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GDF-15 predicts cardiovascular events in acute chest pain patients

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GDF-15 predicts cardiovascular events in acute chest pain patients. / Tzikas, Stergios; Palapies, Lars; Bakogiannis, Constantinos; Zeller, Tanja; Sinning, Christoph; Baldus, Stephan; Bickel, Christoph; Vassilikos, Vassilios; Lackner, Karl J; Zeiher, Andreas; Münzel, Thomas; Blankenberg, Stefan; Keller, Till.

In: PLOS ONE, Vol. 12, No. 8, e0182314, 2017.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tzikas, S, Palapies, L, Bakogiannis, C, Zeller, T, Sinning, C, Baldus, S, Bickel, C, Vassilikos, V, Lackner, KJ, Zeiher, A, Münzel, T, Blankenberg, S & Keller, T 2017, 'GDF-15 predicts cardiovascular events in acute chest pain patients', PLOS ONE, vol. 12, no. 8, e0182314. https://doi.org/10.1371/journal.pone.0182314

APA

Tzikas, S., Palapies, L., Bakogiannis, C., Zeller, T., Sinning, C., Baldus, S., Bickel, C., Vassilikos, V., Lackner, K. J., Zeiher, A., Münzel, T., Blankenberg, S., & Keller, T. (2017). GDF-15 predicts cardiovascular events in acute chest pain patients. PLOS ONE, 12(8), [e0182314]. https://doi.org/10.1371/journal.pone.0182314

Vancouver

Tzikas S, Palapies L, Bakogiannis C, Zeller T, Sinning C, Baldus S et al. GDF-15 predicts cardiovascular events in acute chest pain patients. PLOS ONE. 2017;12(8). e0182314. https://doi.org/10.1371/journal.pone.0182314

Bibtex

@article{6ff8e92c1ebd47bbb7999806a1a42d09,
title = "GDF-15 predicts cardiovascular events in acute chest pain patients",
abstract = "BACKGROUND: Treatment of patients presenting with possible acute myocardial infarction (AMI) is based on timely diagnosis and proper risk stratification aided by biomarkers. We aimed at evaluating the predictive value of GDF-15 in patients presenting with symptoms suggestive of AMI.METHODS: Consecutive patients presenting with suspected AMI were enrolled in three study centers. Cardiovascular events were assessed during a follow-up period of 6 months with a combined endpoint of death or MI.RESULTS: From the 1818 enrolled patients (m/f = 1208/610), 413 (22.7%) had an acute MI and 63 patients reached the combined endpoint. Patients with MI and patients with adverse outcome had higher GDF-15 levels compared with non-MI patients (967.1pg/mL vs. 692.2 pg/L, p<0.001) and with event-free patients (1660 pg/mL vs. 756.6 pg/L, p<0.001). GDF-15 levels were lower in patients with SYNTAX score ≤ 22 (797.3 pg/mL vs. 947.2 pg/L, p = 0.036). Increased GDF-15 levels on admission were associated with a hazard ratio of 2.1 for death or MI (95%CI: 1.67-2.65, p<0.001) in a model adjusted for age and sex and of 1.57 (1.13-2.19, p = 0.008) adjusted for the GRACE score variables. GDF-15 showed a relevant reclassification with regards to the GRACE score with an overall net reclassification index (NRI) of 12.5% and an integrated discrimination improvement (IDI) of 14.56% (p = 0.006).CONCLUSION: GDF-15 is an independent predictor of future cardiovascular events in patients presenting with suspected MI. GDF-15 levels correlate with the severity of CAD and can identify and risk-stratify patients who need coronary revascularization.",
keywords = "Acute Disease, Aged, Biomarkers/analysis, Chest Pain/etiology, Female, Growth Differentiation Factor 15/analysis, Humans, Kaplan-Meier Estimate, Lipoproteins, HDL/blood, Lipoproteins, LDL/blood, Male, Middle Aged, Myocardial Infarction/diagnosis, Proportional Hazards Models, Risk Factors, Severity of Illness Index, Troponin I/blood",
author = "Stergios Tzikas and Lars Palapies and Constantinos Bakogiannis and Tanja Zeller and Christoph Sinning and Stephan Baldus and Christoph Bickel and Vassilios Vassilikos and Lackner, {Karl J} and Andreas Zeiher and Thomas M{\"u}nzel and Stefan Blankenberg and Till Keller",
year = "2017",
doi = "10.1371/journal.pone.0182314",
language = "English",
volume = "12",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

RIS

TY - JOUR

T1 - GDF-15 predicts cardiovascular events in acute chest pain patients

AU - Tzikas, Stergios

AU - Palapies, Lars

AU - Bakogiannis, Constantinos

AU - Zeller, Tanja

AU - Sinning, Christoph

AU - Baldus, Stephan

AU - Bickel, Christoph

AU - Vassilikos, Vassilios

AU - Lackner, Karl J

AU - Zeiher, Andreas

AU - Münzel, Thomas

AU - Blankenberg, Stefan

AU - Keller, Till

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Treatment of patients presenting with possible acute myocardial infarction (AMI) is based on timely diagnosis and proper risk stratification aided by biomarkers. We aimed at evaluating the predictive value of GDF-15 in patients presenting with symptoms suggestive of AMI.METHODS: Consecutive patients presenting with suspected AMI were enrolled in three study centers. Cardiovascular events were assessed during a follow-up period of 6 months with a combined endpoint of death or MI.RESULTS: From the 1818 enrolled patients (m/f = 1208/610), 413 (22.7%) had an acute MI and 63 patients reached the combined endpoint. Patients with MI and patients with adverse outcome had higher GDF-15 levels compared with non-MI patients (967.1pg/mL vs. 692.2 pg/L, p<0.001) and with event-free patients (1660 pg/mL vs. 756.6 pg/L, p<0.001). GDF-15 levels were lower in patients with SYNTAX score ≤ 22 (797.3 pg/mL vs. 947.2 pg/L, p = 0.036). Increased GDF-15 levels on admission were associated with a hazard ratio of 2.1 for death or MI (95%CI: 1.67-2.65, p<0.001) in a model adjusted for age and sex and of 1.57 (1.13-2.19, p = 0.008) adjusted for the GRACE score variables. GDF-15 showed a relevant reclassification with regards to the GRACE score with an overall net reclassification index (NRI) of 12.5% and an integrated discrimination improvement (IDI) of 14.56% (p = 0.006).CONCLUSION: GDF-15 is an independent predictor of future cardiovascular events in patients presenting with suspected MI. GDF-15 levels correlate with the severity of CAD and can identify and risk-stratify patients who need coronary revascularization.

AB - BACKGROUND: Treatment of patients presenting with possible acute myocardial infarction (AMI) is based on timely diagnosis and proper risk stratification aided by biomarkers. We aimed at evaluating the predictive value of GDF-15 in patients presenting with symptoms suggestive of AMI.METHODS: Consecutive patients presenting with suspected AMI were enrolled in three study centers. Cardiovascular events were assessed during a follow-up period of 6 months with a combined endpoint of death or MI.RESULTS: From the 1818 enrolled patients (m/f = 1208/610), 413 (22.7%) had an acute MI and 63 patients reached the combined endpoint. Patients with MI and patients with adverse outcome had higher GDF-15 levels compared with non-MI patients (967.1pg/mL vs. 692.2 pg/L, p<0.001) and with event-free patients (1660 pg/mL vs. 756.6 pg/L, p<0.001). GDF-15 levels were lower in patients with SYNTAX score ≤ 22 (797.3 pg/mL vs. 947.2 pg/L, p = 0.036). Increased GDF-15 levels on admission were associated with a hazard ratio of 2.1 for death or MI (95%CI: 1.67-2.65, p<0.001) in a model adjusted for age and sex and of 1.57 (1.13-2.19, p = 0.008) adjusted for the GRACE score variables. GDF-15 showed a relevant reclassification with regards to the GRACE score with an overall net reclassification index (NRI) of 12.5% and an integrated discrimination improvement (IDI) of 14.56% (p = 0.006).CONCLUSION: GDF-15 is an independent predictor of future cardiovascular events in patients presenting with suspected MI. GDF-15 levels correlate with the severity of CAD and can identify and risk-stratify patients who need coronary revascularization.

KW - Acute Disease

KW - Aged

KW - Biomarkers/analysis

KW - Chest Pain/etiology

KW - Female

KW - Growth Differentiation Factor 15/analysis

KW - Humans

KW - Kaplan-Meier Estimate

KW - Lipoproteins, HDL/blood

KW - Lipoproteins, LDL/blood

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/diagnosis

KW - Proportional Hazards Models

KW - Risk Factors

KW - Severity of Illness Index

KW - Troponin I/blood

U2 - 10.1371/journal.pone.0182314

DO - 10.1371/journal.pone.0182314

M3 - SCORING: Journal article

C2 - 28771550

VL - 12

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 8

M1 - e0182314

ER -