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Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity

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Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity. / Lock, Johan Friso; Malinowski, Maciej; Seehofer, Daniel; Hoppe, Steffi; Röhl, Rhea Isabel; Niehues, Stefan Markus; Neuhaus, Peter; Stockmann, Martin.

In: LANGENBECK ARCH SURG, Vol. 397, No. 8, 12.2012, p. 1297-304.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lock, JF, Malinowski, M, Seehofer, D, Hoppe, S, Röhl, RI, Niehues, SM, Neuhaus, P & Stockmann, M 2012, 'Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity', LANGENBECK ARCH SURG, vol. 397, no. 8, pp. 1297-304. https://doi.org/10.1007/s00423-012-0972-2

APA

Lock, J. F., Malinowski, M., Seehofer, D., Hoppe, S., Röhl, R. I., Niehues, S. M., Neuhaus, P., & Stockmann, M. (2012). Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity. LANGENBECK ARCH SURG, 397(8), 1297-304. https://doi.org/10.1007/s00423-012-0972-2

Vancouver

Lock JF, Malinowski M, Seehofer D, Hoppe S, Röhl RI, Niehues SM et al. Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity. LANGENBECK ARCH SURG. 2012 Dec;397(8):1297-304. https://doi.org/10.1007/s00423-012-0972-2

Bibtex

@article{32070dc6f575463889a3348c020e70d5,
title = "Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity",
abstract = "BACKGROUND: The regenerative capacity of the liver is an essential pre-condition for the successful application of partial hepatectomy. However, the actual kinetics of functional recovery remains unspecified and no adequate tool for its clinical monitoring has yet been available.METHODS: Eighty-five patients receiving major hepatectomy were investigated from the preoperative evaluation until 12 weeks after surgery. Liver function was determined by the LiMAx test for the enzymatic capacity of cytochrome P450 1A2. Liver volume was determined by volumetric analysis of repeated computer tomography scans. Functional and volume recovery were compared during follow-up.RESULTS: Major hepatectomy decreased liver function capacity to 35.7 ± 13.8% of preoperative function. It was shown that functional recovery already reaches 77.2 ± 33.5% of preoperative values within 10 days. The actual kinetics were dependent from the type and extent of hepatectomy. Complete functional restoration was achieved within 12 weeks, while liver volume still remained at 73.2 ± 14.8% of preoperative. A constant but interindividually variable correlation between function and volume was observed at all points in time.CONCLUSION: Partial hepatectomy leads to fast and complete functional recovery, while volume recovery is delayed and remains often incomplete. The functional recovery is mainly influenced by the preoperative liver function, the residual liver volume, and by obesity.",
keywords = "Female, Hepatectomy, Humans, Liver, Liver Function Tests, Liver Neoplasms, Liver Regeneration, Male, Middle Aged, Obesity, Organ Size",
author = "Lock, {Johan Friso} and Maciej Malinowski and Daniel Seehofer and Steffi Hoppe and R{\"o}hl, {Rhea Isabel} and Niehues, {Stefan Markus} and Peter Neuhaus and Martin Stockmann",
year = "2012",
month = dec,
doi = "10.1007/s00423-012-0972-2",
language = "English",
volume = "397",
pages = "1297--304",
journal = "LANGENBECK ARCH SURG",
issn = "1435-2443",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity

AU - Lock, Johan Friso

AU - Malinowski, Maciej

AU - Seehofer, Daniel

AU - Hoppe, Steffi

AU - Röhl, Rhea Isabel

AU - Niehues, Stefan Markus

AU - Neuhaus, Peter

AU - Stockmann, Martin

PY - 2012/12

Y1 - 2012/12

N2 - BACKGROUND: The regenerative capacity of the liver is an essential pre-condition for the successful application of partial hepatectomy. However, the actual kinetics of functional recovery remains unspecified and no adequate tool for its clinical monitoring has yet been available.METHODS: Eighty-five patients receiving major hepatectomy were investigated from the preoperative evaluation until 12 weeks after surgery. Liver function was determined by the LiMAx test for the enzymatic capacity of cytochrome P450 1A2. Liver volume was determined by volumetric analysis of repeated computer tomography scans. Functional and volume recovery were compared during follow-up.RESULTS: Major hepatectomy decreased liver function capacity to 35.7 ± 13.8% of preoperative function. It was shown that functional recovery already reaches 77.2 ± 33.5% of preoperative values within 10 days. The actual kinetics were dependent from the type and extent of hepatectomy. Complete functional restoration was achieved within 12 weeks, while liver volume still remained at 73.2 ± 14.8% of preoperative. A constant but interindividually variable correlation between function and volume was observed at all points in time.CONCLUSION: Partial hepatectomy leads to fast and complete functional recovery, while volume recovery is delayed and remains often incomplete. The functional recovery is mainly influenced by the preoperative liver function, the residual liver volume, and by obesity.

AB - BACKGROUND: The regenerative capacity of the liver is an essential pre-condition for the successful application of partial hepatectomy. However, the actual kinetics of functional recovery remains unspecified and no adequate tool for its clinical monitoring has yet been available.METHODS: Eighty-five patients receiving major hepatectomy were investigated from the preoperative evaluation until 12 weeks after surgery. Liver function was determined by the LiMAx test for the enzymatic capacity of cytochrome P450 1A2. Liver volume was determined by volumetric analysis of repeated computer tomography scans. Functional and volume recovery were compared during follow-up.RESULTS: Major hepatectomy decreased liver function capacity to 35.7 ± 13.8% of preoperative function. It was shown that functional recovery already reaches 77.2 ± 33.5% of preoperative values within 10 days. The actual kinetics were dependent from the type and extent of hepatectomy. Complete functional restoration was achieved within 12 weeks, while liver volume still remained at 73.2 ± 14.8% of preoperative. A constant but interindividually variable correlation between function and volume was observed at all points in time.CONCLUSION: Partial hepatectomy leads to fast and complete functional recovery, while volume recovery is delayed and remains often incomplete. The functional recovery is mainly influenced by the preoperative liver function, the residual liver volume, and by obesity.

KW - Female

KW - Hepatectomy

KW - Humans

KW - Liver

KW - Liver Function Tests

KW - Liver Neoplasms

KW - Liver Regeneration

KW - Male

KW - Middle Aged

KW - Obesity

KW - Organ Size

U2 - 10.1007/s00423-012-0972-2

DO - 10.1007/s00423-012-0972-2

M3 - SCORING: Journal article

C2 - 22729717

VL - 397

SP - 1297

EP - 1304

JO - LANGENBECK ARCH SURG

JF - LANGENBECK ARCH SURG

SN - 1435-2443

IS - 8

ER -