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FTO, obesity and the adolescent brain

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FTO, obesity and the adolescent brain. / Melka, Melkaye G; Gillis, Jesse; Bernard, Manon; Abrahamowicz, Michal; Chakravarty, M Mallar; Leonard, Gabriel T; Perron, Michel; Richer, Louis; Veillette, Suzanne; Banaschewski, Tobias; Barker, Gareth J; Büchel, Christian; Conrod, Patricia; Flor, Herta; Heinz, Andreas; Garavan, Hugh; Brühl, Rüdiger; Mann, Karl; Artiges, Eric; Lourdusamy, Anbarasu; Lathrop, Mark; Loth, Eva; Schwartz, Yannick; Frouin, Vincent; Rietschel, Marcella; Smolka, Michael N; Ströhle, Andreas; Gallinat, Jürgen; Struve, Maren; Lattka, Eva; Waldenberger, Melanie; Schumann, Gunter; Pavlidis, Paul; Gaudet, Daniel; Paus, Tomás; Pausova, Zdenka.

In: HUM MOL GENET, Vol. 22, No. 5, 01.03.2013, p. 1050-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Melka, MG, Gillis, J, Bernard, M, Abrahamowicz, M, Chakravarty, MM, Leonard, GT, Perron, M, Richer, L, Veillette, S, Banaschewski, T, Barker, GJ, Büchel, C, Conrod, P, Flor, H, Heinz, A, Garavan, H, Brühl, R, Mann, K, Artiges, E, Lourdusamy, A, Lathrop, M, Loth, E, Schwartz, Y, Frouin, V, Rietschel, M, Smolka, MN, Ströhle, A, Gallinat, J, Struve, M, Lattka, E, Waldenberger, M, Schumann, G, Pavlidis, P, Gaudet, D, Paus, T & Pausova, Z 2013, 'FTO, obesity and the adolescent brain', HUM MOL GENET, vol. 22, no. 5, pp. 1050-8. https://doi.org/10.1093/hmg/dds504

APA

Melka, M. G., Gillis, J., Bernard, M., Abrahamowicz, M., Chakravarty, M. M., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Banaschewski, T., Barker, G. J., Büchel, C., Conrod, P., Flor, H., Heinz, A., Garavan, H., Brühl, R., Mann, K., Artiges, E., ... Pausova, Z. (2013). FTO, obesity and the adolescent brain. HUM MOL GENET, 22(5), 1050-8. https://doi.org/10.1093/hmg/dds504

Vancouver

Melka MG, Gillis J, Bernard M, Abrahamowicz M, Chakravarty MM, Leonard GT et al. FTO, obesity and the adolescent brain. HUM MOL GENET. 2013 Mar 1;22(5):1050-8. https://doi.org/10.1093/hmg/dds504

Bibtex

@article{d80861c4f1254649a75b726e68383038,
title = "FTO, obesity and the adolescent brain",
abstract = "Genetic variations in fat mass- and obesity (FTO)-associated gene, a well-replicated gene locus of obesity, appear to be associated also with reduced regional brain volumes in elderly. Here, we examined whether FTO is associated with total brain volume in adolescence, thus exploring possible developmental effects of FTO. We studied a population-based sample of 598 adolescents recruited from the French Canadian founder population in whom we measured brain volume by magnetic resonance imaging. Total fat mass was assessed with bioimpedance and body mass index was determined with anthropometry. Genotype-phenotype associations were tested with Merlin under an additive model. We found that the G allele of FTO (rs9930333) was associated with higher total body fat [TBF (P = 0.002) and lower brain volume (P = 0.005)]. The same allele was also associated with higher lean body mass (P = 0.03) and no difference in height (P = 0.99). Principal component analysis identified a shared inverse variance between the brain volume and TBF, which was associated with FTO at P = 5.5 × 10(-6). These results were replicated in two independent samples of 413 and 718 adolescents, and in a meta-analysis of all three samples (n = 1729 adolescents), FTO was associated with this shared inverse variance at P = 1.3 × 10(-9). Co-expression networks analysis supported the possibility that the underlying FTO effects may occur during embryogenesis. In conclusion, FTO is associated with shared inverse variance between body adiposity and brain volume, suggesting that this gene may exert inverse effects on adipose and brain tissues. Given the completion of the overall brain growth in early childhood, these effects may have their origins during early development.",
keywords = "Adipose Tissue, Adiposity, Adolescent, Anthropometry, Body Mass Index, Brain, Female, Genetic Predisposition to Disease, Humans, Male, Obesity, Proteins",
author = "Melka, {Melkaye G} and Jesse Gillis and Manon Bernard and Michal Abrahamowicz and Chakravarty, {M Mallar} and Leonard, {Gabriel T} and Michel Perron and Louis Richer and Suzanne Veillette and Tobias Banaschewski and Barker, {Gareth J} and Christian B{\"u}chel and Patricia Conrod and Herta Flor and Andreas Heinz and Hugh Garavan and R{\"u}diger Br{\"u}hl and Karl Mann and Eric Artiges and Anbarasu Lourdusamy and Mark Lathrop and Eva Loth and Yannick Schwartz and Vincent Frouin and Marcella Rietschel and Smolka, {Michael N} and Andreas Str{\"o}hle and J{\"u}rgen Gallinat and Maren Struve and Eva Lattka and Melanie Waldenberger and Gunter Schumann and Paul Pavlidis and Daniel Gaudet and Tom{\'a}s Paus and Zdenka Pausova",
year = "2013",
month = mar,
day = "1",
doi = "10.1093/hmg/dds504",
language = "English",
volume = "22",
pages = "1050--8",
journal = "HUM MOL GENET",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - FTO, obesity and the adolescent brain

AU - Melka, Melkaye G

AU - Gillis, Jesse

AU - Bernard, Manon

AU - Abrahamowicz, Michal

AU - Chakravarty, M Mallar

AU - Leonard, Gabriel T

AU - Perron, Michel

AU - Richer, Louis

AU - Veillette, Suzanne

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Büchel, Christian

AU - Conrod, Patricia

AU - Flor, Herta

AU - Heinz, Andreas

AU - Garavan, Hugh

AU - Brühl, Rüdiger

AU - Mann, Karl

AU - Artiges, Eric

AU - Lourdusamy, Anbarasu

AU - Lathrop, Mark

AU - Loth, Eva

AU - Schwartz, Yannick

AU - Frouin, Vincent

AU - Rietschel, Marcella

AU - Smolka, Michael N

AU - Ströhle, Andreas

AU - Gallinat, Jürgen

AU - Struve, Maren

AU - Lattka, Eva

AU - Waldenberger, Melanie

AU - Schumann, Gunter

AU - Pavlidis, Paul

AU - Gaudet, Daniel

AU - Paus, Tomás

AU - Pausova, Zdenka

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Genetic variations in fat mass- and obesity (FTO)-associated gene, a well-replicated gene locus of obesity, appear to be associated also with reduced regional brain volumes in elderly. Here, we examined whether FTO is associated with total brain volume in adolescence, thus exploring possible developmental effects of FTO. We studied a population-based sample of 598 adolescents recruited from the French Canadian founder population in whom we measured brain volume by magnetic resonance imaging. Total fat mass was assessed with bioimpedance and body mass index was determined with anthropometry. Genotype-phenotype associations were tested with Merlin under an additive model. We found that the G allele of FTO (rs9930333) was associated with higher total body fat [TBF (P = 0.002) and lower brain volume (P = 0.005)]. The same allele was also associated with higher lean body mass (P = 0.03) and no difference in height (P = 0.99). Principal component analysis identified a shared inverse variance between the brain volume and TBF, which was associated with FTO at P = 5.5 × 10(-6). These results were replicated in two independent samples of 413 and 718 adolescents, and in a meta-analysis of all three samples (n = 1729 adolescents), FTO was associated with this shared inverse variance at P = 1.3 × 10(-9). Co-expression networks analysis supported the possibility that the underlying FTO effects may occur during embryogenesis. In conclusion, FTO is associated with shared inverse variance between body adiposity and brain volume, suggesting that this gene may exert inverse effects on adipose and brain tissues. Given the completion of the overall brain growth in early childhood, these effects may have their origins during early development.

AB - Genetic variations in fat mass- and obesity (FTO)-associated gene, a well-replicated gene locus of obesity, appear to be associated also with reduced regional brain volumes in elderly. Here, we examined whether FTO is associated with total brain volume in adolescence, thus exploring possible developmental effects of FTO. We studied a population-based sample of 598 adolescents recruited from the French Canadian founder population in whom we measured brain volume by magnetic resonance imaging. Total fat mass was assessed with bioimpedance and body mass index was determined with anthropometry. Genotype-phenotype associations were tested with Merlin under an additive model. We found that the G allele of FTO (rs9930333) was associated with higher total body fat [TBF (P = 0.002) and lower brain volume (P = 0.005)]. The same allele was also associated with higher lean body mass (P = 0.03) and no difference in height (P = 0.99). Principal component analysis identified a shared inverse variance between the brain volume and TBF, which was associated with FTO at P = 5.5 × 10(-6). These results were replicated in two independent samples of 413 and 718 adolescents, and in a meta-analysis of all three samples (n = 1729 adolescents), FTO was associated with this shared inverse variance at P = 1.3 × 10(-9). Co-expression networks analysis supported the possibility that the underlying FTO effects may occur during embryogenesis. In conclusion, FTO is associated with shared inverse variance between body adiposity and brain volume, suggesting that this gene may exert inverse effects on adipose and brain tissues. Given the completion of the overall brain growth in early childhood, these effects may have their origins during early development.

KW - Adipose Tissue

KW - Adiposity

KW - Adolescent

KW - Anthropometry

KW - Body Mass Index

KW - Brain

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Obesity

KW - Proteins

U2 - 10.1093/hmg/dds504

DO - 10.1093/hmg/dds504

M3 - SCORING: Journal article

C2 - 23201753

VL - 22

SP - 1050

EP - 1058

JO - HUM MOL GENET

JF - HUM MOL GENET

SN - 0964-6906

IS - 5

ER -