Functional magnetic resonance imaging and treatment strategies in schizophrenia.
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Functional magnetic resonance imaging and treatment strategies in schizophrenia. / Karch, Susanne; Pogarell, Oliver; Mulert, Christoph.
In: CURR PHARM BIOTECHNO, Vol. 13, No. 8, 8, 2012, p. 1622-1629.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Functional magnetic resonance imaging and treatment strategies in schizophrenia.
AU - Karch, Susanne
AU - Pogarell, Oliver
AU - Mulert, Christoph
PY - 2012
Y1 - 2012
N2 - Neurobiological correlates of various treatment approaches (e.g. psychopharmacology, cognitive behavioural therapy) have become an important issue in recent neuroimaging studies. In schizophrenia, dysfunctions especially in frontal and parietal brain regions as well as the ventral striatum have been demonstrated in numerous studies. The review includes functional MRI studies about neurobiological correlates of treatment effects in schizophrenic patients. Treatment-associated changes in brain activity were shown especially in the anterior cingulate cortex, the dorsolateral prefrontal cortex, the ventral striatum and the amygdala. In addition, the differential effects of various treatment approaches including different neuroleptics (atypical neuroleptics, typical neuroleptics) as well as cognitive behavioural therapy will be considered in this review. The influence of functional differences on the differential effect of typical and atypical antipsychotics on cognitive functions will be discussed.
AB - Neurobiological correlates of various treatment approaches (e.g. psychopharmacology, cognitive behavioural therapy) have become an important issue in recent neuroimaging studies. In schizophrenia, dysfunctions especially in frontal and parietal brain regions as well as the ventral striatum have been demonstrated in numerous studies. The review includes functional MRI studies about neurobiological correlates of treatment effects in schizophrenic patients. Treatment-associated changes in brain activity were shown especially in the anterior cingulate cortex, the dorsolateral prefrontal cortex, the ventral striatum and the amygdala. In addition, the differential effects of various treatment approaches including different neuroleptics (atypical neuroleptics, typical neuroleptics) as well as cognitive behavioural therapy will be considered in this review. The influence of functional differences on the differential effect of typical and atypical antipsychotics on cognitive functions will be discussed.
KW - Animals
KW - Humans
KW - Cognitive Therapy
KW - Schizophrenic Psychology
KW - Magnetic Resonance Imaging
KW - Antipsychotic Agents/therapeutic use
KW - Schizophrenia/physiopathology/therapy
KW - Animals
KW - Humans
KW - Cognitive Therapy
KW - Schizophrenic Psychology
KW - Magnetic Resonance Imaging
KW - Antipsychotic Agents/therapeutic use
KW - Schizophrenia/physiopathology/therapy
M3 - SCORING: Journal article
VL - 13
SP - 1622
EP - 1629
JO - CURR PHARM BIOTECHNO
JF - CURR PHARM BIOTECHNO
SN - 1389-2010
IS - 8
M1 - 8
ER -