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Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women

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Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women. / Mutschler, Jochen; Abbruzzese, Elvira; Wiedemann, Klaus; von der Goltz, Christoph; Dinter, Christina; Mobascher, Arian; Thiele, Holger; Diaz-Lacava, Amalia; Dahmen, Norbert; Gallinat, Jürgen; Majic, Tomislav; Petrovsky, Nadine; Thuerauf, Norbert; Kornhuber, Johannes; Gründer, Gerhard; Rademacher, Lena; Brinkmeyer, Juergen; Wienker, Thomas; Wagner, Michael; Winterer, Georg; Kiefer, Falk.

In: ANN NUTR METAB, Vol. 62, No. 4, 01.01.2013, p. 271-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mutschler, J, Abbruzzese, E, Wiedemann, K, von der Goltz, C, Dinter, C, Mobascher, A, Thiele, H, Diaz-Lacava, A, Dahmen, N, Gallinat, J, Majic, T, Petrovsky, N, Thuerauf, N, Kornhuber, J, Gründer, G, Rademacher, L, Brinkmeyer, J, Wienker, T, Wagner, M, Winterer, G & Kiefer, F 2013, 'Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women', ANN NUTR METAB, vol. 62, no. 4, pp. 271-6. https://doi.org/10.1159/000346799

APA

Mutschler, J., Abbruzzese, E., Wiedemann, K., von der Goltz, C., Dinter, C., Mobascher, A., Thiele, H., Diaz-Lacava, A., Dahmen, N., Gallinat, J., Majic, T., Petrovsky, N., Thuerauf, N., Kornhuber, J., Gründer, G., Rademacher, L., Brinkmeyer, J., Wienker, T., Wagner, M., ... Kiefer, F. (2013). Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women. ANN NUTR METAB, 62(4), 271-6. https://doi.org/10.1159/000346799

Vancouver

Mutschler J, Abbruzzese E, Wiedemann K, von der Goltz C, Dinter C, Mobascher A et al. Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women. ANN NUTR METAB. 2013 Jan 1;62(4):271-6. https://doi.org/10.1159/000346799

Bibtex

@article{ef5b54f8339f47008275bba35544cc75,
title = "Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women",
abstract = "OBJECTIVE: The neuropeptide-Y (NP-Y) gene is a strong candidate gene in the pathophysiology of obesity-linked behavior, and several single-nucleotide polymorphisms of NP-Y have already been linked to body weight and appetite. However, the results from current studies remain inconclusive. The aim of the present study was to test whether a certain functional genetic variant (SNP rs16147) in the NP-Y promoter gene is associated with serum leptin levels and body fat distribution.METHOD: We genotyped and measured the serum leptin levels of the NP-Y rs16147 polymorphism in 1,097 Caucasian subjects in the context of a population-based, case-control multicenter study. We measured weight, height and waist circumference, from which we then calculated BMI and waist-to-hip ratio (WHR).RESULTS: We found the CT-genotype of the SNP rs16147 to be significantly associated with lower WHRs and higher serum leptin levels in women, compared to homozygote gene carriers. No association between rs16147, WHR and serum leptin levels was found in men.CONCLUSION: Our results provide evidence that the functionally relevant SNP in the NP-Y promoter gene affects body fat distribution and serum leptin levels in women, pointing towards possible behavioral effects of NPY in obesity.",
keywords = "Adult, Case-Control Studies, European Continental Ancestry Group, Female, Genotype, Humans, Leptin, Male, Middle Aged, Neuropeptide Y, Obesity, Polymorphism, Single Nucleotide, Sex Factors, Statistics, Nonparametric, Waist-Hip Ratio",
author = "Jochen Mutschler and Elvira Abbruzzese and Klaus Wiedemann and {von der Goltz}, Christoph and Christina Dinter and Arian Mobascher and Holger Thiele and Amalia Diaz-Lacava and Norbert Dahmen and J{\"u}rgen Gallinat and Tomislav Majic and Nadine Petrovsky and Norbert Thuerauf and Johannes Kornhuber and Gerhard Gr{\"u}nder and Lena Rademacher and Juergen Brinkmeyer and Thomas Wienker and Michael Wagner and Georg Winterer and Falk Kiefer",
note = "Copyright {\textcopyright} 2013 S. Karger AG, Basel.",
year = "2013",
month = jan,
day = "1",
doi = "10.1159/000346799",
language = "English",
volume = "62",
pages = "271--6",
journal = "ANN NUTR METAB",
issn = "0250-6807",
publisher = "S. Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women

AU - Mutschler, Jochen

AU - Abbruzzese, Elvira

AU - Wiedemann, Klaus

AU - von der Goltz, Christoph

AU - Dinter, Christina

AU - Mobascher, Arian

AU - Thiele, Holger

AU - Diaz-Lacava, Amalia

AU - Dahmen, Norbert

AU - Gallinat, Jürgen

AU - Majic, Tomislav

AU - Petrovsky, Nadine

AU - Thuerauf, Norbert

AU - Kornhuber, Johannes

AU - Gründer, Gerhard

AU - Rademacher, Lena

AU - Brinkmeyer, Juergen

AU - Wienker, Thomas

AU - Wagner, Michael

AU - Winterer, Georg

AU - Kiefer, Falk

N1 - Copyright © 2013 S. Karger AG, Basel.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - OBJECTIVE: The neuropeptide-Y (NP-Y) gene is a strong candidate gene in the pathophysiology of obesity-linked behavior, and several single-nucleotide polymorphisms of NP-Y have already been linked to body weight and appetite. However, the results from current studies remain inconclusive. The aim of the present study was to test whether a certain functional genetic variant (SNP rs16147) in the NP-Y promoter gene is associated with serum leptin levels and body fat distribution.METHOD: We genotyped and measured the serum leptin levels of the NP-Y rs16147 polymorphism in 1,097 Caucasian subjects in the context of a population-based, case-control multicenter study. We measured weight, height and waist circumference, from which we then calculated BMI and waist-to-hip ratio (WHR).RESULTS: We found the CT-genotype of the SNP rs16147 to be significantly associated with lower WHRs and higher serum leptin levels in women, compared to homozygote gene carriers. No association between rs16147, WHR and serum leptin levels was found in men.CONCLUSION: Our results provide evidence that the functionally relevant SNP in the NP-Y promoter gene affects body fat distribution and serum leptin levels in women, pointing towards possible behavioral effects of NPY in obesity.

AB - OBJECTIVE: The neuropeptide-Y (NP-Y) gene is a strong candidate gene in the pathophysiology of obesity-linked behavior, and several single-nucleotide polymorphisms of NP-Y have already been linked to body weight and appetite. However, the results from current studies remain inconclusive. The aim of the present study was to test whether a certain functional genetic variant (SNP rs16147) in the NP-Y promoter gene is associated with serum leptin levels and body fat distribution.METHOD: We genotyped and measured the serum leptin levels of the NP-Y rs16147 polymorphism in 1,097 Caucasian subjects in the context of a population-based, case-control multicenter study. We measured weight, height and waist circumference, from which we then calculated BMI and waist-to-hip ratio (WHR).RESULTS: We found the CT-genotype of the SNP rs16147 to be significantly associated with lower WHRs and higher serum leptin levels in women, compared to homozygote gene carriers. No association between rs16147, WHR and serum leptin levels was found in men.CONCLUSION: Our results provide evidence that the functionally relevant SNP in the NP-Y promoter gene affects body fat distribution and serum leptin levels in women, pointing towards possible behavioral effects of NPY in obesity.

KW - Adult

KW - Case-Control Studies

KW - European Continental Ancestry Group

KW - Female

KW - Genotype

KW - Humans

KW - Leptin

KW - Male

KW - Middle Aged

KW - Neuropeptide Y

KW - Obesity

KW - Polymorphism, Single Nucleotide

KW - Sex Factors

KW - Statistics, Nonparametric

KW - Waist-Hip Ratio

U2 - 10.1159/000346799

DO - 10.1159/000346799

M3 - SCORING: Journal article

C2 - 23652383

VL - 62

SP - 271

EP - 276

JO - ANN NUTR METAB

JF - ANN NUTR METAB

SN - 0250-6807

IS - 4

ER -