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Functional network connectivity is altered in patients with upper limb somatosensory impairments in the acute phase post stroke: A cross-sectional study

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Functional network connectivity is altered in patients with upper limb somatosensory impairments in the acute phase post stroke: A cross-sectional study. / De Bruyn, Nele; Meyer, Sarah; Kessner, Simon S; Essers, Bea; Cheng, Bastian; Thomalla, Götz; Peeters, Andre; Sunaert, Stefan; Duprez, Thierry; Thijs, Vincent; Feys, Hilde; Alaerts, Kaat; Verheyden, Geert.

In: PLOS ONE, Vol. 13, No. 10, 12.10.2018, p. e0205693.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

De Bruyn, N, Meyer, S, Kessner, SS, Essers, B, Cheng, B, Thomalla, G, Peeters, A, Sunaert, S, Duprez, T, Thijs, V, Feys, H, Alaerts, K & Verheyden, G 2018, 'Functional network connectivity is altered in patients with upper limb somatosensory impairments in the acute phase post stroke: A cross-sectional study', PLOS ONE, vol. 13, no. 10, pp. e0205693. https://doi.org/10.1371/journal.pone.0205693

APA

De Bruyn, N., Meyer, S., Kessner, S. S., Essers, B., Cheng, B., Thomalla, G., Peeters, A., Sunaert, S., Duprez, T., Thijs, V., Feys, H., Alaerts, K., & Verheyden, G. (2018). Functional network connectivity is altered in patients with upper limb somatosensory impairments in the acute phase post stroke: A cross-sectional study. PLOS ONE, 13(10), e0205693. https://doi.org/10.1371/journal.pone.0205693

Vancouver

De Bruyn N, Meyer S, Kessner SS, Essers B, Cheng B, Thomalla G et al. Functional network connectivity is altered in patients with upper limb somatosensory impairments in the acute phase post stroke: A cross-sectional study. PLOS ONE. 2018 Oct 12;13(10):e0205693. https://doi.org/10.1371/journal.pone.0205693

Bibtex

@article{a3c5bb26bcd642789f3bd2c2602799b7,
title = "Functional network connectivity is altered in patients with upper limb somatosensory impairments in the acute phase post stroke: A cross-sectional study",
abstract = "BACKGROUND: Aberrant functional connectivity in brain networks associated with motor impairment after stroke is well described, but little is known about the association with somatosensory impairments.AIM: The objective of this cross-sectional observational study was to investigate the relationship between brain functional connectivity and severity of somatosensory impairments in the upper limb in the acute phase post stroke.METHODS: Nineteen first-ever stroke patients underwent resting-state functional magnetic resonance imaging (rs-fMRI) and a standardized clinical somatosensory profile assessment (exteroception and higher cortical somatosensation) in the first week post stroke. Integrity of inter- and intrahemispheric (ipsilesional and contralesional) functional connectivity of the somatosensory network was assessed between patients with severe (Em-NSA< 13/32) and mild to moderate (Em-NSA> 13/32) somatosensory impairments.RESULTS: Patients with severe somatosensory impairments displayed significantly lower functional connectivity indices in terms of interhemispheric (p = 0.001) and ipsilesional intrahemispheric (p = 0.035) connectivity compared to mildly to moderately impaired patients. Significant associations were found between the perceptual threshold of touch assessment and interhemispheric (r = -0.63) and ipsilesional (r = -0.51) network indices. Additional significant associations were found between the index of interhemispheric connectivity and light touch (r = 0.55) and stereognosis (r = 0.64) evaluation.CONCLUSION: Patients with more severe somatosensory impairments have lower inter- and ipsilesional intrahemispheric connectivity of the somatosensory network. Lower connectivity indices are related to more impaired exteroception and higher cortical somatosensation. This study highlights the importance of network integrity in terms of inter- and ipsilesional intrahemispheric connectivity for somatosensory function. Further research is needed investigating the effect of therapy on the re-establishment of these networks.",
keywords = "Journal Article",
author = "{De Bruyn}, Nele and Sarah Meyer and Kessner, {Simon S} and Bea Essers and Bastian Cheng and G{\"o}tz Thomalla and Andre Peeters and Stefan Sunaert and Thierry Duprez and Vincent Thijs and Hilde Feys and Kaat Alaerts and Geert Verheyden",
year = "2018",
month = oct,
day = "12",
doi = "10.1371/journal.pone.0205693",
language = "English",
volume = "13",
pages = "e0205693",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

RIS

TY - JOUR

T1 - Functional network connectivity is altered in patients with upper limb somatosensory impairments in the acute phase post stroke: A cross-sectional study

AU - De Bruyn, Nele

AU - Meyer, Sarah

AU - Kessner, Simon S

AU - Essers, Bea

AU - Cheng, Bastian

AU - Thomalla, Götz

AU - Peeters, Andre

AU - Sunaert, Stefan

AU - Duprez, Thierry

AU - Thijs, Vincent

AU - Feys, Hilde

AU - Alaerts, Kaat

AU - Verheyden, Geert

PY - 2018/10/12

Y1 - 2018/10/12

N2 - BACKGROUND: Aberrant functional connectivity in brain networks associated with motor impairment after stroke is well described, but little is known about the association with somatosensory impairments.AIM: The objective of this cross-sectional observational study was to investigate the relationship between brain functional connectivity and severity of somatosensory impairments in the upper limb in the acute phase post stroke.METHODS: Nineteen first-ever stroke patients underwent resting-state functional magnetic resonance imaging (rs-fMRI) and a standardized clinical somatosensory profile assessment (exteroception and higher cortical somatosensation) in the first week post stroke. Integrity of inter- and intrahemispheric (ipsilesional and contralesional) functional connectivity of the somatosensory network was assessed between patients with severe (Em-NSA< 13/32) and mild to moderate (Em-NSA> 13/32) somatosensory impairments.RESULTS: Patients with severe somatosensory impairments displayed significantly lower functional connectivity indices in terms of interhemispheric (p = 0.001) and ipsilesional intrahemispheric (p = 0.035) connectivity compared to mildly to moderately impaired patients. Significant associations were found between the perceptual threshold of touch assessment and interhemispheric (r = -0.63) and ipsilesional (r = -0.51) network indices. Additional significant associations were found between the index of interhemispheric connectivity and light touch (r = 0.55) and stereognosis (r = 0.64) evaluation.CONCLUSION: Patients with more severe somatosensory impairments have lower inter- and ipsilesional intrahemispheric connectivity of the somatosensory network. Lower connectivity indices are related to more impaired exteroception and higher cortical somatosensation. This study highlights the importance of network integrity in terms of inter- and ipsilesional intrahemispheric connectivity for somatosensory function. Further research is needed investigating the effect of therapy on the re-establishment of these networks.

AB - BACKGROUND: Aberrant functional connectivity in brain networks associated with motor impairment after stroke is well described, but little is known about the association with somatosensory impairments.AIM: The objective of this cross-sectional observational study was to investigate the relationship between brain functional connectivity and severity of somatosensory impairments in the upper limb in the acute phase post stroke.METHODS: Nineteen first-ever stroke patients underwent resting-state functional magnetic resonance imaging (rs-fMRI) and a standardized clinical somatosensory profile assessment (exteroception and higher cortical somatosensation) in the first week post stroke. Integrity of inter- and intrahemispheric (ipsilesional and contralesional) functional connectivity of the somatosensory network was assessed between patients with severe (Em-NSA< 13/32) and mild to moderate (Em-NSA> 13/32) somatosensory impairments.RESULTS: Patients with severe somatosensory impairments displayed significantly lower functional connectivity indices in terms of interhemispheric (p = 0.001) and ipsilesional intrahemispheric (p = 0.035) connectivity compared to mildly to moderately impaired patients. Significant associations were found between the perceptual threshold of touch assessment and interhemispheric (r = -0.63) and ipsilesional (r = -0.51) network indices. Additional significant associations were found between the index of interhemispheric connectivity and light touch (r = 0.55) and stereognosis (r = 0.64) evaluation.CONCLUSION: Patients with more severe somatosensory impairments have lower inter- and ipsilesional intrahemispheric connectivity of the somatosensory network. Lower connectivity indices are related to more impaired exteroception and higher cortical somatosensation. This study highlights the importance of network integrity in terms of inter- and ipsilesional intrahemispheric connectivity for somatosensory function. Further research is needed investigating the effect of therapy on the re-establishment of these networks.

KW - Journal Article

U2 - 10.1371/journal.pone.0205693

DO - 10.1371/journal.pone.0205693

M3 - SCORING: Journal article

C2 - 30312350

VL - 13

SP - e0205693

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 10

ER -