From Shortage to Surge: A Developmental Switch in Hippocampal-Prefrontal Coupling in a Gene-Environment Model of Neuropsychiatric Disorders
Standard
From Shortage to Surge: A Developmental Switch in Hippocampal-Prefrontal Coupling in a Gene-Environment Model of Neuropsychiatric Disorders. / Hartung, Henrike; Cichon, Nicole; De Feo, Vito; Riemann, Stephanie ; Schildt, Sandra; Lindemann, Christoph; Mulert, Christoph; Gogos, Joseph A; Hanganu-Opatz, Ileana L.
In: CEREB CORTEX, Vol. 26, No. 11, 10.2016, p. 4265-4281.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - From Shortage to Surge: A Developmental Switch in Hippocampal-Prefrontal Coupling in a Gene-Environment Model of Neuropsychiatric Disorders
AU - Hartung, Henrike
AU - Cichon, Nicole
AU - De Feo, Vito
AU - Riemann, Stephanie
AU - Schildt, Sandra
AU - Lindemann, Christoph
AU - Mulert, Christoph
AU - Gogos, Joseph A
AU - Hanganu-Opatz, Ileana L
N1 - © The Author 2016. Published by Oxford University Press.
PY - 2016/10
Y1 - 2016/10
N2 - Cognitive deficits represent a major burden of neuropsychiatric disorders and result in part from abnormal communication within hippocampal-prefrontal circuits. While it has been hypothesized that this network dysfunction arises during development, long before the first clinical symptoms, experimental evidence is still missing. Here, we show that pre-juvenile mice mimicking genetic and environmental risk factors of disease (dual-hit GE mice) have poorer recognition memory that correlates with augmented coupling by synchrony and stronger directed interactions between prefrontal cortex and hippocampus. The network dysfunction emerges already during neonatal development, yet it initially consists in a diminished hippocampal theta drive and consequently, a weaker and disorganized entrainment of local prefrontal circuits in discontinuous oscillatory activity in dual-hit GE mice when compared with controls. Thus, impaired maturation of functional communication within hippocampal-prefrontal networks switching from hypo- to hyper-coupling may represent a mechanism underlying the pathophysiology of cognitive deficits in neuropsychiatric disorders.
AB - Cognitive deficits represent a major burden of neuropsychiatric disorders and result in part from abnormal communication within hippocampal-prefrontal circuits. While it has been hypothesized that this network dysfunction arises during development, long before the first clinical symptoms, experimental evidence is still missing. Here, we show that pre-juvenile mice mimicking genetic and environmental risk factors of disease (dual-hit GE mice) have poorer recognition memory that correlates with augmented coupling by synchrony and stronger directed interactions between prefrontal cortex and hippocampus. The network dysfunction emerges already during neonatal development, yet it initially consists in a diminished hippocampal theta drive and consequently, a weaker and disorganized entrainment of local prefrontal circuits in discontinuous oscillatory activity in dual-hit GE mice when compared with controls. Thus, impaired maturation of functional communication within hippocampal-prefrontal networks switching from hypo- to hyper-coupling may represent a mechanism underlying the pathophysiology of cognitive deficits in neuropsychiatric disorders.
U2 - 10.1093/cercor/bhw274
DO - 10.1093/cercor/bhw274
M3 - SCORING: Journal article
C2 - 27613435
VL - 26
SP - 4265
EP - 4281
JO - CEREB CORTEX
JF - CEREB CORTEX
SN - 1047-3211
IS - 11
ER -
