From the genome to the proteome--biomarkers in colorectal cancer
Standard
From the genome to the proteome--biomarkers in colorectal cancer. / Habermann, Jens K; Bader, Franz G; Franke, Christian; Zimmermann, Kaja; Gemoll, Timo; Fritzsche, Britta; Ried, Thomas; Auer, Gert; Bruch, Hans-Peter; Roblick, Uwe J.
In: LANGENBECK ARCH SURG, Vol. 393, No. 1, 01.2008, p. 93-104.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - From the genome to the proteome--biomarkers in colorectal cancer
AU - Habermann, Jens K
AU - Bader, Franz G
AU - Franke, Christian
AU - Zimmermann, Kaja
AU - Gemoll, Timo
AU - Fritzsche, Britta
AU - Ried, Thomas
AU - Auer, Gert
AU - Bruch, Hans-Peter
AU - Roblick, Uwe J
PY - 2008/1
Y1 - 2008/1
N2 - BACKGROUND AND AIMS: Colorectal cancer is the second leading cause of cancer-related death. Current clinical practice in colorectal cancer screening (fecal occult blood test, FOBT; colonoscopy) has contributed to a reduction of mortality. However, despite these screening programs, about 70% of carcinomas are detected at advanced tumor stages (UICC III/IV) presenting poor patient prognosis. Thus, innovative tools and methodologies for early cancer detection can directly result in improving patient survival rates.PATIENTS/METHODS: Biomedical research has advanced rapidly in recent years with the availability of technologies such as global gene and protein expression profiling. Comprehensive tumor profiling has become a field of intensive research aiming at identifying biomarkers relevant for improved diagnostics and therapeutics.RESULTS: In this paper, we report a comprehensive review of genomic, transcriptomic, and proteomic approaches for biomarker identification in tissue and blood with a main emphasis on two-dimensional gel-electrophoresis (2-DE) and mass spectrometry analyses.CONCLUSION: Proteomics-based technologies enable to distinguish the healthy patient from the tumor patient with high sensitivity and specificity and could greatly improve common classification systems and diagnostics. However, this progress has not yet been transferred from bench to bedside but could open the door to a more accurate and target specific personalized medicine with improved patient survival.
AB - BACKGROUND AND AIMS: Colorectal cancer is the second leading cause of cancer-related death. Current clinical practice in colorectal cancer screening (fecal occult blood test, FOBT; colonoscopy) has contributed to a reduction of mortality. However, despite these screening programs, about 70% of carcinomas are detected at advanced tumor stages (UICC III/IV) presenting poor patient prognosis. Thus, innovative tools and methodologies for early cancer detection can directly result in improving patient survival rates.PATIENTS/METHODS: Biomedical research has advanced rapidly in recent years with the availability of technologies such as global gene and protein expression profiling. Comprehensive tumor profiling has become a field of intensive research aiming at identifying biomarkers relevant for improved diagnostics and therapeutics.RESULTS: In this paper, we report a comprehensive review of genomic, transcriptomic, and proteomic approaches for biomarker identification in tissue and blood with a main emphasis on two-dimensional gel-electrophoresis (2-DE) and mass spectrometry analyses.CONCLUSION: Proteomics-based technologies enable to distinguish the healthy patient from the tumor patient with high sensitivity and specificity and could greatly improve common classification systems and diagnostics. However, this progress has not yet been transferred from bench to bedside but could open the door to a more accurate and target specific personalized medicine with improved patient survival.
KW - Aneuploidy
KW - Biomarkers, Tumor
KW - Colorectal Neoplasms
KW - Electrophoresis, Gel, Two-Dimensional
KW - Gene Expression Profiling
KW - Genetic Markers
KW - Genome
KW - Humans
KW - Mass Spectrometry
KW - Neoplasm Staging
KW - Predictive Value of Tests
KW - Protein Array Analysis
KW - Proteome
KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
KW - Journal Article
KW - Review
U2 - 10.1007/s00423-007-0230-1
DO - 10.1007/s00423-007-0230-1
M3 - SCORING: Journal article
C2 - 17938952
VL - 393
SP - 93
EP - 104
JO - LANGENBECK ARCH SURG
JF - LANGENBECK ARCH SURG
SN - 1435-2443
IS - 1
ER -