Future perspective: immunomodulatory therapy for autoimmune hepatitis
Standard
Future perspective: immunomodulatory therapy for autoimmune hepatitis. / Sebode, Marcial; Lohse, Ansgar W.
In: DIGEST DIS, Vol. 32, No. 5, 01.01.2014, p. 502-506.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Future perspective: immunomodulatory therapy for autoimmune hepatitis
AU - Sebode, Marcial
AU - Lohse, Ansgar W
PY - 2014/1/1
Y1 - 2014/1/1
N2 - In the last two decades, more and more light has been shed on the immunologic pathogenesis of autoimmune liver diseases, notably autoimmune hepatitis (AIH). An immunologic dysbalance with proinflammatory immune responses dominating over hepatic tolerance seems to be part of AIH pathogenesis. In detail, an impairment of regulatory T cells (Treg) is suspected. If this holds true and reduced Treg numbers or their function are pathogenic for AIH, this offers the option of cellular or immunomodulatory therapy. However, the exact immunological role of Treg in AIH still needs to be clarified before cellular therapy is promising for patients.
AB - In the last two decades, more and more light has been shed on the immunologic pathogenesis of autoimmune liver diseases, notably autoimmune hepatitis (AIH). An immunologic dysbalance with proinflammatory immune responses dominating over hepatic tolerance seems to be part of AIH pathogenesis. In detail, an impairment of regulatory T cells (Treg) is suspected. If this holds true and reduced Treg numbers or their function are pathogenic for AIH, this offers the option of cellular or immunomodulatory therapy. However, the exact immunological role of Treg in AIH still needs to be clarified before cellular therapy is promising for patients.
KW - Hepatitis, Autoimmune
KW - Humans
KW - Immunomodulation
KW - Models, Immunological
KW - T-Lymphocytes, Regulatory
U2 - 10.1159/000360493
DO - 10.1159/000360493
M3 - SCORING: Journal article
C2 - 25034282
VL - 32
SP - 502
EP - 506
JO - DIGEST DIS
JF - DIGEST DIS
SN - 0257-2753
IS - 5
ER -