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Functional Relevance and Structural Correlates of Near Infrared and Short Wavelength Fundus Autofluorescence Imaging in ABCA4-Related Retinopathy

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Functional Relevance and Structural Correlates of Near Infrared and Short Wavelength Fundus Autofluorescence Imaging in ABCA4-Related Retinopathy. / Müller, Philipp L; Birtel, Johannes; Herrmann, Philipp; Holz, Frank G; Charbel Issa, Peter; Gliem, Martin.

In: TRANSL VIS SCI TECHN, Vol. 8, No. 6, 11.2019, p. 46.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Müller, PL, Birtel, J, Herrmann, P, Holz, FG, Charbel Issa, P & Gliem, M 2019, 'Functional Relevance and Structural Correlates of Near Infrared and Short Wavelength Fundus Autofluorescence Imaging in ABCA4-Related Retinopathy', TRANSL VIS SCI TECHN, vol. 8, no. 6, pp. 46. https://doi.org/10.1167/tvst.8.6.46

APA

Müller, P. L., Birtel, J., Herrmann, P., Holz, F. G., Charbel Issa, P., & Gliem, M. (2019). Functional Relevance and Structural Correlates of Near Infrared and Short Wavelength Fundus Autofluorescence Imaging in ABCA4-Related Retinopathy. TRANSL VIS SCI TECHN, 8(6), 46. https://doi.org/10.1167/tvst.8.6.46

Vancouver

Müller PL, Birtel J, Herrmann P, Holz FG, Charbel Issa P, Gliem M. Functional Relevance and Structural Correlates of Near Infrared and Short Wavelength Fundus Autofluorescence Imaging in ABCA4-Related Retinopathy. TRANSL VIS SCI TECHN. 2019 Nov;8(6):46. https://doi.org/10.1167/tvst.8.6.46

Bibtex

@article{fd483872696d4436b74c0ed0ebc3b9f9,
title = "Functional Relevance and Structural Correlates of Near Infrared and Short Wavelength Fundus Autofluorescence Imaging in ABCA4-Related Retinopathy",
abstract = "PURPOSE: To evaluate the functional relevance and structural correlates of autofluorescence (AF) alterations under short-wavelength (SW) and near-infrared (NIR) excitation light in ABCA4-related retinopathy.METHODS: In this prospective, cross-sectional case series, 88 eyes of 44 patients with ABCA4-related retinopathy (mean age, 37.6 years; range, 9-77 years) underwent SW-AF and NIR-AF imaging. The AF images were graded for disease characteristic patterns by two independent readers and correlated with alterations in optical coherence tomography (OCT) and impairment of retinal sensitivity along a foveo-papillary line assessed by fundus-controlled microperimetry.RESULTS: A centrifugal sequence of AF patterns from atrophic lesions to homogeneous background was found for both AF modalities. The eccentricity of each AF pattern in NIR-AF was larger compared to those in SW-AF (P < 0.001). Increasing eccentricity of each pattern correlated with increasing retinal sensitivity. The distant border of the zone of hyperfluorescent flecks in SW-AF and hypoautofluorescent flecks in NIR-AF correlated with the margins of the ellipsoid zone loss in OCT (r = 0.979 and r = 0.971, P < 0.001). The expansion of hypofluorescent flecks in SW-AF was associated with the boundaries of external limiting membrane loss (r = 0.933, P < 0.001).CONCLUSIONS: SW-AF and NIR-AF revealed a characteristic sequence of AF patterns that correlated with functional and structural alterations, suggesting different stages in disease progression.TRANSLATIONAL RELEVANCE: Alterations in NIR-AF exceeded those in SW-AF images, substantiating the hypothesis of different AF origins and suggesting NIR-AF as surrogate marker for early disease-related changes.",
author = "M{\"u}ller, {Philipp L} and Johannes Birtel and Philipp Herrmann and Holz, {Frank G} and {Charbel Issa}, Peter and Martin Gliem",
note = "Copyright 2019 The Authors.",
year = "2019",
month = nov,
doi = "10.1167/tvst.8.6.46",
language = "English",
volume = "8",
pages = "46",
journal = "TRANSL VIS SCI TECHN",
issn = "2164-2591",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Functional Relevance and Structural Correlates of Near Infrared and Short Wavelength Fundus Autofluorescence Imaging in ABCA4-Related Retinopathy

AU - Müller, Philipp L

AU - Birtel, Johannes

AU - Herrmann, Philipp

AU - Holz, Frank G

AU - Charbel Issa, Peter

AU - Gliem, Martin

N1 - Copyright 2019 The Authors.

PY - 2019/11

Y1 - 2019/11

N2 - PURPOSE: To evaluate the functional relevance and structural correlates of autofluorescence (AF) alterations under short-wavelength (SW) and near-infrared (NIR) excitation light in ABCA4-related retinopathy.METHODS: In this prospective, cross-sectional case series, 88 eyes of 44 patients with ABCA4-related retinopathy (mean age, 37.6 years; range, 9-77 years) underwent SW-AF and NIR-AF imaging. The AF images were graded for disease characteristic patterns by two independent readers and correlated with alterations in optical coherence tomography (OCT) and impairment of retinal sensitivity along a foveo-papillary line assessed by fundus-controlled microperimetry.RESULTS: A centrifugal sequence of AF patterns from atrophic lesions to homogeneous background was found for both AF modalities. The eccentricity of each AF pattern in NIR-AF was larger compared to those in SW-AF (P < 0.001). Increasing eccentricity of each pattern correlated with increasing retinal sensitivity. The distant border of the zone of hyperfluorescent flecks in SW-AF and hypoautofluorescent flecks in NIR-AF correlated with the margins of the ellipsoid zone loss in OCT (r = 0.979 and r = 0.971, P < 0.001). The expansion of hypofluorescent flecks in SW-AF was associated with the boundaries of external limiting membrane loss (r = 0.933, P < 0.001).CONCLUSIONS: SW-AF and NIR-AF revealed a characteristic sequence of AF patterns that correlated with functional and structural alterations, suggesting different stages in disease progression.TRANSLATIONAL RELEVANCE: Alterations in NIR-AF exceeded those in SW-AF images, substantiating the hypothesis of different AF origins and suggesting NIR-AF as surrogate marker for early disease-related changes.

AB - PURPOSE: To evaluate the functional relevance and structural correlates of autofluorescence (AF) alterations under short-wavelength (SW) and near-infrared (NIR) excitation light in ABCA4-related retinopathy.METHODS: In this prospective, cross-sectional case series, 88 eyes of 44 patients with ABCA4-related retinopathy (mean age, 37.6 years; range, 9-77 years) underwent SW-AF and NIR-AF imaging. The AF images were graded for disease characteristic patterns by two independent readers and correlated with alterations in optical coherence tomography (OCT) and impairment of retinal sensitivity along a foveo-papillary line assessed by fundus-controlled microperimetry.RESULTS: A centrifugal sequence of AF patterns from atrophic lesions to homogeneous background was found for both AF modalities. The eccentricity of each AF pattern in NIR-AF was larger compared to those in SW-AF (P < 0.001). Increasing eccentricity of each pattern correlated with increasing retinal sensitivity. The distant border of the zone of hyperfluorescent flecks in SW-AF and hypoautofluorescent flecks in NIR-AF correlated with the margins of the ellipsoid zone loss in OCT (r = 0.979 and r = 0.971, P < 0.001). The expansion of hypofluorescent flecks in SW-AF was associated with the boundaries of external limiting membrane loss (r = 0.933, P < 0.001).CONCLUSIONS: SW-AF and NIR-AF revealed a characteristic sequence of AF patterns that correlated with functional and structural alterations, suggesting different stages in disease progression.TRANSLATIONAL RELEVANCE: Alterations in NIR-AF exceeded those in SW-AF images, substantiating the hypothesis of different AF origins and suggesting NIR-AF as surrogate marker for early disease-related changes.

U2 - 10.1167/tvst.8.6.46

DO - 10.1167/tvst.8.6.46

M3 - SCORING: Journal article

C2 - 31879568

VL - 8

SP - 46

JO - TRANSL VIS SCI TECHN

JF - TRANSL VIS SCI TECHN

SN - 2164-2591

IS - 6

ER -