Frequency and prognostic significance of incidental prostate cancer at radical cystectomy: Results from an international retrospective study
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Frequency and prognostic significance of incidental prostate cancer at radical cystectomy: Results from an international retrospective study. / Malte, Rieken; Kluth, Luis A; Kaushik, Dharam; Boorjian, Stephen A; Abufaraj, Mohammad; Foerster, Beat; Rink, Michael; Gust, Kilian; Roghmann, Florian; Noldus, Joachim; Vordos, Dimitri; Hagiwara, Masayuki; Kikuchi, Eiji; Ikeda, Masaomi; Matsumoto, Kazumasa; Karakiewicz, Pierre I; Rouprêt, Morgan; Briganti, Alberto; Scherr, Douglas S; Shariat, Shahrokh F; Seebacher, Veronika.
In: EJSO-EUR J SURG ONC, Vol. 43, No. 11, 11.2017, p. 2193-2199.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Frequency and prognostic significance of incidental prostate cancer at radical cystectomy: Results from an international retrospective study
AU - Malte, Rieken
AU - Kluth, Luis A
AU - Kaushik, Dharam
AU - Boorjian, Stephen A
AU - Abufaraj, Mohammad
AU - Foerster, Beat
AU - Rink, Michael
AU - Gust, Kilian
AU - Roghmann, Florian
AU - Noldus, Joachim
AU - Vordos, Dimitri
AU - Hagiwara, Masayuki
AU - Kikuchi, Eiji
AU - Ikeda, Masaomi
AU - Matsumoto, Kazumasa
AU - Karakiewicz, Pierre I
AU - Rouprêt, Morgan
AU - Briganti, Alberto
AU - Scherr, Douglas S
AU - Shariat, Shahrokh F
AU - Seebacher, Veronika
N1 - Copyright © 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
PY - 2017/11
Y1 - 2017/11
N2 - OBJECTIVES: To analyze the frequency of incidental prostate cancer (PC) at radical cystoprostatectomy (RC) for urothelial carcinoma of the bladder (UCB) and its association with survival outcomes in an international cohort.PATIENTS AND METHODS: In this retrospective study, we included 2114 who underwent RC and lymphadenectomy for UCB between 1976 and 2012 male patients from seven institutions. Univariable and multivariable Cox regression models addressed the association of incidental PC with cancer-specific mortality and overall mortality after RC.RESULTS: Overall, incidental PC was found in 513 (24.3%) patients with the lowest frequency in a Japanese center (23/164, 11.2%) and the highest frequency in a North American center (122/325, 37.5%), respectively (p < 0.001). Within a median follow up of 27 months (IQR: 50 months), 20 patients (3.9%) were diagnosed with biochemical recurrence (BCR) and none of the patients died of PC. PC pathological tumor stage was more advanced in patients experiencing BCR (p < 0.001). In multivariable Cox regression analyses adjusted for standard clinicopathologic features, incidental PC was not associated with cancer-specific (HR: 1.11, 95% CI: 0.91-1.35, p = 0.30) or overall mortality (HR: 1.06, 95% CI: 0.83-1.35, p = 0.65).CONCLUSIONS: Incidental PC at RC for UCB is a frequent event. However, the majority of PC cases are well-differentiated and organ-confined. Presence of incidental PC shows significant geographic differences. The risk of BCR after incidental PC is low and incidental PC is not associated with survival in UCB patients treated with RC.
AB - OBJECTIVES: To analyze the frequency of incidental prostate cancer (PC) at radical cystoprostatectomy (RC) for urothelial carcinoma of the bladder (UCB) and its association with survival outcomes in an international cohort.PATIENTS AND METHODS: In this retrospective study, we included 2114 who underwent RC and lymphadenectomy for UCB between 1976 and 2012 male patients from seven institutions. Univariable and multivariable Cox regression models addressed the association of incidental PC with cancer-specific mortality and overall mortality after RC.RESULTS: Overall, incidental PC was found in 513 (24.3%) patients with the lowest frequency in a Japanese center (23/164, 11.2%) and the highest frequency in a North American center (122/325, 37.5%), respectively (p < 0.001). Within a median follow up of 27 months (IQR: 50 months), 20 patients (3.9%) were diagnosed with biochemical recurrence (BCR) and none of the patients died of PC. PC pathological tumor stage was more advanced in patients experiencing BCR (p < 0.001). In multivariable Cox regression analyses adjusted for standard clinicopathologic features, incidental PC was not associated with cancer-specific (HR: 1.11, 95% CI: 0.91-1.35, p = 0.30) or overall mortality (HR: 1.06, 95% CI: 0.83-1.35, p = 0.65).CONCLUSIONS: Incidental PC at RC for UCB is a frequent event. However, the majority of PC cases are well-differentiated and organ-confined. Presence of incidental PC shows significant geographic differences. The risk of BCR after incidental PC is low and incidental PC is not associated with survival in UCB patients treated with RC.
KW - Aged
KW - Cystectomy
KW - Humans
KW - Incidental Findings
KW - Lymph Node Excision
KW - Male
KW - Middle Aged
KW - Neoplasm Staging
KW - Prognosis
KW - Prostatic Neoplasms
KW - Retrospective Studies
KW - Survival Rate
KW - Treatment Outcome
KW - Urinary Bladder Neoplasms
KW - Journal Article
KW - Multicenter Study
U2 - 10.1016/j.ejso.2017.08.013
DO - 10.1016/j.ejso.2017.08.013
M3 - SCORING: Journal article
C2 - 28928012
VL - 43
SP - 2193
EP - 2199
JO - EJSO-EUR J SURG ONC
JF - EJSO-EUR J SURG ONC
SN - 0748-7983
IS - 11
ER -
