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Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment

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Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. / Hrusak, Ondrej; Kalina, Tomas; Wolf, Joshua; Balduzzi, Adriana; Provenzi, Massimo; Rizzari, Carmelo; Rives, Susana; Del Pozo Carlavilla, María; Alonso, Maria E V; Domínguez-Pinilla, Nerea; Bourquin, Jean-Pierre; Schmiegelow, Kjeld; Attarbaschi, Andishe; Grillner, Pernilla; Mellgren, Karin; van der Werff Ten Bosch, Jutte; Pieters, Rob; Brozou, Triantafyllia; Borkhardt, Arndt; Escherich, Gabriele; Lauten, Melchior; Stanulla, Martin; Smith, Owen; Yeoh, Allen E J; Elitzur, Sarah; Vora, Ajay; Li, Chi-Kong; Ariffin, Hany; Kolenova, Alexandra; Dallapozza, Luciano; Farah, Roula; Lazic, Jelena; Manabe, Atsushi; Styczynski, Jan; Kovacs, Gabor; Ottoffy, Gabor; Felice, Maria S; Buldini, Barbara; Conter, Valentino; Stary, Jan; Schrappe, Martin.

In: EUR J CANCER, Vol. 132, 06.2020, p. 11-16.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hrusak, O, Kalina, T, Wolf, J, Balduzzi, A, Provenzi, M, Rizzari, C, Rives, S, Del Pozo Carlavilla, M, Alonso, MEV, Domínguez-Pinilla, N, Bourquin, J-P, Schmiegelow, K, Attarbaschi, A, Grillner, P, Mellgren, K, van der Werff Ten Bosch, J, Pieters, R, Brozou, T, Borkhardt, A, Escherich, G, Lauten, M, Stanulla, M, Smith, O, Yeoh, AEJ, Elitzur, S, Vora, A, Li, C-K, Ariffin, H, Kolenova, A, Dallapozza, L, Farah, R, Lazic, J, Manabe, A, Styczynski, J, Kovacs, G, Ottoffy, G, Felice, MS, Buldini, B, Conter, V, Stary, J & Schrappe, M 2020, 'Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment', EUR J CANCER, vol. 132, pp. 11-16. https://doi.org/10.1016/j.ejca.2020.03.021

APA

Hrusak, O., Kalina, T., Wolf, J., Balduzzi, A., Provenzi, M., Rizzari, C., Rives, S., Del Pozo Carlavilla, M., Alonso, M. E. V., Domínguez-Pinilla, N., Bourquin, J-P., Schmiegelow, K., Attarbaschi, A., Grillner, P., Mellgren, K., van der Werff Ten Bosch, J., Pieters, R., Brozou, T., Borkhardt, A., ... Schrappe, M. (2020). Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. EUR J CANCER, 132, 11-16. https://doi.org/10.1016/j.ejca.2020.03.021

Vancouver

Hrusak O, Kalina T, Wolf J, Balduzzi A, Provenzi M, Rizzari C et al. Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. EUR J CANCER. 2020 Jun;132:11-16. https://doi.org/10.1016/j.ejca.2020.03.021

Bibtex

@article{41b2a33ab45f4eb79002775b99b8c159,
title = "Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment",
abstract = "INTRODUCTION: Since the beginning of COVID-19 pandemic, it is known that the severe course of the disease occurs mostly among the elderly, whereas it is rare among children and young adults. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Thus, there is concern that children treated for cancer may allso be at risk for an unfavourable course of infection. Along the same line, anecdotal information from Wuhan, China, mentioned a severe course of COVID-19 in a child treated for leukaemia.AIM AND METHODS: We made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short Web-based survey.RESULTS: We received reports from 25 countries, where approximately 10,000 patients at risk are followed up. At the time of the survey, more than 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease, and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19.CONCLUSION: Thus, even children receiving anticancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.",
keywords = "Adolescent, Antineoplastic Agents/therapeutic use, Betacoronavirus, COVID-19, Child, Coronavirus Infections/complications, Female, Humans, Male, Neoplasms/complications, Pandemics, Pneumonia, Viral/complications, SARS-CoV-2, Surveys and Questionnaires",
author = "Ondrej Hrusak and Tomas Kalina and Joshua Wolf and Adriana Balduzzi and Massimo Provenzi and Carmelo Rizzari and Susana Rives and {Del Pozo Carlavilla}, Mar{\'i}a and Alonso, {Maria E V} and Nerea Dom{\'i}nguez-Pinilla and Jean-Pierre Bourquin and Kjeld Schmiegelow and Andishe Attarbaschi and Pernilla Grillner and Karin Mellgren and {van der Werff Ten Bosch}, Jutte and Rob Pieters and Triantafyllia Brozou and Arndt Borkhardt and Gabriele Escherich and Melchior Lauten and Martin Stanulla and Owen Smith and Yeoh, {Allen E J} and Sarah Elitzur and Ajay Vora and Chi-Kong Li and Hany Ariffin and Alexandra Kolenova and Luciano Dallapozza and Roula Farah and Jelena Lazic and Atsushi Manabe and Jan Styczynski and Gabor Kovacs and Gabor Ottoffy and Felice, {Maria S} and Barbara Buldini and Valentino Conter and Jan Stary and Martin Schrappe",
note = "Copyright {\textcopyright} 2020. Published by Elsevier Ltd.",
year = "2020",
month = jun,
doi = "10.1016/j.ejca.2020.03.021",
language = "English",
volume = "132",
pages = "11--16",
journal = "EUR J CANCER",
issn = "0959-8049",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment

AU - Hrusak, Ondrej

AU - Kalina, Tomas

AU - Wolf, Joshua

AU - Balduzzi, Adriana

AU - Provenzi, Massimo

AU - Rizzari, Carmelo

AU - Rives, Susana

AU - Del Pozo Carlavilla, María

AU - Alonso, Maria E V

AU - Domínguez-Pinilla, Nerea

AU - Bourquin, Jean-Pierre

AU - Schmiegelow, Kjeld

AU - Attarbaschi, Andishe

AU - Grillner, Pernilla

AU - Mellgren, Karin

AU - van der Werff Ten Bosch, Jutte

AU - Pieters, Rob

AU - Brozou, Triantafyllia

AU - Borkhardt, Arndt

AU - Escherich, Gabriele

AU - Lauten, Melchior

AU - Stanulla, Martin

AU - Smith, Owen

AU - Yeoh, Allen E J

AU - Elitzur, Sarah

AU - Vora, Ajay

AU - Li, Chi-Kong

AU - Ariffin, Hany

AU - Kolenova, Alexandra

AU - Dallapozza, Luciano

AU - Farah, Roula

AU - Lazic, Jelena

AU - Manabe, Atsushi

AU - Styczynski, Jan

AU - Kovacs, Gabor

AU - Ottoffy, Gabor

AU - Felice, Maria S

AU - Buldini, Barbara

AU - Conter, Valentino

AU - Stary, Jan

AU - Schrappe, Martin

N1 - Copyright © 2020. Published by Elsevier Ltd.

PY - 2020/6

Y1 - 2020/6

N2 - INTRODUCTION: Since the beginning of COVID-19 pandemic, it is known that the severe course of the disease occurs mostly among the elderly, whereas it is rare among children and young adults. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Thus, there is concern that children treated for cancer may allso be at risk for an unfavourable course of infection. Along the same line, anecdotal information from Wuhan, China, mentioned a severe course of COVID-19 in a child treated for leukaemia.AIM AND METHODS: We made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short Web-based survey.RESULTS: We received reports from 25 countries, where approximately 10,000 patients at risk are followed up. At the time of the survey, more than 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease, and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19.CONCLUSION: Thus, even children receiving anticancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.

AB - INTRODUCTION: Since the beginning of COVID-19 pandemic, it is known that the severe course of the disease occurs mostly among the elderly, whereas it is rare among children and young adults. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Thus, there is concern that children treated for cancer may allso be at risk for an unfavourable course of infection. Along the same line, anecdotal information from Wuhan, China, mentioned a severe course of COVID-19 in a child treated for leukaemia.AIM AND METHODS: We made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short Web-based survey.RESULTS: We received reports from 25 countries, where approximately 10,000 patients at risk are followed up. At the time of the survey, more than 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease, and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19.CONCLUSION: Thus, even children receiving anticancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.

KW - Adolescent

KW - Antineoplastic Agents/therapeutic use

KW - Betacoronavirus

KW - COVID-19

KW - Child

KW - Coronavirus Infections/complications

KW - Female

KW - Humans

KW - Male

KW - Neoplasms/complications

KW - Pandemics

KW - Pneumonia, Viral/complications

KW - SARS-CoV-2

KW - Surveys and Questionnaires

U2 - 10.1016/j.ejca.2020.03.021

DO - 10.1016/j.ejca.2020.03.021

M3 - SCORING: Journal article

C2 - 32305831

VL - 132

SP - 11

EP - 16

JO - EUR J CANCER

JF - EUR J CANCER

SN - 0959-8049

ER -