Forecasting Survival Probabilities After Radiotherapy of Metastatic Epidural Spinal Cord Compression from Colorectal Cancer in the Elderly
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Forecasting Survival Probabilities After Radiotherapy of Metastatic Epidural Spinal Cord Compression from Colorectal Cancer in the Elderly. / Rades, Dirk; Bartscht, Tobias; Janssen, Stefan; Bajrovic, Amira; Segedin, Barbara; Schild, Steven E.
In: ANTICANCER RES, Vol. 36, No. 4, 04.2016, p. 1829-33.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Forecasting Survival Probabilities After Radiotherapy of Metastatic Epidural Spinal Cord Compression from Colorectal Cancer in the Elderly
AU - Rades, Dirk
AU - Bartscht, Tobias
AU - Janssen, Stefan
AU - Bajrovic, Amira
AU - Segedin, Barbara
AU - Schild, Steven E
N1 - Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
PY - 2016/4
Y1 - 2016/4
N2 - AIM: To develop a tool forecasting survival of elderly patients with metastatic epidural spinal cord compression (MESCC) from colorectal cancer (CRC).PATIENTS AND METHODS: Fifty-seven patients were retrospectively evaluated. Eleven characteristics were investigated for survival. Independent characteristics were used for the tool. Scores were obtained from dividing 6-month survival rates by 10. From summing these points, patient scores were obtained.RESULTS: On survival analysis (Cox regression model), organ metastases (p=0.006), performance status (p<0.001), pre-radiotherapy walking ability (p<0.001) and the dynamic of developing motor weakness (p=0.033) were significant factors affecting survival and were incorporated into the tool. Possible patient scores were 5, 9, 10, 13, 14, 16, 20 or 24 points. Three groups were created with scores of 5-10, 13-16 and 20-24 points, with 6-month survival rates of 4%, 23% and 79%, respectively (p<0.001).CONCLUSION: By applying this tool, it is possible to forecast the survival of elderly patients experiencing MESCC from CRC, which is important for optimal treatment personalization.
AB - AIM: To develop a tool forecasting survival of elderly patients with metastatic epidural spinal cord compression (MESCC) from colorectal cancer (CRC).PATIENTS AND METHODS: Fifty-seven patients were retrospectively evaluated. Eleven characteristics were investigated for survival. Independent characteristics were used for the tool. Scores were obtained from dividing 6-month survival rates by 10. From summing these points, patient scores were obtained.RESULTS: On survival analysis (Cox regression model), organ metastases (p=0.006), performance status (p<0.001), pre-radiotherapy walking ability (p<0.001) and the dynamic of developing motor weakness (p=0.033) were significant factors affecting survival and were incorporated into the tool. Possible patient scores were 5, 9, 10, 13, 14, 16, 20 or 24 points. Three groups were created with scores of 5-10, 13-16 and 20-24 points, with 6-month survival rates of 4%, 23% and 79%, respectively (p<0.001).CONCLUSION: By applying this tool, it is possible to forecast the survival of elderly patients experiencing MESCC from CRC, which is important for optimal treatment personalization.
KW - Aged
KW - Colorectal Neoplasms
KW - Female
KW - Humans
KW - Male
KW - Motor Activity
KW - Prognosis
KW - Proportional Hazards Models
KW - Spinal Cord Compression
KW - Spinal Neoplasms
KW - Journal Article
M3 - SCORING: Journal article
C2 - 27069166
VL - 36
SP - 1829
EP - 1833
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 4
ER -
