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Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production.

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Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production. / Bozec, Aline; Bakiri, Latifa; Jimenez, Maria; Schinke, Thorsten; Amling, Michael; Wagner, Erwin F.

In: J CELL BIOL, Vol. 190, No. 6, 6, 2010, p. 1093-1106.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bozec, A, Bakiri, L, Jimenez, M, Schinke, T, Amling, M & Wagner, EF 2010, 'Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production.', J CELL BIOL, vol. 190, no. 6, 6, pp. 1093-1106. <http://www.ncbi.nlm.nih.gov/pubmed/20837772?dopt=Citation>

APA

Bozec, A., Bakiri, L., Jimenez, M., Schinke, T., Amling, M., & Wagner, E. F. (2010). Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production. J CELL BIOL, 190(6), 1093-1106. [6]. http://www.ncbi.nlm.nih.gov/pubmed/20837772?dopt=Citation

Vancouver

Bozec A, Bakiri L, Jimenez M, Schinke T, Amling M, Wagner EF. Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production. J CELL BIOL. 2010;190(6):1093-1106. 6.

Bibtex

@article{0f0b8796148c4448aec44474e659e8d2,
title = "Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production.",
abstract = "The activator protein-1 (AP-1) transcription factor complex, in particular the Fos proteins, is an important regulator of bone homeostasis. Fra-2 (Fosl2), a Fos-related protein of the AP-1 family, is expressed in bone cells, and newborn mice lacking Fra-2 exhibit defects in chondrocytes and osteoclasts. Here we show that Fra-2-deficient osteoblasts display a differentiation defect both in vivo and in vitro. Moreover, Fra-2-overexpressing mice are osteosclerotic because of increased differentiation of osteoblasts, which appears to be cell autonomous. Importantly, the osteoblast-specific osteocalcin (Oc) gene and collagen1 2 (col1 2) are transcriptional targets of Fra-2 in both murine and human bone cells. In addition, Fra-2, Oc, and col1 are expressed in stromal cells of human chondroblastic and osteoblastic osteosarcomas (Os's) as well as during osteoblast differentiation of human Os cell lines. These findings reveal a novel function of Fra-2/AP-1 as a positive regulator of bone and matrix formation in mice and humans.",
author = "Aline Bozec and Latifa Bakiri and Maria Jimenez and Thorsten Schinke and Michael Amling and Wagner, {Erwin F}",
year = "2010",
language = "Deutsch",
volume = "190",
pages = "1093--1106",
journal = "J CELL BIOL",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production.

AU - Bozec, Aline

AU - Bakiri, Latifa

AU - Jimenez, Maria

AU - Schinke, Thorsten

AU - Amling, Michael

AU - Wagner, Erwin F

PY - 2010

Y1 - 2010

N2 - The activator protein-1 (AP-1) transcription factor complex, in particular the Fos proteins, is an important regulator of bone homeostasis. Fra-2 (Fosl2), a Fos-related protein of the AP-1 family, is expressed in bone cells, and newborn mice lacking Fra-2 exhibit defects in chondrocytes and osteoclasts. Here we show that Fra-2-deficient osteoblasts display a differentiation defect both in vivo and in vitro. Moreover, Fra-2-overexpressing mice are osteosclerotic because of increased differentiation of osteoblasts, which appears to be cell autonomous. Importantly, the osteoblast-specific osteocalcin (Oc) gene and collagen1 2 (col1 2) are transcriptional targets of Fra-2 in both murine and human bone cells. In addition, Fra-2, Oc, and col1 are expressed in stromal cells of human chondroblastic and osteoblastic osteosarcomas (Os's) as well as during osteoblast differentiation of human Os cell lines. These findings reveal a novel function of Fra-2/AP-1 as a positive regulator of bone and matrix formation in mice and humans.

AB - The activator protein-1 (AP-1) transcription factor complex, in particular the Fos proteins, is an important regulator of bone homeostasis. Fra-2 (Fosl2), a Fos-related protein of the AP-1 family, is expressed in bone cells, and newborn mice lacking Fra-2 exhibit defects in chondrocytes and osteoclasts. Here we show that Fra-2-deficient osteoblasts display a differentiation defect both in vivo and in vitro. Moreover, Fra-2-overexpressing mice are osteosclerotic because of increased differentiation of osteoblasts, which appears to be cell autonomous. Importantly, the osteoblast-specific osteocalcin (Oc) gene and collagen1 2 (col1 2) are transcriptional targets of Fra-2 in both murine and human bone cells. In addition, Fra-2, Oc, and col1 are expressed in stromal cells of human chondroblastic and osteoblastic osteosarcomas (Os's) as well as during osteoblast differentiation of human Os cell lines. These findings reveal a novel function of Fra-2/AP-1 as a positive regulator of bone and matrix formation in mice and humans.

M3 - SCORING: Zeitschriftenaufsatz

VL - 190

SP - 1093

EP - 1106

JO - J CELL BIOL

JF - J CELL BIOL

SN - 0021-9525

IS - 6

M1 - 6

ER -