologic factors and survival of UCB patients treated with radical cystectomy (RC).DESIGN, SETTING, AND PARTICIPANTS: Data from 8102 patients treated with RC (6497 men [80%] and 1605 women [20%]) for UCB between 1971 and 2012 were analyzed.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Multivariable competing-risk regression analyses were performed to evaluate the relationship of gender on disease recurrence (DR) and cancer-specific mortality (CSM). We also tested the interaction of gender and tumor stage, nodal status, and lymphovascular invasion (LVI).RESULTS AND LIMITATIONS: Female patients were older at the time of RC (p=0.033) and had higher rates of pathologic stage T3/T4 disease (p<0.001). In univariable, but not in multivariable analysis, female gender was associated with a higher risk of DR (p=0.022 and p=0.11, respectively). Female gender was an independent predictor for CSM (p=0.004). We did not find a significant interaction between gender and stage, nodal metastasis, or LVI (all p values >0.05).CONCLUSIONS: We found female gender to be associated with a higher risk of CSM following RC. However, these findings do not appear to be explained by gender differences in pathologic stage, nodal status, or LVI. This gender disparity may be due to differences in care and/or the biology of UCB.

U2 - 10.1016/j.eururo.2013.11.040

DO - 10.1016/j.eururo.2013.11.040

M3 - SCORING: Journal article

C2 - 24331151

VL - 66

SP - 913

EP - 919

JO - EUR UROL

JF - EUR UROL

SN - 0302-2838

IS - 5

ER -