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First North American validation and head-to-head comparison of four preoperative nomograms for prediction of lymph node invasion before radical prostatectomy

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First North American validation and head-to-head comparison of four preoperative nomograms for prediction of lymph node invasion before radical prostatectomy. / Bandini, Marco; Marchioni, Michele; Pompe, Raisa S; Tian, Zhe; Gandaglia, Giorgio; Fossati, Nicola; Abdollah, Firas; Graefen, Markus; Montorsi, Francesco; Saad, Fred; Shariat, Shahrokh F; Briganti, Alberto; Karakiewicz, Pierre I.

In: BJU INT, Vol. 121, No. 4, 04.2018, p. 592-599.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bandini, M, Marchioni, M, Pompe, RS, Tian, Z, Gandaglia, G, Fossati, N, Abdollah, F, Graefen, M, Montorsi, F, Saad, F, Shariat, SF, Briganti, A & Karakiewicz, PI 2018, 'First North American validation and head-to-head comparison of four preoperative nomograms for prediction of lymph node invasion before radical prostatectomy', BJU INT, vol. 121, no. 4, pp. 592-599. https://doi.org/10.1111/bju.14074

APA

Bandini, M., Marchioni, M., Pompe, R. S., Tian, Z., Gandaglia, G., Fossati, N., Abdollah, F., Graefen, M., Montorsi, F., Saad, F., Shariat, S. F., Briganti, A., & Karakiewicz, P. I. (2018). First North American validation and head-to-head comparison of four preoperative nomograms for prediction of lymph node invasion before radical prostatectomy. BJU INT, 121(4), 592-599. https://doi.org/10.1111/bju.14074

Vancouver

Bandini M, Marchioni M, Pompe RS, Tian Z, Gandaglia G, Fossati N et al. First North American validation and head-to-head comparison of four preoperative nomograms for prediction of lymph node invasion before radical prostatectomy. BJU INT. 2018 Apr;121(4):592-599. https://doi.org/10.1111/bju.14074

Bibtex

@article{7cbf1e585fa84263981b795ed879dc95,
title = "First North American validation and head-to-head comparison of four preoperative nomograms for prediction of lymph node invasion before radical prostatectomy",
abstract = "OBJECTIVES: To perform a head-to-head comparison of four nomograms; namely, the Cagiannos, the 2012-Briganti, the Godoy and the online-Memorial Sloan Kettering Cancer Center (MSKCC), for prediction of lymph node invasion (LNI) in a North American population.PATIENTS AND METHODS: A total of 19 775 patients with clinically localized prostate cancer (PCa) who had undergone radical prostatectomy and pelvic lymph node dissection (PLND) were identified within the Surveillance Epidemiology and End Results (SEER) database. All four nomograms were tested using Heagerty's concordance index (C-index), calibration plots and decision curve analysis (DCA). In addition, we examined specific nomogram-derived thresholds to compare the number of avoided PLNDs and missed LNI-positive cases.RESULTS: All nomograms were found to have highly comparable C-index values: the Cagiannos, 78.6%; the Godoy, 78.2%; the 2012-Briganti, 79.8%; and the MSKCC, 79.9%. The Cagiannos nomogram showed the best calibration, followed by the 2012-Briganti, the Godoy and the online-MSKCC. In DCA, the 2012-Briganti and the Cagiannos, in that order, provided the best results, followed by the Godoy and the online-MSKCC models. For each nomogram, the threshold associated with ≤10% missed LNI cases avoided 8 693 (46.6%), 8 652 (46.4%), 8 461 (45.4%) and 8 590 (46.1%) PLNDs, respectively, with the use of the Cagiannos (2.6% threshold), the online-MSKCC (4.3% threshold), the Godoy (3.6% threshold) and the 2012-Briganti (4.6% threshold) nomograms.CONCLUSION: The Cagiannos and the 2012-Briganti nomograms exhibited the best calibrations and DCA results. Conversely, C-index values and ability to avoid unnecessary PLNDs were virtually the same for all four nomograms examined.",
keywords = "Journal Article",
author = "Marco Bandini and Michele Marchioni and Pompe, {Raisa S} and Zhe Tian and Giorgio Gandaglia and Nicola Fossati and Firas Abdollah and Markus Graefen and Francesco Montorsi and Fred Saad and Shariat, {Shahrokh F} and Alberto Briganti and Karakiewicz, {Pierre I}",
note = "{\textcopyright} 2017 The Authors BJU International {\textcopyright} 2017 BJU International Published by John Wiley & Sons Ltd.",
year = "2018",
month = apr,
doi = "10.1111/bju.14074",
language = "English",
volume = "121",
pages = "592--599",
journal = "BJU INT",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - First North American validation and head-to-head comparison of four preoperative nomograms for prediction of lymph node invasion before radical prostatectomy

AU - Bandini, Marco

AU - Marchioni, Michele

AU - Pompe, Raisa S

AU - Tian, Zhe

AU - Gandaglia, Giorgio

AU - Fossati, Nicola

AU - Abdollah, Firas

AU - Graefen, Markus

AU - Montorsi, Francesco

AU - Saad, Fred

AU - Shariat, Shahrokh F

AU - Briganti, Alberto

AU - Karakiewicz, Pierre I

N1 - © 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd.

PY - 2018/4

Y1 - 2018/4

N2 - OBJECTIVES: To perform a head-to-head comparison of four nomograms; namely, the Cagiannos, the 2012-Briganti, the Godoy and the online-Memorial Sloan Kettering Cancer Center (MSKCC), for prediction of lymph node invasion (LNI) in a North American population.PATIENTS AND METHODS: A total of 19 775 patients with clinically localized prostate cancer (PCa) who had undergone radical prostatectomy and pelvic lymph node dissection (PLND) were identified within the Surveillance Epidemiology and End Results (SEER) database. All four nomograms were tested using Heagerty's concordance index (C-index), calibration plots and decision curve analysis (DCA). In addition, we examined specific nomogram-derived thresholds to compare the number of avoided PLNDs and missed LNI-positive cases.RESULTS: All nomograms were found to have highly comparable C-index values: the Cagiannos, 78.6%; the Godoy, 78.2%; the 2012-Briganti, 79.8%; and the MSKCC, 79.9%. The Cagiannos nomogram showed the best calibration, followed by the 2012-Briganti, the Godoy and the online-MSKCC. In DCA, the 2012-Briganti and the Cagiannos, in that order, provided the best results, followed by the Godoy and the online-MSKCC models. For each nomogram, the threshold associated with ≤10% missed LNI cases avoided 8 693 (46.6%), 8 652 (46.4%), 8 461 (45.4%) and 8 590 (46.1%) PLNDs, respectively, with the use of the Cagiannos (2.6% threshold), the online-MSKCC (4.3% threshold), the Godoy (3.6% threshold) and the 2012-Briganti (4.6% threshold) nomograms.CONCLUSION: The Cagiannos and the 2012-Briganti nomograms exhibited the best calibrations and DCA results. Conversely, C-index values and ability to avoid unnecessary PLNDs were virtually the same for all four nomograms examined.

AB - OBJECTIVES: To perform a head-to-head comparison of four nomograms; namely, the Cagiannos, the 2012-Briganti, the Godoy and the online-Memorial Sloan Kettering Cancer Center (MSKCC), for prediction of lymph node invasion (LNI) in a North American population.PATIENTS AND METHODS: A total of 19 775 patients with clinically localized prostate cancer (PCa) who had undergone radical prostatectomy and pelvic lymph node dissection (PLND) were identified within the Surveillance Epidemiology and End Results (SEER) database. All four nomograms were tested using Heagerty's concordance index (C-index), calibration plots and decision curve analysis (DCA). In addition, we examined specific nomogram-derived thresholds to compare the number of avoided PLNDs and missed LNI-positive cases.RESULTS: All nomograms were found to have highly comparable C-index values: the Cagiannos, 78.6%; the Godoy, 78.2%; the 2012-Briganti, 79.8%; and the MSKCC, 79.9%. The Cagiannos nomogram showed the best calibration, followed by the 2012-Briganti, the Godoy and the online-MSKCC. In DCA, the 2012-Briganti and the Cagiannos, in that order, provided the best results, followed by the Godoy and the online-MSKCC models. For each nomogram, the threshold associated with ≤10% missed LNI cases avoided 8 693 (46.6%), 8 652 (46.4%), 8 461 (45.4%) and 8 590 (46.1%) PLNDs, respectively, with the use of the Cagiannos (2.6% threshold), the online-MSKCC (4.3% threshold), the Godoy (3.6% threshold) and the 2012-Briganti (4.6% threshold) nomograms.CONCLUSION: The Cagiannos and the 2012-Briganti nomograms exhibited the best calibrations and DCA results. Conversely, C-index values and ability to avoid unnecessary PLNDs were virtually the same for all four nomograms examined.

KW - Journal Article

U2 - 10.1111/bju.14074

DO - 10.1111/bju.14074

M3 - SCORING: Journal article

C2 - 29124911

VL - 121

SP - 592

EP - 599

JO - BJU INT

JF - BJU INT

SN - 1464-4096

IS - 4

ER -