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Frequency of sleep apnea in adults with the Marfan syndrome.

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Frequency of sleep apnea in adults with the Marfan syndrome. / Rybczynski, Meike; Koschyk, Dietmar; Karmeier, Andreas; Gessler, Nele; Sheikhzadeh, Sara; Bernhardt, Alexander; Habermann, Christian; Treede, Hendrik; Berger, Jürgen; Robinson, Peter N; Meinertz, Thomas; Von Kodolitsch, Yskert.

In: AM J CARDIOL, Vol. 105, No. 12, 12, 2010, p. 1836-1841.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rybczynski, M, Koschyk, D, Karmeier, A, Gessler, N, Sheikhzadeh, S, Bernhardt, A, Habermann, C, Treede, H, Berger, J, Robinson, PN, Meinertz, T & Von Kodolitsch, Y 2010, 'Frequency of sleep apnea in adults with the Marfan syndrome.', AM J CARDIOL, vol. 105, no. 12, 12, pp. 1836-1841. <http://www.ncbi.nlm.nih.gov/pubmed/20538140?dopt=Citation>

APA

Rybczynski, M., Koschyk, D., Karmeier, A., Gessler, N., Sheikhzadeh, S., Bernhardt, A., Habermann, C., Treede, H., Berger, J., Robinson, P. N., Meinertz, T., & Von Kodolitsch, Y. (2010). Frequency of sleep apnea in adults with the Marfan syndrome. AM J CARDIOL, 105(12), 1836-1841. [12]. http://www.ncbi.nlm.nih.gov/pubmed/20538140?dopt=Citation

Vancouver

Rybczynski M, Koschyk D, Karmeier A, Gessler N, Sheikhzadeh S, Bernhardt A et al. Frequency of sleep apnea in adults with the Marfan syndrome. AM J CARDIOL. 2010;105(12):1836-1841. 12.

Bibtex

@article{c5ce973662ac42449769b1a3f7871383,
title = "Frequency of sleep apnea in adults with the Marfan syndrome.",
abstract = "Obstructive and central sleep apneas are treatable disorders, which contribute to cardiovascular morbidity in older adults. Younger adults with Marfan syndrome may also be at risk for sleep apnea, but the relation between cardiovascular complications and sleep apnea is unknown. We used MiniScreen8 portable monitoring devices for polygraphy in 68 consecutive adults with Marfan syndrome (33 men, 35 women, 41 +/- 14 years old) to investigate frequency of sleep apnea and its relation to cardiovascular morbidity. The apnea-hypopnea index (AHI) was 6 to 15/hour in 14 subjects (mild sleep apnea, 21%), and AHI was >15/hour in 7 subjects (moderate or severe sleep apnea, 10%). Among established risk factors for sleep apnea, only older age (Spearman rho = 0.35, p = 0.004) and body mass index (rho = 0.26, p = 0.03) were associated with increased AHI. Of all cases of apnea, 12 +/- 27 were obstructive, 11 +/- 25 central, and 3 +/- 9 mixed. AHI was associated with decreased left ventricular ejection fraction (rho = -0.33, p = 0.01), increased N-terminal pro-brain natriuretic peptide levels (rho = 0.35, p = 0.004), enlarged descending aortic diameters (rho = 0.44, p = 0.001), atrial fibrillation (phi = 0.43, p = 0.002), and mitral valve surgery (phi = 0.34, p = 0.02). Of these, left ventricular ejection fraction, N-terminal pro-brain natriuretic peptide levels, atrial fibrillation, and mitral valve surgery were associated with AHI independently of age and body mass index. We found similar associations with oxygen desaturation index. In conclusion, sleep apnea exhibits increased frequency in Marfan syndrome and is not predicted by classic risk factors. Obstructive and central sleep apneas may relate to cardiovascular disease variables.",
author = "Meike Rybczynski and Dietmar Koschyk and Andreas Karmeier and Nele Gessler and Sara Sheikhzadeh and Alexander Bernhardt and Christian Habermann and Hendrik Treede and J{\"u}rgen Berger and Robinson, {Peter N} and Thomas Meinertz and {Von Kodolitsch}, Yskert",
year = "2010",
language = "Deutsch",
volume = "105",
pages = "1836--1841",
journal = "AM J CARDIOL",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Frequency of sleep apnea in adults with the Marfan syndrome.

AU - Rybczynski, Meike

AU - Koschyk, Dietmar

AU - Karmeier, Andreas

AU - Gessler, Nele

AU - Sheikhzadeh, Sara

AU - Bernhardt, Alexander

AU - Habermann, Christian

AU - Treede, Hendrik

AU - Berger, Jürgen

AU - Robinson, Peter N

AU - Meinertz, Thomas

AU - Von Kodolitsch, Yskert

PY - 2010

Y1 - 2010

N2 - Obstructive and central sleep apneas are treatable disorders, which contribute to cardiovascular morbidity in older adults. Younger adults with Marfan syndrome may also be at risk for sleep apnea, but the relation between cardiovascular complications and sleep apnea is unknown. We used MiniScreen8 portable monitoring devices for polygraphy in 68 consecutive adults with Marfan syndrome (33 men, 35 women, 41 +/- 14 years old) to investigate frequency of sleep apnea and its relation to cardiovascular morbidity. The apnea-hypopnea index (AHI) was 6 to 15/hour in 14 subjects (mild sleep apnea, 21%), and AHI was >15/hour in 7 subjects (moderate or severe sleep apnea, 10%). Among established risk factors for sleep apnea, only older age (Spearman rho = 0.35, p = 0.004) and body mass index (rho = 0.26, p = 0.03) were associated with increased AHI. Of all cases of apnea, 12 +/- 27 were obstructive, 11 +/- 25 central, and 3 +/- 9 mixed. AHI was associated with decreased left ventricular ejection fraction (rho = -0.33, p = 0.01), increased N-terminal pro-brain natriuretic peptide levels (rho = 0.35, p = 0.004), enlarged descending aortic diameters (rho = 0.44, p = 0.001), atrial fibrillation (phi = 0.43, p = 0.002), and mitral valve surgery (phi = 0.34, p = 0.02). Of these, left ventricular ejection fraction, N-terminal pro-brain natriuretic peptide levels, atrial fibrillation, and mitral valve surgery were associated with AHI independently of age and body mass index. We found similar associations with oxygen desaturation index. In conclusion, sleep apnea exhibits increased frequency in Marfan syndrome and is not predicted by classic risk factors. Obstructive and central sleep apneas may relate to cardiovascular disease variables.

AB - Obstructive and central sleep apneas are treatable disorders, which contribute to cardiovascular morbidity in older adults. Younger adults with Marfan syndrome may also be at risk for sleep apnea, but the relation between cardiovascular complications and sleep apnea is unknown. We used MiniScreen8 portable monitoring devices for polygraphy in 68 consecutive adults with Marfan syndrome (33 men, 35 women, 41 +/- 14 years old) to investigate frequency of sleep apnea and its relation to cardiovascular morbidity. The apnea-hypopnea index (AHI) was 6 to 15/hour in 14 subjects (mild sleep apnea, 21%), and AHI was >15/hour in 7 subjects (moderate or severe sleep apnea, 10%). Among established risk factors for sleep apnea, only older age (Spearman rho = 0.35, p = 0.004) and body mass index (rho = 0.26, p = 0.03) were associated with increased AHI. Of all cases of apnea, 12 +/- 27 were obstructive, 11 +/- 25 central, and 3 +/- 9 mixed. AHI was associated with decreased left ventricular ejection fraction (rho = -0.33, p = 0.01), increased N-terminal pro-brain natriuretic peptide levels (rho = 0.35, p = 0.004), enlarged descending aortic diameters (rho = 0.44, p = 0.001), atrial fibrillation (phi = 0.43, p = 0.002), and mitral valve surgery (phi = 0.34, p = 0.02). Of these, left ventricular ejection fraction, N-terminal pro-brain natriuretic peptide levels, atrial fibrillation, and mitral valve surgery were associated with AHI independently of age and body mass index. We found similar associations with oxygen desaturation index. In conclusion, sleep apnea exhibits increased frequency in Marfan syndrome and is not predicted by classic risk factors. Obstructive and central sleep apneas may relate to cardiovascular disease variables.

M3 - SCORING: Zeitschriftenaufsatz

VL - 105

SP - 1836

EP - 1841

JO - AM J CARDIOL

JF - AM J CARDIOL

SN - 0002-9149

IS - 12

M1 - 12

ER -