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From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence

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From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence. / Kühn, Simone; Witt, Charlotte; Banaschewski, Tobias; Barbot, Alexis; Barker, Gareth J; Büchel, Christian; Conrod, Patricia J; Flor, Herta; Garavan, Hugh; Ittermann, Bernd; Mann, Karl; Martinot, Jean-Luc; Paus, Tomas; Rietschel, Marcella; Smolka, Michael N; Ströhle, Andreas; Brühl, Rüdiger; Schumann, Gunter; Heinz, Andreas; Gallinat, Jürgen; IMAGEN Consortium.

In: ADDICT BIOL, 24.04.2015.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kühn, S, Witt, C, Banaschewski, T, Barbot, A, Barker, GJ, Büchel, C, Conrod, PJ, Flor, H, Garavan, H, Ittermann, B, Mann, K, Martinot, J-L, Paus, T, Rietschel, M, Smolka, MN, Ströhle, A, Brühl, R, Schumann, G, Heinz, A, Gallinat, J & IMAGEN Consortium 2015, 'From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence', ADDICT BIOL. https://doi.org/10.1111/adb.12240

APA

Kühn, S., Witt, C., Banaschewski, T., Barbot, A., Barker, G. J., Büchel, C., Conrod, P. J., Flor, H., Garavan, H., Ittermann, B., Mann, K., Martinot, J-L., Paus, T., Rietschel, M., Smolka, M. N., Ströhle, A., Brühl, R., Schumann, G., Heinz, A., ... IMAGEN Consortium (2015). From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence. ADDICT BIOL. https://doi.org/10.1111/adb.12240

Vancouver

Kühn S, Witt C, Banaschewski T, Barbot A, Barker GJ, Büchel C et al. From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence. ADDICT BIOL. 2015 Apr 24. https://doi.org/10.1111/adb.12240

Bibtex

@article{15d62447bb56498fbc92af68e55a7500,
title = "From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence",
abstract = "Adolescence is a common time for initiation of alcohol use and alcohol use disorders. Importantly, the neuro-anatomical foundation for later alcohol-related problems may already manifest pre-natally, particularly due to smoking and alcohol consumption during pregnancy. In this context, cortical gyrification is an interesting marker of neuronal development but has not been investigated as a risk factor for adolescent alcohol use. On magnetic resonance imaging scans of 595 14-year-old adolescents from the IMAGEN sample, we computed whole-brain mean curvature indices to predict change in alcohol-related problems over the following 2 years. Change of alcohol use-related problems was significantly predicted from mean curvature in left orbitofrontal cortex (OFC). Less gyrification of OFC was associated with an increase in alcohol use-related problems over the next 2 years. Moreover, lower gyrification in left OFC was related to pre-natal alcohol exposure, whereas maternal smoking during pregnancy had no effect. Current alcohol use-related problems of the biological mother had no effect on offsprings' OFC gyrification or drinking behaviour. The data support the idea that alcohol consumption during pregnancy mediates the development of neuro-anatomical phenotypes, which in turn constitute a risk factor for increasing problems due to alcohol consumption in a vulnerable stage of life. Maternal smoking during pregnancy or current maternal alcohol/nicotine consumption had no significant effect. The OFC mediates behaviours known to be disturbed in addiction, namely impulse control and reward processing. The results stress the importance of pre-natal alcohol exposure for later increases in alcohol use-related problems, mediated by structural brain characteristics.",
author = "Simone K{\"u}hn and Charlotte Witt and Tobias Banaschewski and Alexis Barbot and Barker, {Gareth J} and Christian B{\"u}chel and Conrod, {Patricia J} and Herta Flor and Hugh Garavan and Bernd Ittermann and Karl Mann and Jean-Luc Martinot and Tomas Paus and Marcella Rietschel and Smolka, {Michael N} and Andreas Str{\"o}hle and R{\"u}diger Br{\"u}hl and Gunter Schumann and Andreas Heinz and J{\"u}rgen Gallinat and {IMAGEN Consortium}",
note = "{\textcopyright} 2015 Society for the Study of Addiction.",
year = "2015",
month = apr,
day = "24",
doi = "10.1111/adb.12240",
language = "English",
journal = "ADDICT BIOL",
issn = "1355-6215",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence

AU - Kühn, Simone

AU - Witt, Charlotte

AU - Banaschewski, Tobias

AU - Barbot, Alexis

AU - Barker, Gareth J

AU - Büchel, Christian

AU - Conrod, Patricia J

AU - Flor, Herta

AU - Garavan, Hugh

AU - Ittermann, Bernd

AU - Mann, Karl

AU - Martinot, Jean-Luc

AU - Paus, Tomas

AU - Rietschel, Marcella

AU - Smolka, Michael N

AU - Ströhle, Andreas

AU - Brühl, Rüdiger

AU - Schumann, Gunter

AU - Heinz, Andreas

AU - Gallinat, Jürgen

AU - IMAGEN Consortium

N1 - © 2015 Society for the Study of Addiction.

PY - 2015/4/24

Y1 - 2015/4/24

N2 - Adolescence is a common time for initiation of alcohol use and alcohol use disorders. Importantly, the neuro-anatomical foundation for later alcohol-related problems may already manifest pre-natally, particularly due to smoking and alcohol consumption during pregnancy. In this context, cortical gyrification is an interesting marker of neuronal development but has not been investigated as a risk factor for adolescent alcohol use. On magnetic resonance imaging scans of 595 14-year-old adolescents from the IMAGEN sample, we computed whole-brain mean curvature indices to predict change in alcohol-related problems over the following 2 years. Change of alcohol use-related problems was significantly predicted from mean curvature in left orbitofrontal cortex (OFC). Less gyrification of OFC was associated with an increase in alcohol use-related problems over the next 2 years. Moreover, lower gyrification in left OFC was related to pre-natal alcohol exposure, whereas maternal smoking during pregnancy had no effect. Current alcohol use-related problems of the biological mother had no effect on offsprings' OFC gyrification or drinking behaviour. The data support the idea that alcohol consumption during pregnancy mediates the development of neuro-anatomical phenotypes, which in turn constitute a risk factor for increasing problems due to alcohol consumption in a vulnerable stage of life. Maternal smoking during pregnancy or current maternal alcohol/nicotine consumption had no significant effect. The OFC mediates behaviours known to be disturbed in addiction, namely impulse control and reward processing. The results stress the importance of pre-natal alcohol exposure for later increases in alcohol use-related problems, mediated by structural brain characteristics.

AB - Adolescence is a common time for initiation of alcohol use and alcohol use disorders. Importantly, the neuro-anatomical foundation for later alcohol-related problems may already manifest pre-natally, particularly due to smoking and alcohol consumption during pregnancy. In this context, cortical gyrification is an interesting marker of neuronal development but has not been investigated as a risk factor for adolescent alcohol use. On magnetic resonance imaging scans of 595 14-year-old adolescents from the IMAGEN sample, we computed whole-brain mean curvature indices to predict change in alcohol-related problems over the following 2 years. Change of alcohol use-related problems was significantly predicted from mean curvature in left orbitofrontal cortex (OFC). Less gyrification of OFC was associated with an increase in alcohol use-related problems over the next 2 years. Moreover, lower gyrification in left OFC was related to pre-natal alcohol exposure, whereas maternal smoking during pregnancy had no effect. Current alcohol use-related problems of the biological mother had no effect on offsprings' OFC gyrification or drinking behaviour. The data support the idea that alcohol consumption during pregnancy mediates the development of neuro-anatomical phenotypes, which in turn constitute a risk factor for increasing problems due to alcohol consumption in a vulnerable stage of life. Maternal smoking during pregnancy or current maternal alcohol/nicotine consumption had no significant effect. The OFC mediates behaviours known to be disturbed in addiction, namely impulse control and reward processing. The results stress the importance of pre-natal alcohol exposure for later increases in alcohol use-related problems, mediated by structural brain characteristics.

U2 - 10.1111/adb.12240

DO - 10.1111/adb.12240

M3 - SCORING: Journal article

C2 - 25913102

JO - ADDICT BIOL

JF - ADDICT BIOL

SN - 1355-6215

ER -