fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive training
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fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive training. / Andreou, Christina; Steinmann, Saskia; Leicht, Gregor; Kolbeck, Katharina; Moritz, Steffen; Mulert, Christoph.
In: NEUROIMAGE-CLIN, Vol. 20, 2018, p. 119-127.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive training
AU - Andreou, Christina
AU - Steinmann, Saskia
AU - Leicht, Gregor
AU - Kolbeck, Katharina
AU - Moritz, Steffen
AU - Mulert, Christoph
PY - 2018
Y1 - 2018
N2 - Background: Reasoning biases such as the jumping-to-conclusions bias (JTC) are thought to contribute to delusions. Interventions targeting these biases such as metacognitive training (MCT) may improve delusions. So far, it is not clear whether JTC depends on dopaminergic reward areas that constitute the main action locus of antipsychotic drugs, or on additional cortical areas. The present study aimed to investigate fMRI activation and functional connectivity patterns underlying JTC, and their changes following MCT, in patients with delusions.Methods: Participants were 25 healthy individuals and 26 patients with current delusions who were either medication-free or on stable medication without sufficient response. We assessed (1) BOLD activity in the task-positive (TPN), task-negative (TNN), and subcortical reward network (RN); (2) Psychophysiological interactions (PPI) of peak activation areas.Results: Presence of JTC (irrespective of group) was associated with lower RN activity during conclusion events, and with increased effective connectivity between TPN and TNN during draw events. Following MCT, changes were observed in TPN activity and in effective connectivity of inferior parietal cortex (part of the TPN) with all three target networks.Conclusion: JTC is associated not only with reward system areas that constitute the main target of antipsychotic drugs, but also with cortical areas, particularly of the TPN.
AB - Background: Reasoning biases such as the jumping-to-conclusions bias (JTC) are thought to contribute to delusions. Interventions targeting these biases such as metacognitive training (MCT) may improve delusions. So far, it is not clear whether JTC depends on dopaminergic reward areas that constitute the main action locus of antipsychotic drugs, or on additional cortical areas. The present study aimed to investigate fMRI activation and functional connectivity patterns underlying JTC, and their changes following MCT, in patients with delusions.Methods: Participants were 25 healthy individuals and 26 patients with current delusions who were either medication-free or on stable medication without sufficient response. We assessed (1) BOLD activity in the task-positive (TPN), task-negative (TNN), and subcortical reward network (RN); (2) Psychophysiological interactions (PPI) of peak activation areas.Results: Presence of JTC (irrespective of group) was associated with lower RN activity during conclusion events, and with increased effective connectivity between TPN and TNN during draw events. Following MCT, changes were observed in TPN activity and in effective connectivity of inferior parietal cortex (part of the TPN) with all three target networks.Conclusion: JTC is associated not only with reward system areas that constitute the main target of antipsychotic drugs, but also with cortical areas, particularly of the TPN.
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.nicl.2018.07.004
DO - 10.1016/j.nicl.2018.07.004
M3 - SCORING: Journal article
C2 - 30094162
VL - 20
SP - 119
EP - 127
JO - NEUROIMAGE-CLIN
JF - NEUROIMAGE-CLIN
SN - 2213-1582
ER -