Functional heterogeneity of CD4+ T cells in liver inflammation

Franziska Muscate; Anna Woestemeier; Nicola Gagliani

doi:10.1007/s00281-021-00881-w

Functional heterogeneity of CD4+ T cells in liver inflammation

Standard

Functional heterogeneity of CD4+ T cells in liver inflammation. / Muscate, Franziska; Woestemeier, Anna; Gagliani, Nicola.

In: SEMIN IMMUNOPATHOL, Vol. 43, No. 4, 08.2021, p. 549-561.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Muscate, F, Woestemeier, A & Gagliani, N 2021, 'Functional heterogeneity of CD4+ T cells in liver inflammation', SEMIN IMMUNOPATHOL, vol. 43, no. 4, pp. 549-561. https://doi.org/10.1007/s00281-021-00881-w

APA

Muscate, F., Woestemeier, A., & Gagliani, N. (2021). Functional heterogeneity of CD4+ T cells in liver inflammation. SEMIN IMMUNOPATHOL, 43(4), 549-561. https://doi.org/10.1007/s00281-021-00881-w

Vancouver

Muscate F, Woestemeier A, Gagliani N. Functional heterogeneity of CD4+ T cells in liver inflammation. SEMIN IMMUNOPATHOL. 2021 Aug;43(4):549-561. https://doi.org/10.1007/s00281-021-00881-w

Bibtex

@article{9a5e767444fc45d4b7e265979d1e447f,

title = "Functional heterogeneity of CD4+ T cells in liver inflammation",

abstract = "CD4+ T cells play an essential role in orchestrating adequate immunity, but their overactivity has been associated with the development of immune-mediated inflammatory diseases, including liver inflammatory diseases. These cells can be subclassified according to their maturation stage, cytokine profile, and pro or anti-inflammatory functions, i.e., functional heterogeneity. In this review, we summarize what has been discovered so far regarding the role of the different CD4+ T cell polarization states in the progression of two prominent and still different liver inflammatory diseases: non-alcoholic steatohepatitis (NASH) and autoimmune hepatitis (AIH). Finally, the potential of CD4+ T cells as a therapeutic target in both NASH and AIH is discussed.",

keywords = "CD4-Positive T-Lymphocytes, Hepatitis, Autoimmune, Humans, Inflammation/etiology, Liver, Non-alcoholic Fatty Liver Disease, T-Lymphocytes",

author = "Franziska Muscate and Anna Woestemeier and Nicola Gagliani",

note = "{\textcopyright} 2021. The Author(s).",

year = "2021",

month = aug,

doi = "10.1007/s00281-021-00881-w",

language = "English",

volume = "43",

pages = "549--561",

journal = "SEMIN IMMUNOPATHOL",

issn = "1863-2297",

publisher = "Springer",

number = "4",

}

RIS

TY - JOUR

T1 - Functional heterogeneity of CD4+ T cells in liver inflammation

AU - Muscate, Franziska

AU - Woestemeier, Anna

AU - Gagliani, Nicola

PY - 2021/8

Y1 - 2021/8

N2 - CD4+ T cells play an essential role in orchestrating adequate immunity, but their overactivity has been associated with the development of immune-mediated inflammatory diseases, including liver inflammatory diseases. These cells can be subclassified according to their maturation stage, cytokine profile, and pro or anti-inflammatory functions, i.e., functional heterogeneity. In this review, we summarize what has been discovered so far regarding the role of the different CD4+ T cell polarization states in the progression of two prominent and still different liver inflammatory diseases: non-alcoholic steatohepatitis (NASH) and autoimmune hepatitis (AIH). Finally, the potential of CD4+ T cells as a therapeutic target in both NASH and AIH is discussed.

AB - CD4+ T cells play an essential role in orchestrating adequate immunity, but their overactivity has been associated with the development of immune-mediated inflammatory diseases, including liver inflammatory diseases. These cells can be subclassified according to their maturation stage, cytokine profile, and pro or anti-inflammatory functions, i.e., functional heterogeneity. In this review, we summarize what has been discovered so far regarding the role of the different CD4+ T cell polarization states in the progression of two prominent and still different liver inflammatory diseases: non-alcoholic steatohepatitis (NASH) and autoimmune hepatitis (AIH). Finally, the potential of CD4+ T cells as a therapeutic target in both NASH and AIH is discussed.

KW - CD4-Positive T-Lymphocytes

KW - Hepatitis, Autoimmune

KW - Humans

KW - Inflammation/etiology

KW - Liver

KW - Non-alcoholic Fatty Liver Disease

KW - T-Lymphocytes

U2 - 10.1007/s00281-021-00881-w

DO - 10.1007/s00281-021-00881-w

M3 - SCORING: Review article

C2 - 34463867

VL - 43

SP - 549

EP - 561

JO - SEMIN IMMUNOPATHOL

JF - SEMIN IMMUNOPATHOL

SN - 1863-2297

IS - 4

ER -