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Ganglion cell loss after optic nerve crush mediated through AMPA-kainate and NMDA receptors

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Ganglion cell loss after optic nerve crush mediated through AMPA-kainate and NMDA receptors. / Schuettauf, F; Naskar, R; Vorwerk, C K; Zurakowski, D; Dreyer, E B.

In: INVEST OPHTH VIS SCI, Vol. 41, No. 13, 12.2000, p. 4313-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schuettauf, F, Naskar, R, Vorwerk, CK, Zurakowski, D & Dreyer, EB 2000, 'Ganglion cell loss after optic nerve crush mediated through AMPA-kainate and NMDA receptors', INVEST OPHTH VIS SCI, vol. 41, no. 13, pp. 4313-6.

APA

Schuettauf, F., Naskar, R., Vorwerk, C. K., Zurakowski, D., & Dreyer, E. B. (2000). Ganglion cell loss after optic nerve crush mediated through AMPA-kainate and NMDA receptors. INVEST OPHTH VIS SCI, 41(13), 4313-6.

Vancouver

Schuettauf F, Naskar R, Vorwerk CK, Zurakowski D, Dreyer EB. Ganglion cell loss after optic nerve crush mediated through AMPA-kainate and NMDA receptors. INVEST OPHTH VIS SCI. 2000 Dec;41(13):4313-6.

Bibtex

@article{6a6c204dcbce41caa745872e7fa0206c,
title = "Ganglion cell loss after optic nerve crush mediated through AMPA-kainate and NMDA receptors",
abstract = "PURPOSE: Glutamate antagonists can block ganglion cell death due to optic nerve crush. Although most investigators have focused on blockade of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor, we have chosen to evaluate the efficacy of blockade of the AMPA-kainate (KA) receptor in this experimental paradigm.METHODS: The optic nerves of rats were crushed, and ganglion cell survival was assessed. Groups of animals were treated with an NMDA antagonist, an AMPA-KA antagonist, or both.RESULTS: The AMPA-KA antagonist DNQX was more effective, although not additive in preserving retinal ganglion cells after optic nerve crush than the NMDA antagonist MK801.CONCLUSIONS: Activation of the AMPA-KA subtype of glutamate receptor may play a role in glutamate-mediated cell death after optic nerve crush.",
keywords = "Animals, Cell Survival/drug effects, Dizocilpine Maleate/pharmacology, Excitatory Amino Acid Antagonists/pharmacology, Nerve Crush, Neuroprotective Agents/pharmacology, Optic Nerve Injuries/metabolism, Quinoxalines/pharmacology, Rats, Rats, Long-Evans, Receptors, AMPA/antagonists & inhibitors, Receptors, Kainic Acid/antagonists & inhibitors, Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors, Retinal Ganglion Cells/drug effects",
author = "F Schuettauf and R Naskar and Vorwerk, {C K} and D Zurakowski and Dreyer, {E B}",
year = "2000",
month = dec,
language = "English",
volume = "41",
pages = "4313--6",
journal = "INVEST OPHTH VIS SCI",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "13",

}

RIS

TY - JOUR

T1 - Ganglion cell loss after optic nerve crush mediated through AMPA-kainate and NMDA receptors

AU - Schuettauf, F

AU - Naskar, R

AU - Vorwerk, C K

AU - Zurakowski, D

AU - Dreyer, E B

PY - 2000/12

Y1 - 2000/12

N2 - PURPOSE: Glutamate antagonists can block ganglion cell death due to optic nerve crush. Although most investigators have focused on blockade of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor, we have chosen to evaluate the efficacy of blockade of the AMPA-kainate (KA) receptor in this experimental paradigm.METHODS: The optic nerves of rats were crushed, and ganglion cell survival was assessed. Groups of animals were treated with an NMDA antagonist, an AMPA-KA antagonist, or both.RESULTS: The AMPA-KA antagonist DNQX was more effective, although not additive in preserving retinal ganglion cells after optic nerve crush than the NMDA antagonist MK801.CONCLUSIONS: Activation of the AMPA-KA subtype of glutamate receptor may play a role in glutamate-mediated cell death after optic nerve crush.

AB - PURPOSE: Glutamate antagonists can block ganglion cell death due to optic nerve crush. Although most investigators have focused on blockade of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor, we have chosen to evaluate the efficacy of blockade of the AMPA-kainate (KA) receptor in this experimental paradigm.METHODS: The optic nerves of rats were crushed, and ganglion cell survival was assessed. Groups of animals were treated with an NMDA antagonist, an AMPA-KA antagonist, or both.RESULTS: The AMPA-KA antagonist DNQX was more effective, although not additive in preserving retinal ganglion cells after optic nerve crush than the NMDA antagonist MK801.CONCLUSIONS: Activation of the AMPA-KA subtype of glutamate receptor may play a role in glutamate-mediated cell death after optic nerve crush.

KW - Animals

KW - Cell Survival/drug effects

KW - Dizocilpine Maleate/pharmacology

KW - Excitatory Amino Acid Antagonists/pharmacology

KW - Nerve Crush

KW - Neuroprotective Agents/pharmacology

KW - Optic Nerve Injuries/metabolism

KW - Quinoxalines/pharmacology

KW - Rats

KW - Rats, Long-Evans

KW - Receptors, AMPA/antagonists & inhibitors

KW - Receptors, Kainic Acid/antagonists & inhibitors

KW - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors

KW - Retinal Ganglion Cells/drug effects

M3 - SCORING: Journal article

C2 - 11095632

VL - 41

SP - 4313

EP - 4316

JO - INVEST OPHTH VIS SCI

JF - INVEST OPHTH VIS SCI

SN - 0146-0404

IS - 13

ER -