Focus on a rare clinical entity: unicuspid aortic valve disease
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Focus on a rare clinical entity: unicuspid aortic valve disease. / Naito, Shiho; Sequeira-Gross, Tatiana; Petersen, Johannes; Holst, Theresa; Reichenspurner, Hermann; Girdauskas, Evaldas.
In: EXPERT REV CARDIOVAS, Vol. 18, No. 9, 09.2020, p. 625-633.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Focus on a rare clinical entity: unicuspid aortic valve disease
AU - Naito, Shiho
AU - Sequeira-Gross, Tatiana
AU - Petersen, Johannes
AU - Holst, Theresa
AU - Reichenspurner, Hermann
AU - Girdauskas, Evaldas
PY - 2020/9
Y1 - 2020/9
N2 - INTRODUCTION: While the understanding of the pathophysiology and clinical implication of bicuspid aortic valves evolves rapidly, the natural history of unicuspid aortic valves is still poorly understood. Hence, a universally accepted diagnostic work-up process and therapy recommendations for UAV still have to be established.AREAS COVERED: This article aims to give an overview on the most recent literature addressing the pathophysiology, the diagnostic tools and appropriate surgical therapy options of unicuspid aortic valve. Due to the rare prevalence, the understanding of pathophysiology is still missing. Further, symptomatic aortic valve disease are seen much earlier life stage in this cohorts. Thus, it highlights the several surgical treatment options with pro and contra especially for the young adult cohorts.EXPERT OPINION: Large scale prospective observational studies using standardized diagnostic criteria are needed to reveal the clinical course. Further appropriate treatment strategies of unicuspid aortic valve patients is demanded.
AB - INTRODUCTION: While the understanding of the pathophysiology and clinical implication of bicuspid aortic valves evolves rapidly, the natural history of unicuspid aortic valves is still poorly understood. Hence, a universally accepted diagnostic work-up process and therapy recommendations for UAV still have to be established.AREAS COVERED: This article aims to give an overview on the most recent literature addressing the pathophysiology, the diagnostic tools and appropriate surgical therapy options of unicuspid aortic valve. Due to the rare prevalence, the understanding of pathophysiology is still missing. Further, symptomatic aortic valve disease are seen much earlier life stage in this cohorts. Thus, it highlights the several surgical treatment options with pro and contra especially for the young adult cohorts.EXPERT OPINION: Large scale prospective observational studies using standardized diagnostic criteria are needed to reveal the clinical course. Further appropriate treatment strategies of unicuspid aortic valve patients is demanded.
KW - Aortic Valve/physiopathology
KW - Aortic Valve Disease/physiopathology
KW - Heart Valve Diseases/physiopathology
KW - Humans
KW - Young Adult
U2 - 10.1080/14779072.2020.1811685
DO - 10.1080/14779072.2020.1811685
M3 - SCORING: Review article
C2 - 32811206
VL - 18
SP - 625
EP - 633
JO - EXPERT REV CARDIOVAS
JF - EXPERT REV CARDIOVAS
SN - 1477-9072
IS - 9
ER -