GABA concentration in superior temporal sulcus predicts gamma power and perception in the sound-induced flash illusion
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GABA concentration in superior temporal sulcus predicts gamma power and perception in the sound-induced flash illusion. / Balz, Johanna; Keil, Julian; Roa Romero, Yadira; Mekle, Ralf; Schubert, Florian; Aydin, Semiha; Ittermann, Bernd; Gallinat, Jürgen; Senkowski, Daniel.
In: NEUROIMAGE, Vol. 125, 15.01.2016, p. 724-30.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - GABA concentration in superior temporal sulcus predicts gamma power and perception in the sound-induced flash illusion
AU - Balz, Johanna
AU - Keil, Julian
AU - Roa Romero, Yadira
AU - Mekle, Ralf
AU - Schubert, Florian
AU - Aydin, Semiha
AU - Ittermann, Bernd
AU - Gallinat, Jürgen
AU - Senkowski, Daniel
N1 - Copyright © 2015 Elsevier Inc. All rights reserved.
PY - 2016/1/15
Y1 - 2016/1/15
N2 - In everyday life we are confronted with inputs of multisensory stimuli that need to be integrated across our senses. Individuals vary considerably in how they integrate multisensory information, yet the neurochemical foundations underlying this variability are not well understood. Neural oscillations, especially in the gamma band (>30Hz) play an important role in multisensory processing. Furthermore, gamma-aminobutyric acid (GABA) neurotransmission contributes to the generation of gamma band oscillations (GBO), which can be sustained by activation of metabotropic glutamate receptors. Hence, differences in the GABA and glutamate systems might contribute to individual differences in multisensory processing. In this combined magnetic resonance spectroscopy and electroencephalography study, we examined the relationships between GABA and glutamate concentrations in the superior temporal sulcus (STS), source localized GBO, and illusion rate in the sound-induced flash illusion (SIFI). In 39 human volunteers we found robust relationships between GABA concentration, GBO power, and the SIFI perception rate (r-values=0.44 to 0.53). The correlation between GBO power and SIFI perception rate was about twofold higher when the modulating influence of the GABA level was included in the analysis as compared to when it was excluded. No significant effects were obtained for glutamate concentration. Our study suggests that the GABA level shapes individual differences in audiovisual perception through its modulating influence on GBO. GABA neurotransmission could be a promising target for treatment interventions of multisensory processing deficits in clinical populations, such as schizophrenia or autism.
AB - In everyday life we are confronted with inputs of multisensory stimuli that need to be integrated across our senses. Individuals vary considerably in how they integrate multisensory information, yet the neurochemical foundations underlying this variability are not well understood. Neural oscillations, especially in the gamma band (>30Hz) play an important role in multisensory processing. Furthermore, gamma-aminobutyric acid (GABA) neurotransmission contributes to the generation of gamma band oscillations (GBO), which can be sustained by activation of metabotropic glutamate receptors. Hence, differences in the GABA and glutamate systems might contribute to individual differences in multisensory processing. In this combined magnetic resonance spectroscopy and electroencephalography study, we examined the relationships between GABA and glutamate concentrations in the superior temporal sulcus (STS), source localized GBO, and illusion rate in the sound-induced flash illusion (SIFI). In 39 human volunteers we found robust relationships between GABA concentration, GBO power, and the SIFI perception rate (r-values=0.44 to 0.53). The correlation between GBO power and SIFI perception rate was about twofold higher when the modulating influence of the GABA level was included in the analysis as compared to when it was excluded. No significant effects were obtained for glutamate concentration. Our study suggests that the GABA level shapes individual differences in audiovisual perception through its modulating influence on GBO. GABA neurotransmission could be a promising target for treatment interventions of multisensory processing deficits in clinical populations, such as schizophrenia or autism.
U2 - 10.1016/j.neuroimage.2015.10.087
DO - 10.1016/j.neuroimage.2015.10.087
M3 - SCORING: Journal article
C2 - 26546865
VL - 125
SP - 724
EP - 730
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
ER -