Free thyroxine, cognitive decline and depression in Alzheimer's disease.
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Free thyroxine, cognitive decline and depression in Alzheimer's disease. / Stuerenburg, Hans Joerg; Arlt, Sönke; Mueller-Thomsen, Tomas.
In: NEUROENDOCRINOL LETT, Vol. 27, No. 4, 4, 2006, p. 535-537.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Free thyroxine, cognitive decline and depression in Alzheimer's disease.
AU - Stuerenburg, Hans Joerg
AU - Arlt, Sönke
AU - Mueller-Thomsen, Tomas
PY - 2006
Y1 - 2006
N2 - The role of thyroid function in Alzheimer's disease (AD) has been subject to a number of studies during the last years. We investigated the possible relationship between plasma levels of the biologically active free form of thyroxin (fT4) and cognitive function in 227 outpatients with mild to moderate Alzheimer s disease (AD) in a cross-sectional study design. A significant negative correlation was found between plasma fT4-levels and Mini-Mental state examination (MMSE) score (Spearman Rho = -0.14, p=0.04). When the lowest quartile of fT4-levels (19.0 pmol/l), statistically significant lower mean MMSE-scores were seen in the group with the highest fT4-levels (p0.05). When fT4 quartile groups were compared for depression measured in the Geriatric Depression Score (GDS 15), a slightly higher score was seen in the 1s and 2nd compared to the 3rd and 4th quartile groups without reaching statistical significance (1st quartile of fT4: GDS 5.2 +/- 3.8; 2nd: 5.3 +/- 4.0; 3rd: 4.4 +/- 3.4; 4th: 4.5 +/- 3.8) pointing to a reverse correlation of fT4 levels and depressive mood. This study leads to the conclusion that high levels of plasma fT4 might result in a worsening of cognitive impairment and a positive effect on depressive mood in AD.
AB - The role of thyroid function in Alzheimer's disease (AD) has been subject to a number of studies during the last years. We investigated the possible relationship between plasma levels of the biologically active free form of thyroxin (fT4) and cognitive function in 227 outpatients with mild to moderate Alzheimer s disease (AD) in a cross-sectional study design. A significant negative correlation was found between plasma fT4-levels and Mini-Mental state examination (MMSE) score (Spearman Rho = -0.14, p=0.04). When the lowest quartile of fT4-levels (19.0 pmol/l), statistically significant lower mean MMSE-scores were seen in the group with the highest fT4-levels (p0.05). When fT4 quartile groups were compared for depression measured in the Geriatric Depression Score (GDS 15), a slightly higher score was seen in the 1s and 2nd compared to the 3rd and 4th quartile groups without reaching statistical significance (1st quartile of fT4: GDS 5.2 +/- 3.8; 2nd: 5.3 +/- 4.0; 3rd: 4.4 +/- 3.4; 4th: 4.5 +/- 3.8) pointing to a reverse correlation of fT4 levels and depressive mood. This study leads to the conclusion that high levels of plasma fT4 might result in a worsening of cognitive impairment and a positive effect on depressive mood in AD.
M3 - SCORING: Zeitschriftenaufsatz
VL - 27
SP - 535
EP - 537
JO - NEUROENDOCRINOL LETT
JF - NEUROENDOCRINOL LETT
SN - 0172-780X
IS - 4
M1 - 4
ER -
