Frequency and age-related course of mitral valve dysfunction in the Marfan syndrome

Meike Rybczynski; Thomas S Mir; Sara Sheikhzadeh; Alexander M J Bernhardt; Claudia Schad; Hendrik Treede; Simon Veldhoen; Eike F Groene; Kristin Kühne; Dietmar Koschyk; Peter N Robinson; Jürgen Berger; Hermann Reichenspurner; Thomas Meinertz; Yskert von Kodolitsch

doi:10.1016/j.amjcard.2010.05.038

Frequency and age-related course of mitral valve dysfunction in the Marfan syndrome

Standard

Frequency and age-related course of mitral valve dysfunction in the Marfan syndrome. / Rybczynski, Meike ; Mir, Thomas S; Sheikhzadeh, Sara; Bernhardt, Alexander M J; Schad, Claudia; Treede, Hendrik; Veldhoen, Simon; Groene, Eike F; Kühne, Kristin; Koschyk, Dietmar; Robinson, Peter N; Berger, Jürgen; Reichenspurner, Hermann; Meinertz, Thomas; von Kodolitsch, Yskert.

In: AM J CARDIOL, Vol. 106, No. 7, 7, 01.10.2010, p. 1048-1053.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rybczynski, M , Mir, TS, Sheikhzadeh, S, Bernhardt, AMJ, Schad, C, Treede, H, Veldhoen, S, Groene, EF, Kühne, K, Koschyk, D, Robinson, PN, Berger, J, Reichenspurner, H, Meinertz, T & von Kodolitsch, Y 2010, 'Frequency and age-related course of mitral valve dysfunction in the Marfan syndrome', AM J CARDIOL, vol. 106, no. 7, 7, pp. 1048-1053. https://doi.org/10.1016/j.amjcard.2010.05.038

APA

Rybczynski, M., Mir, T. S., Sheikhzadeh, S., Bernhardt, A. M. J., Schad, C., Treede, H., Veldhoen, S., Groene, E. F., Kühne, K., Koschyk, D., Robinson, P. N., Berger, J., Reichenspurner, H., Meinertz, T., & von Kodolitsch, Y. (2010). Frequency and age-related course of mitral valve dysfunction in the Marfan syndrome. AM J CARDIOL, 106(7), 1048-1053. [7]. https://doi.org/10.1016/j.amjcard.2010.05.038

Vancouver

Rybczynski M , Mir TS, Sheikhzadeh S, Bernhardt AMJ, Schad C, Treede H et al. Frequency and age-related course of mitral valve dysfunction in the Marfan syndrome. AM J CARDIOL. 2010 Oct 1;106(7):1048-1053. 7. https://doi.org/10.1016/j.amjcard.2010.05.038

Bibtex

@article{bb70fe74223f45eeabe40d9bf8eb1cb1,

title = "Frequency and age-related course of mitral valve dysfunction in the Marfan syndrome",

abstract = "Mitral valve (MV) prolapse (MVP) has a high prevalence of 2% to 3% in the general population and thus constitutes the most common cause of severe nonischemic MV regurgitation (MVR). MVP is also common in persons with the Marfan syndrome. However, to date, a large-scale population-based cohort study using modern echocardiographic techniques has not been performed, and the frequency of MVP and the relation of MV dysfunction and age have not been investigated. Therefore, we conducted a population-based cohort study of 204 patients (108 males and 96 females, aged 31.2 ± 16.4 years) with classic Marfan syndrome. We performed echocardiographic follow-up of 174 patients for a mean of 4.4 ± 4.3 years. On the initial or subsequent echocardiographic scan, MVP was present in 82 patients (40%), severe MVR in 25 (12%), and MV endocarditis in 5 patients (2.5%). At 30 years of age, the Weibull cumulative distribution was 42.6% (95% confidence interval [CI] 36% to 50%) for MVP, 56.5% (95% CI 49.3% to 64%) for MVR of any degree, 6.7% (95% CI 3.9% to 11.3%) for severe MVR, and 0.92% (95% CI 0.21% to 3.91%) for MV endocarditis. The cumulative hazard for severe MVR and MV endocarditis was estimated to increase with age. MVP was associated with dural ectasia (p = 0.01), ectopia lentis (p = 0.02), and skeletal involvement (p",

keywords = "Adult, Age Factors, Female, Humans, Male, Marfan Syndrome/complications, Middle Aged, Mitral Valve Prolapse/complications, Ultrasonography",

author = "Meike Rybczynski and Mir, {Thomas S} and Sara Sheikhzadeh and Bernhardt, {Alexander M J} and Claudia Schad and Hendrik Treede and Simon Veldhoen and Groene, {Eike F} and Kristin K{\"u}hne and Dietmar Koschyk and Robinson, {Peter N} and J{\"u}rgen Berger and Hermann Reichenspurner and Thomas Meinertz and {von Kodolitsch}, Yskert",

year = "2010",

month = oct,

day = "1",

doi = "10.1016/j.amjcard.2010.05.038",

language = "English",

volume = "106",

pages = "1048--1053",

journal = "AM J CARDIOL",

issn = "0002-9149",

publisher = "Elsevier Inc.",

number = "7",

}

RIS

TY - JOUR

T1 - Frequency and age-related course of mitral valve dysfunction in the Marfan syndrome

AU - Rybczynski, Meike

AU - Mir, Thomas S

AU - Sheikhzadeh, Sara

AU - Bernhardt, Alexander M J

AU - Schad, Claudia

AU - Treede, Hendrik

AU - Veldhoen, Simon

AU - Groene, Eike F

AU - Kühne, Kristin

AU - Koschyk, Dietmar

AU - Robinson, Peter N

AU - Berger, Jürgen

AU - Reichenspurner, Hermann

AU - Meinertz, Thomas

AU - von Kodolitsch, Yskert

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Mitral valve (MV) prolapse (MVP) has a high prevalence of 2% to 3% in the general population and thus constitutes the most common cause of severe nonischemic MV regurgitation (MVR). MVP is also common in persons with the Marfan syndrome. However, to date, a large-scale population-based cohort study using modern echocardiographic techniques has not been performed, and the frequency of MVP and the relation of MV dysfunction and age have not been investigated. Therefore, we conducted a population-based cohort study of 204 patients (108 males and 96 females, aged 31.2 ± 16.4 years) with classic Marfan syndrome. We performed echocardiographic follow-up of 174 patients for a mean of 4.4 ± 4.3 years. On the initial or subsequent echocardiographic scan, MVP was present in 82 patients (40%), severe MVR in 25 (12%), and MV endocarditis in 5 patients (2.5%). At 30 years of age, the Weibull cumulative distribution was 42.6% (95% confidence interval [CI] 36% to 50%) for MVP, 56.5% (95% CI 49.3% to 64%) for MVR of any degree, 6.7% (95% CI 3.9% to 11.3%) for severe MVR, and 0.92% (95% CI 0.21% to 3.91%) for MV endocarditis. The cumulative hazard for severe MVR and MV endocarditis was estimated to increase with age. MVP was associated with dural ectasia (p = 0.01), ectopia lentis (p = 0.02), and skeletal involvement (p

AB - Mitral valve (MV) prolapse (MVP) has a high prevalence of 2% to 3% in the general population and thus constitutes the most common cause of severe nonischemic MV regurgitation (MVR). MVP is also common in persons with the Marfan syndrome. However, to date, a large-scale population-based cohort study using modern echocardiographic techniques has not been performed, and the frequency of MVP and the relation of MV dysfunction and age have not been investigated. Therefore, we conducted a population-based cohort study of 204 patients (108 males and 96 females, aged 31.2 ± 16.4 years) with classic Marfan syndrome. We performed echocardiographic follow-up of 174 patients for a mean of 4.4 ± 4.3 years. On the initial or subsequent echocardiographic scan, MVP was present in 82 patients (40%), severe MVR in 25 (12%), and MV endocarditis in 5 patients (2.5%). At 30 years of age, the Weibull cumulative distribution was 42.6% (95% confidence interval [CI] 36% to 50%) for MVP, 56.5% (95% CI 49.3% to 64%) for MVR of any degree, 6.7% (95% CI 3.9% to 11.3%) for severe MVR, and 0.92% (95% CI 0.21% to 3.91%) for MV endocarditis. The cumulative hazard for severe MVR and MV endocarditis was estimated to increase with age. MVP was associated with dural ectasia (p = 0.01), ectopia lentis (p = 0.02), and skeletal involvement (p

KW - Adult

KW - Age Factors

KW - Female

KW - Humans

KW - Male

KW - Marfan Syndrome/complications

KW - Middle Aged

KW - Mitral Valve Prolapse/complications

KW - Ultrasonography

U2 - 10.1016/j.amjcard.2010.05.038

DO - 10.1016/j.amjcard.2010.05.038

M3 - SCORING: Journal article

C2 - 20854973

VL - 106

SP - 1048

EP - 1053

JO - AM J CARDIOL

JF - AM J CARDIOL

SN - 0002-9149

IS - 7

M1 - 7

ER -