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Fuhrman grade [corrected] has no added value in prediction of mortality after partial or [corrected] radical nephrectomy for chromophobe renal cell carcinoma patients

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Fuhrman grade [corrected] has no added value in prediction of mortality after partial or [corrected] radical nephrectomy for chromophobe renal cell carcinoma patients. / Meskawi, Malek; Sun, Maxine; Ismail, Salima; Bianchi, Marco; Hansen, Jens; Tian, Zhe; Hanna, Nawar; Trinh, Quoc-Dien; Graefen, Markus; Montorsi, Francesco; Perrotte, Paul; Karakiewicz, Pierre I.

In: MODERN PATHOL, Vol. 26, No. 8, 01.08.2013, p. 1144-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Meskawi, M, Sun, M, Ismail, S, Bianchi, M, Hansen, J, Tian, Z, Hanna, N, Trinh, Q-D, Graefen, M, Montorsi, F, Perrotte, P & Karakiewicz, PI 2013, 'Fuhrman grade [corrected] has no added value in prediction of mortality after partial or [corrected] radical nephrectomy for chromophobe renal cell carcinoma patients', MODERN PATHOL, vol. 26, no. 8, pp. 1144-9. https://doi.org/10.1038/modpathol.2012.230

APA

Meskawi, M., Sun, M., Ismail, S., Bianchi, M., Hansen, J., Tian, Z., Hanna, N., Trinh, Q-D., Graefen, M., Montorsi, F., Perrotte, P., & Karakiewicz, P. I. (2013). Fuhrman grade [corrected] has no added value in prediction of mortality after partial or [corrected] radical nephrectomy for chromophobe renal cell carcinoma patients. MODERN PATHOL, 26(8), 1144-9. https://doi.org/10.1038/modpathol.2012.230

Vancouver

Meskawi M, Sun M, Ismail S, Bianchi M, Hansen J, Tian Z et al. Fuhrman grade [corrected] has no added value in prediction of mortality after partial or [corrected] radical nephrectomy for chromophobe renal cell carcinoma patients. MODERN PATHOL. 2013 Aug 1;26(8):1144-9. https://doi.org/10.1038/modpathol.2012.230

Bibtex

@article{fc012f00e5fc49e5ac2bcbe509ddf354,
title = "Fuhrman grade [corrected] has no added value in prediction of mortality after partial or [corrected] radical nephrectomy for chromophobe renal cell carcinoma patients",
abstract = "Our objective was to test whether Fuhrman grade [corrected] (FG) is applicable in the context of chromophobe renal cell carcinoma patients treated with partial and radical nephrectomy. Patients (n=1862) with chromophobe renal cell carcinoma treated with partial and radical nephrectomy were identified within the Surveillance, Epidemiology, and End Results (1988-2008). Univariable and multivariable Cox regression analyses were fitted to predict cancer-specific mortality. Discriminant properties were assessed for the conventional four-tiered FG scheme. Additionally, discrimination of the three-tiered FG scheme (1-2 vs 3 vs 4) and the two-tiered FG scheme (1-2 vs 3-4) was also assessed. The statistical significance of the differences in accuracy estimates was compared using the Mantel-Haenszel test. A total of 65 of the 1862 died of the disease. The overall 5-year cancer-specific mortality-free survival rate was 94.8% (95% confidence interval: 93.5-96.2). In univariable analyses, none of the FG strata were significantly associated with cancer-specific mortality. Furthermore, FG was less informative (63%) than tumor size (72%) and tumor stage (69%), using measures of discrimination in univariable analyses. After accounting for all covariates, prediction of 5-year cancer-specific mortality was 79.0% vs 80.3% accurate, respectively, with vs without the consideration of FG (P=0.01). Similar discrimination estimates were obtained for the modified three-tiered FG scheme (78.5%; P=0.009) and the modified two-tiered FG scheme (79.5%; P=0.02). In conclusion, FG is not an informative predictor of prognosis, defined as cancer-specific mortality, after partial and radical nephrectomy for chromophobe renal cell carcinoma patients.",
keywords = "Aged, Carcinoma, Renal Cell, Female, Humans, Kidney Neoplasms, Male, Middle Aged, Neoplasm Grading, Nephrectomy, Prognosis, Proportional Hazards Models, SEER Program",
author = "Malek Meskawi and Maxine Sun and Salima Ismail and Marco Bianchi and Jens Hansen and Zhe Tian and Nawar Hanna and Quoc-Dien Trinh and Markus Graefen and Francesco Montorsi and Paul Perrotte and Karakiewicz, {Pierre I}",
year = "2013",
month = aug,
day = "1",
doi = "10.1038/modpathol.2012.230",
language = "English",
volume = "26",
pages = "1144--9",
journal = "MODERN PATHOL",
issn = "0893-3952",
publisher = "NATURE PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - Fuhrman grade [corrected] has no added value in prediction of mortality after partial or [corrected] radical nephrectomy for chromophobe renal cell carcinoma patients

AU - Meskawi, Malek

AU - Sun, Maxine

AU - Ismail, Salima

AU - Bianchi, Marco

AU - Hansen, Jens

AU - Tian, Zhe

AU - Hanna, Nawar

AU - Trinh, Quoc-Dien

AU - Graefen, Markus

AU - Montorsi, Francesco

AU - Perrotte, Paul

AU - Karakiewicz, Pierre I

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Our objective was to test whether Fuhrman grade [corrected] (FG) is applicable in the context of chromophobe renal cell carcinoma patients treated with partial and radical nephrectomy. Patients (n=1862) with chromophobe renal cell carcinoma treated with partial and radical nephrectomy were identified within the Surveillance, Epidemiology, and End Results (1988-2008). Univariable and multivariable Cox regression analyses were fitted to predict cancer-specific mortality. Discriminant properties were assessed for the conventional four-tiered FG scheme. Additionally, discrimination of the three-tiered FG scheme (1-2 vs 3 vs 4) and the two-tiered FG scheme (1-2 vs 3-4) was also assessed. The statistical significance of the differences in accuracy estimates was compared using the Mantel-Haenszel test. A total of 65 of the 1862 died of the disease. The overall 5-year cancer-specific mortality-free survival rate was 94.8% (95% confidence interval: 93.5-96.2). In univariable analyses, none of the FG strata were significantly associated with cancer-specific mortality. Furthermore, FG was less informative (63%) than tumor size (72%) and tumor stage (69%), using measures of discrimination in univariable analyses. After accounting for all covariates, prediction of 5-year cancer-specific mortality was 79.0% vs 80.3% accurate, respectively, with vs without the consideration of FG (P=0.01). Similar discrimination estimates were obtained for the modified three-tiered FG scheme (78.5%; P=0.009) and the modified two-tiered FG scheme (79.5%; P=0.02). In conclusion, FG is not an informative predictor of prognosis, defined as cancer-specific mortality, after partial and radical nephrectomy for chromophobe renal cell carcinoma patients.

AB - Our objective was to test whether Fuhrman grade [corrected] (FG) is applicable in the context of chromophobe renal cell carcinoma patients treated with partial and radical nephrectomy. Patients (n=1862) with chromophobe renal cell carcinoma treated with partial and radical nephrectomy were identified within the Surveillance, Epidemiology, and End Results (1988-2008). Univariable and multivariable Cox regression analyses were fitted to predict cancer-specific mortality. Discriminant properties were assessed for the conventional four-tiered FG scheme. Additionally, discrimination of the three-tiered FG scheme (1-2 vs 3 vs 4) and the two-tiered FG scheme (1-2 vs 3-4) was also assessed. The statistical significance of the differences in accuracy estimates was compared using the Mantel-Haenszel test. A total of 65 of the 1862 died of the disease. The overall 5-year cancer-specific mortality-free survival rate was 94.8% (95% confidence interval: 93.5-96.2). In univariable analyses, none of the FG strata were significantly associated with cancer-specific mortality. Furthermore, FG was less informative (63%) than tumor size (72%) and tumor stage (69%), using measures of discrimination in univariable analyses. After accounting for all covariates, prediction of 5-year cancer-specific mortality was 79.0% vs 80.3% accurate, respectively, with vs without the consideration of FG (P=0.01). Similar discrimination estimates were obtained for the modified three-tiered FG scheme (78.5%; P=0.009) and the modified two-tiered FG scheme (79.5%; P=0.02). In conclusion, FG is not an informative predictor of prognosis, defined as cancer-specific mortality, after partial and radical nephrectomy for chromophobe renal cell carcinoma patients.

KW - Aged

KW - Carcinoma, Renal Cell

KW - Female

KW - Humans

KW - Kidney Neoplasms

KW - Male

KW - Middle Aged

KW - Neoplasm Grading

KW - Nephrectomy

KW - Prognosis

KW - Proportional Hazards Models

KW - SEER Program

U2 - 10.1038/modpathol.2012.230

DO - 10.1038/modpathol.2012.230

M3 - SCORING: Journal article

C2 - 23370773

VL - 26

SP - 1144

EP - 1149

JO - MODERN PATHOL

JF - MODERN PATHOL

SN - 0893-3952

IS - 8

ER -