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Functional Aplasia of the Contralateral A1 Segment Influences Clinical Outcome in Patients with Occlusion of the Distal Internal Carotid Artery

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Functional Aplasia of the Contralateral A1 Segment Influences Clinical Outcome in Patients with Occlusion of the Distal Internal Carotid Artery. / Fischer, Sebastian; Goertz, Lukas; Weyland, Charlotte S; Khanafer, Ali; Maurer, Christoph J; Zimmermann, Hanna; Fischer, Thomas David; Styczen, Hanna; Tan, Benjamin; Alexandrou, Maria; Lobsien, Donald; Lobsien, Elmar; Thormann, Maximilian; Meyer, Lukas; Abdullayev, Nuran; Fiehler, Jens; Mpotsaris, Anastasios; Papanagiotou, Panagiotis; Yeo, Leonard; Deuschl, Cornelius; Liebig, Thomas; Berlis, Ansgar; Henkes, Hans; Möhlenbruch, Markus; Maus, Volker.

In: J CLIN MED, Vol. 11, No. 5, 1293, 26.02.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fischer, S, Goertz, L, Weyland, CS, Khanafer, A, Maurer, CJ, Zimmermann, H, Fischer, TD, Styczen, H, Tan, B, Alexandrou, M, Lobsien, D, Lobsien, E, Thormann, M, Meyer, L, Abdullayev, N, Fiehler, J, Mpotsaris, A, Papanagiotou, P, Yeo, L, Deuschl, C, Liebig, T, Berlis, A, Henkes, H, Möhlenbruch, M & Maus, V 2022, 'Functional Aplasia of the Contralateral A1 Segment Influences Clinical Outcome in Patients with Occlusion of the Distal Internal Carotid Artery', J CLIN MED, vol. 11, no. 5, 1293. https://doi.org/10.3390/jcm11051293

APA

Fischer, S., Goertz, L., Weyland, C. S., Khanafer, A., Maurer, C. J., Zimmermann, H., Fischer, T. D., Styczen, H., Tan, B., Alexandrou, M., Lobsien, D., Lobsien, E., Thormann, M., Meyer, L., Abdullayev, N., Fiehler, J., Mpotsaris, A., Papanagiotou, P., Yeo, L., ... Maus, V. (2022). Functional Aplasia of the Contralateral A1 Segment Influences Clinical Outcome in Patients with Occlusion of the Distal Internal Carotid Artery. J CLIN MED, 11(5), [1293]. https://doi.org/10.3390/jcm11051293

Vancouver

Fischer S, Goertz L, Weyland CS, Khanafer A, Maurer CJ, Zimmermann H et al. Functional Aplasia of the Contralateral A1 Segment Influences Clinical Outcome in Patients with Occlusion of the Distal Internal Carotid Artery. J CLIN MED. 2022 Feb 26;11(5). 1293. https://doi.org/10.3390/jcm11051293

Bibtex

@article{1a7e17f82b524a72a9348c06afcaf6d7,
title = "Functional Aplasia of the Contralateral A1 Segment Influences Clinical Outcome in Patients with Occlusion of the Distal Internal Carotid Artery",
abstract = "Background: The importance of an A1 aplasia remains unclear in stroke patients. In this work, we analyze the impact of an A1 aplasia contralateral to an acute occlusion of the distal internal carotid artery (ICA) on clinical outcomes. Methods: We conducted a retrospective study of consecutive stroke patients treated with mechanical thrombectomy at 12 tertiary care centers between January 2015 and February 2021 due to an occlusion of the distal ICA. Functional A1 aplasia was defined as the absence of A1 or hypoplastic A1 (>50% reduction to the contralateral site). Functional independence was measured by the modified Rankin Scale (mRS ≤ 2). Results: In total, 81 out of 1068 (8%) patients had functional A1 aplasia contralateral to distal ICA occlusion. Patients with functional contralateral A1 aplasia were more severely affected on admission (median NIHSS 18, IQR 15−23 vs. 17, IQR 13−21; aOR: 0.672, 95% CI: 0.448−1.007, p = 0.054) and post-interventional ischemic damage was larger (median ASPECTS 5, IQR 1−7, vs. 6, IQR 3−8; aOR: 1.817, 95% CI: 1.184−2.789, p = 0.006). Infarction occurred more often within the ipsilateral ACA territory (20/76, 26% vs. 110/961, 11%; aOR: 2.482, 95% CI: 1.389−4.437, p = 0.002) and both ACA territories (8/76, 11% vs. 5/961, 1%; aOR: 17.968, 95% CI: 4.979−64.847, p ≤ 0.001). Functional contralateral A1 aplasia was associated with a lower rate of functional independence at discharge (6/81, 8% vs. 194/965, 20%; aOR: 2.579, 95% CI: 1.086−6.122, p = 0.032) and after 90 days (5/55, 9% vs. 170/723, 24%; aOR: 2.664, 95% CI: 1.031−6.883, p = 0.043). Conclusions: A functional A1 aplasia contralateral to a distal ICA occlusion is associated with a poorer clinical outcome.",
author = "Sebastian Fischer and Lukas Goertz and Weyland, {Charlotte S} and Ali Khanafer and Maurer, {Christoph J} and Hanna Zimmermann and Fischer, {Thomas David} and Hanna Styczen and Benjamin Tan and Maria Alexandrou and Donald Lobsien and Elmar Lobsien and Maximilian Thormann and Lukas Meyer and Nuran Abdullayev and Jens Fiehler and Anastasios Mpotsaris and Panagiotis Papanagiotou and Leonard Yeo and Cornelius Deuschl and Thomas Liebig and Ansgar Berlis and Hans Henkes and Markus M{\"o}hlenbruch and Volker Maus",
year = "2022",
month = feb,
day = "26",
doi = "10.3390/jcm11051293",
language = "English",
volume = "11",
journal = "J CLIN MED",
issn = "2077-0383",
publisher = "MDPI AG",
number = "5",

}

RIS

TY - JOUR

T1 - Functional Aplasia of the Contralateral A1 Segment Influences Clinical Outcome in Patients with Occlusion of the Distal Internal Carotid Artery

AU - Fischer, Sebastian

AU - Goertz, Lukas

AU - Weyland, Charlotte S

AU - Khanafer, Ali

AU - Maurer, Christoph J

AU - Zimmermann, Hanna

AU - Fischer, Thomas David

AU - Styczen, Hanna

AU - Tan, Benjamin

AU - Alexandrou, Maria

AU - Lobsien, Donald

AU - Lobsien, Elmar

AU - Thormann, Maximilian

AU - Meyer, Lukas

AU - Abdullayev, Nuran

AU - Fiehler, Jens

AU - Mpotsaris, Anastasios

AU - Papanagiotou, Panagiotis

AU - Yeo, Leonard

AU - Deuschl, Cornelius

AU - Liebig, Thomas

AU - Berlis, Ansgar

AU - Henkes, Hans

AU - Möhlenbruch, Markus

AU - Maus, Volker

PY - 2022/2/26

Y1 - 2022/2/26

N2 - Background: The importance of an A1 aplasia remains unclear in stroke patients. In this work, we analyze the impact of an A1 aplasia contralateral to an acute occlusion of the distal internal carotid artery (ICA) on clinical outcomes. Methods: We conducted a retrospective study of consecutive stroke patients treated with mechanical thrombectomy at 12 tertiary care centers between January 2015 and February 2021 due to an occlusion of the distal ICA. Functional A1 aplasia was defined as the absence of A1 or hypoplastic A1 (>50% reduction to the contralateral site). Functional independence was measured by the modified Rankin Scale (mRS ≤ 2). Results: In total, 81 out of 1068 (8%) patients had functional A1 aplasia contralateral to distal ICA occlusion. Patients with functional contralateral A1 aplasia were more severely affected on admission (median NIHSS 18, IQR 15−23 vs. 17, IQR 13−21; aOR: 0.672, 95% CI: 0.448−1.007, p = 0.054) and post-interventional ischemic damage was larger (median ASPECTS 5, IQR 1−7, vs. 6, IQR 3−8; aOR: 1.817, 95% CI: 1.184−2.789, p = 0.006). Infarction occurred more often within the ipsilateral ACA territory (20/76, 26% vs. 110/961, 11%; aOR: 2.482, 95% CI: 1.389−4.437, p = 0.002) and both ACA territories (8/76, 11% vs. 5/961, 1%; aOR: 17.968, 95% CI: 4.979−64.847, p ≤ 0.001). Functional contralateral A1 aplasia was associated with a lower rate of functional independence at discharge (6/81, 8% vs. 194/965, 20%; aOR: 2.579, 95% CI: 1.086−6.122, p = 0.032) and after 90 days (5/55, 9% vs. 170/723, 24%; aOR: 2.664, 95% CI: 1.031−6.883, p = 0.043). Conclusions: A functional A1 aplasia contralateral to a distal ICA occlusion is associated with a poorer clinical outcome.

AB - Background: The importance of an A1 aplasia remains unclear in stroke patients. In this work, we analyze the impact of an A1 aplasia contralateral to an acute occlusion of the distal internal carotid artery (ICA) on clinical outcomes. Methods: We conducted a retrospective study of consecutive stroke patients treated with mechanical thrombectomy at 12 tertiary care centers between January 2015 and February 2021 due to an occlusion of the distal ICA. Functional A1 aplasia was defined as the absence of A1 or hypoplastic A1 (>50% reduction to the contralateral site). Functional independence was measured by the modified Rankin Scale (mRS ≤ 2). Results: In total, 81 out of 1068 (8%) patients had functional A1 aplasia contralateral to distal ICA occlusion. Patients with functional contralateral A1 aplasia were more severely affected on admission (median NIHSS 18, IQR 15−23 vs. 17, IQR 13−21; aOR: 0.672, 95% CI: 0.448−1.007, p = 0.054) and post-interventional ischemic damage was larger (median ASPECTS 5, IQR 1−7, vs. 6, IQR 3−8; aOR: 1.817, 95% CI: 1.184−2.789, p = 0.006). Infarction occurred more often within the ipsilateral ACA territory (20/76, 26% vs. 110/961, 11%; aOR: 2.482, 95% CI: 1.389−4.437, p = 0.002) and both ACA territories (8/76, 11% vs. 5/961, 1%; aOR: 17.968, 95% CI: 4.979−64.847, p ≤ 0.001). Functional contralateral A1 aplasia was associated with a lower rate of functional independence at discharge (6/81, 8% vs. 194/965, 20%; aOR: 2.579, 95% CI: 1.086−6.122, p = 0.032) and after 90 days (5/55, 9% vs. 170/723, 24%; aOR: 2.664, 95% CI: 1.031−6.883, p = 0.043). Conclusions: A functional A1 aplasia contralateral to a distal ICA occlusion is associated with a poorer clinical outcome.

U2 - 10.3390/jcm11051293

DO - 10.3390/jcm11051293

M3 - SCORING: Journal article

C2 - 35268383

VL - 11

JO - J CLIN MED

JF - J CLIN MED

SN - 2077-0383

IS - 5

M1 - 1293

ER -