Functional studies on circulating and disseminated tumor cells in carcinoma patients

Catherine Alix-Panabières; Kai Bartkowiak; Klaus Pantel

doi:10.1016/j.molonc.2016.01.004

Functional studies on circulating and disseminated tumor cells in carcinoma patients

Standard

Functional studies on circulating and disseminated tumor cells in carcinoma patients. / Alix-Panabières, Catherine; Bartkowiak, Kai; Pantel, Klaus.

In: MOL ONCOL, Vol. 10, No. 3, 03.2016, p. 443-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Alix-Panabières, C, Bartkowiak, K & Pantel, K 2016, 'Functional studies on circulating and disseminated tumor cells in carcinoma patients', MOL ONCOL, vol. 10, no. 3, pp. 443-9. https://doi.org/10.1016/j.molonc.2016.01.004

APA

Alix-Panabières, C., Bartkowiak, K., & Pantel, K. (2016). Functional studies on circulating and disseminated tumor cells in carcinoma patients. MOL ONCOL, 10(3), 443-9. https://doi.org/10.1016/j.molonc.2016.01.004

Vancouver

Alix-Panabières C, Bartkowiak K, Pantel K. Functional studies on circulating and disseminated tumor cells in carcinoma patients. MOL ONCOL. 2016 Mar;10(3):443-9. https://doi.org/10.1016/j.molonc.2016.01.004

Bibtex

@article{46c50f0c21e74df681862770c715c52e,

title = "Functional studies on circulating and disseminated tumor cells in carcinoma patients",

abstract = "Despite numerous clinical studies indicating the clinical relevance of circulating tumor cells (CTCs) in blood and disseminated tumor cells (DTCs) in the bone marrow of cancer patients, the functional properties of these cells are largely unknown. The focus of this review is to emphasize how functional studies on viable CTCs and DTCs can enlarge the spectrum of applications of {"}liquid biopsies{"}. The low number of CTCs in the peripheral blood and DTCs in the bone marrow and the fact that carcinoma cells are difficult to culture are major challenges. Significant advances in the in vitro and in vivo expansion of CTCs and DTCs from cancer patients have been achieved, which enable us now to study the functional properties of these cells. Here, we discuss published data about functional studies on CTCs and DTCs using in vitro cultivation and in vivo xenograft models. Functional analyses on CTCs and DTCs offer the possibility to identify the metastasis-initiating cells. Moreover, CTC-derived cell lines and xenografts might point to new therapeutic targets and can be used for drug development.",

author = "Catherine Alix-Panabi{\`e}res and Kai Bartkowiak and Klaus Pantel",

year = "2016",

month = mar,

doi = "10.1016/j.molonc.2016.01.004",

language = "English",

volume = "10",

pages = "443--9",

journal = "MOL ONCOL",

issn = "1574-7891",

publisher = "Elsevier",

number = "3",

}

RIS

TY - JOUR

T1 - Functional studies on circulating and disseminated tumor cells in carcinoma patients

AU - Alix-Panabières, Catherine

AU - Bartkowiak, Kai

AU - Pantel, Klaus

PY - 2016/3

Y1 - 2016/3

N2 - Despite numerous clinical studies indicating the clinical relevance of circulating tumor cells (CTCs) in blood and disseminated tumor cells (DTCs) in the bone marrow of cancer patients, the functional properties of these cells are largely unknown. The focus of this review is to emphasize how functional studies on viable CTCs and DTCs can enlarge the spectrum of applications of "liquid biopsies". The low number of CTCs in the peripheral blood and DTCs in the bone marrow and the fact that carcinoma cells are difficult to culture are major challenges. Significant advances in the in vitro and in vivo expansion of CTCs and DTCs from cancer patients have been achieved, which enable us now to study the functional properties of these cells. Here, we discuss published data about functional studies on CTCs and DTCs using in vitro cultivation and in vivo xenograft models. Functional analyses on CTCs and DTCs offer the possibility to identify the metastasis-initiating cells. Moreover, CTC-derived cell lines and xenografts might point to new therapeutic targets and can be used for drug development.

AB - Despite numerous clinical studies indicating the clinical relevance of circulating tumor cells (CTCs) in blood and disseminated tumor cells (DTCs) in the bone marrow of cancer patients, the functional properties of these cells are largely unknown. The focus of this review is to emphasize how functional studies on viable CTCs and DTCs can enlarge the spectrum of applications of "liquid biopsies". The low number of CTCs in the peripheral blood and DTCs in the bone marrow and the fact that carcinoma cells are difficult to culture are major challenges. Significant advances in the in vitro and in vivo expansion of CTCs and DTCs from cancer patients have been achieved, which enable us now to study the functional properties of these cells. Here, we discuss published data about functional studies on CTCs and DTCs using in vitro cultivation and in vivo xenograft models. Functional analyses on CTCs and DTCs offer the possibility to identify the metastasis-initiating cells. Moreover, CTC-derived cell lines and xenografts might point to new therapeutic targets and can be used for drug development.

U2 - 10.1016/j.molonc.2016.01.004

DO - 10.1016/j.molonc.2016.01.004

M3 - SCORING: Journal article

C2 - 26847851

VL - 10

SP - 443

EP - 449

JO - MOL ONCOL

JF - MOL ONCOL

SN - 1574-7891

IS - 3

ER -