Functional evaluation of intracranial atherosclerotic stenosis by pressure ratio measurements

Ming Wang; Xiaochang Leng; Baojie Mao; Rong Zou; Dongdong Lin; Yuhai Gao; Ning Wang; Yuning Lu; Jens Fiehler; Adnan H Siddiqui; Jiong Wu; Jianping Xiang; Shu Wan

doi:10.1016/j.heliyon.2023.e13527

Functional evaluation of intracranial atherosclerotic stenosis by pressure ratio measurements

Standard

Functional evaluation of intracranial atherosclerotic stenosis by pressure ratio measurements. / Wang, Ming; Leng, Xiaochang; Mao, Baojie; Zou, Rong; Lin, Dongdong; Gao, Yuhai; Wang, Ning; Lu, Yuning; Fiehler, Jens; Siddiqui, Adnan H; Wu, Jiong; Xiang, Jianping; Wan, Shu.

In: HELIYON, Vol. 9, No. 2, 02.2023, p. e13527.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wang, M, Leng, X, Mao, B, Zou, R, Lin, D, Gao, Y, Wang, N, Lu, Y, Fiehler, J, Siddiqui, AH, Wu, J, Xiang, J & Wan, S 2023, 'Functional evaluation of intracranial atherosclerotic stenosis by pressure ratio measurements', HELIYON, vol. 9, no. 2, pp. e13527. https://doi.org/10.1016/j.heliyon.2023.e13527

APA

Wang, M., Leng, X., Mao, B., Zou, R., Lin, D., Gao, Y., Wang, N., Lu, Y., Fiehler, J., Siddiqui, A. H., Wu, J., Xiang, J., & Wan, S. (2023). Functional evaluation of intracranial atherosclerotic stenosis by pressure ratio measurements. HELIYON, 9(2), e13527. https://doi.org/10.1016/j.heliyon.2023.e13527

Vancouver

Wang M, Leng X, Mao B, Zou R, Lin D, Gao Y et al. Functional evaluation of intracranial atherosclerotic stenosis by pressure ratio measurements. HELIYON. 2023 Feb;9(2):e13527. https://doi.org/10.1016/j.heliyon.2023.e13527

Bibtex

@article{6215054bf4824dc781670e013ff2f7ee,

title = "Functional evaluation of intracranial atherosclerotic stenosis by pressure ratio measurements",

abstract = "BACKGROUND: Fractional flow reserve is widely used for the functional evaluation of coronary artery stenosis. Some studies have similarly used the translesional pressure ratio measurements for the functional evaluation of intracranial atherosclerotic stenosis. In this paper, we aimed to investigate the relationship between pressure ratio and cerebral tissue perfusion by MR perfusion imaging and provided a non-invasive method for evaluating the functional significance of intracranial atherosclerotic stenosis.METHODS: A total of 18 consecutive patients with intracranial atherosclerotic stenosis patients including 19 stenotic vessels were recruited. The pressure was measured using a pressure guidewire, the pressure ratio before and after the endovascular intervention was calculated and compared with the severity of diameter stenosis and perfusion-derived MR (the time to maximum tissure residue function (Tmax)). Moreover, the DSA-derived pressure ratio was computed using a novel computational fluid dynamics-based model, termed CFD-PR, and was compared with the actual pressure ratio to assess its diagnostic accuracy.RESULTS: The pressure ratio increased after percutaneous transluminal angioplasty or stenting, while the correlation between pressure ratio and diameter stenosis was not significant. The pressure ratio was negatively correlated with Tmax (r = -0.73, P < 0.01), and a 95% confidence interval for the cutoff value of pressure ratio = 0.67 (95% confidence interval: 0.58-0.76) was suggested. There was a good correlation (mean = 0.02, Spearman's correlation coefficient r = 0.908, P < 0.001) and agreement (limits of agreement: -0.157 to 0.196, P = 0.954) between CFD-PR and the actual pressure ratio.CONCLUSIONS: This exploratory study indicates the pressure ratio may correlate with the perfusion status. The pressure ratio can be calculated through a non-invasive method using a computational fluid dynamics-based method.",

author = "Ming Wang and Xiaochang Leng and Baojie Mao and Rong Zou and Dongdong Lin and Yuhai Gao and Ning Wang and Yuning Lu and Jens Fiehler and Siddiqui, {Adnan H} and Jiong Wu and Jianping Xiang and Shu Wan",

note = "{\textcopyright} 2023 The Authors.",

year = "2023",

month = feb,

doi = "10.1016/j.heliyon.2023.e13527",

language = "English",

volume = "9",

pages = "e13527",

journal = "HELIYON",

issn = "2405-8440",

publisher = "Elsevier BV",

number = "2",

}

RIS

TY - JOUR

T1 - Functional evaluation of intracranial atherosclerotic stenosis by pressure ratio measurements

AU - Wang, Ming

AU - Leng, Xiaochang

AU - Mao, Baojie

AU - Zou, Rong

AU - Lin, Dongdong

AU - Gao, Yuhai

AU - Wang, Ning

AU - Lu, Yuning

AU - Fiehler, Jens

AU - Siddiqui, Adnan H

AU - Wu, Jiong

AU - Xiang, Jianping

AU - Wan, Shu

PY - 2023/2

Y1 - 2023/2

N2 - BACKGROUND: Fractional flow reserve is widely used for the functional evaluation of coronary artery stenosis. Some studies have similarly used the translesional pressure ratio measurements for the functional evaluation of intracranial atherosclerotic stenosis. In this paper, we aimed to investigate the relationship between pressure ratio and cerebral tissue perfusion by MR perfusion imaging and provided a non-invasive method for evaluating the functional significance of intracranial atherosclerotic stenosis.METHODS: A total of 18 consecutive patients with intracranial atherosclerotic stenosis patients including 19 stenotic vessels were recruited. The pressure was measured using a pressure guidewire, the pressure ratio before and after the endovascular intervention was calculated and compared with the severity of diameter stenosis and perfusion-derived MR (the time to maximum tissure residue function (Tmax)). Moreover, the DSA-derived pressure ratio was computed using a novel computational fluid dynamics-based model, termed CFD-PR, and was compared with the actual pressure ratio to assess its diagnostic accuracy.RESULTS: The pressure ratio increased after percutaneous transluminal angioplasty or stenting, while the correlation between pressure ratio and diameter stenosis was not significant. The pressure ratio was negatively correlated with Tmax (r = -0.73, P < 0.01), and a 95% confidence interval for the cutoff value of pressure ratio = 0.67 (95% confidence interval: 0.58-0.76) was suggested. There was a good correlation (mean = 0.02, Spearman's correlation coefficient r = 0.908, P < 0.001) and agreement (limits of agreement: -0.157 to 0.196, P = 0.954) between CFD-PR and the actual pressure ratio.CONCLUSIONS: This exploratory study indicates the pressure ratio may correlate with the perfusion status. The pressure ratio can be calculated through a non-invasive method using a computational fluid dynamics-based method.

AB - BACKGROUND: Fractional flow reserve is widely used for the functional evaluation of coronary artery stenosis. Some studies have similarly used the translesional pressure ratio measurements for the functional evaluation of intracranial atherosclerotic stenosis. In this paper, we aimed to investigate the relationship between pressure ratio and cerebral tissue perfusion by MR perfusion imaging and provided a non-invasive method for evaluating the functional significance of intracranial atherosclerotic stenosis.METHODS: A total of 18 consecutive patients with intracranial atherosclerotic stenosis patients including 19 stenotic vessels were recruited. The pressure was measured using a pressure guidewire, the pressure ratio before and after the endovascular intervention was calculated and compared with the severity of diameter stenosis and perfusion-derived MR (the time to maximum tissure residue function (Tmax)). Moreover, the DSA-derived pressure ratio was computed using a novel computational fluid dynamics-based model, termed CFD-PR, and was compared with the actual pressure ratio to assess its diagnostic accuracy.RESULTS: The pressure ratio increased after percutaneous transluminal angioplasty or stenting, while the correlation between pressure ratio and diameter stenosis was not significant. The pressure ratio was negatively correlated with Tmax (r = -0.73, P < 0.01), and a 95% confidence interval for the cutoff value of pressure ratio = 0.67 (95% confidence interval: 0.58-0.76) was suggested. There was a good correlation (mean = 0.02, Spearman's correlation coefficient r = 0.908, P < 0.001) and agreement (limits of agreement: -0.157 to 0.196, P = 0.954) between CFD-PR and the actual pressure ratio.CONCLUSIONS: This exploratory study indicates the pressure ratio may correlate with the perfusion status. The pressure ratio can be calculated through a non-invasive method using a computational fluid dynamics-based method.

U2 - 10.1016/j.heliyon.2023.e13527

DO - 10.1016/j.heliyon.2023.e13527

M3 - SCORING: Journal article

C2 - 36852079

VL - 9

SP - e13527

JO - HELIYON

JF - HELIYON

SN - 2405-8440

IS - 2

ER -