Research ExplorerPublicationsFirst experience with transcatheter aortic valve implantatio...

First experience with transcatheter aortic valve implantation and concomitant percutaneous coronary intervention

Standard

First experience with transcatheter aortic valve implantation and concomitant percutaneous coronary intervention. / Conradi, Lenard; Seiffert, Moritz; Franzen, Olaf; Baldus, Stephan; Schirmer, Johannes; Meinertz, Thomas; Reichenspurner, Hermann; Treede, Hendrik.

In: CLIN RES CARDIOL, Vol. 100, No. 4, 04.2011, p. 311-316.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Conradi, L, Seiffert, M, Franzen, O, Baldus, S, Schirmer, J, Meinertz, T, Reichenspurner, H & Treede, H 2011, 'First experience with transcatheter aortic valve implantation and concomitant percutaneous coronary intervention', CLIN RES CARDIOL, vol. 100, no. 4, pp. 311-316. https://doi.org/10.1007/s00392-010-0243-6

APA

Conradi, L., Seiffert, M., Franzen, O., Baldus, S., Schirmer, J., Meinertz, T., Reichenspurner, H., & Treede, H. (2011). First experience with transcatheter aortic valve implantation and concomitant percutaneous coronary intervention. CLIN RES CARDIOL, 100(4), 311-316. https://doi.org/10.1007/s00392-010-0243-6

Vancouver

Conradi L, Seiffert M, Franzen O, Baldus S, Schirmer J, Meinertz T et al. First experience with transcatheter aortic valve implantation and concomitant percutaneous coronary intervention. CLIN RES CARDIOL. 2011 Apr;100(4):311-316. https://doi.org/10.1007/s00392-010-0243-6

Bibtex

@article{7789acf9a0b242578725a18efd00dc84,
title = "First experience with transcatheter aortic valve implantation and concomitant percutaneous coronary intervention",
abstract = "OBJECTIVES: We investigated our experience with combined transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) as an alternative strategy in high-risk patients.BACKGROUND: Combined surgical aortic valve replacement and coronary artery bypass grafting are the gold standard treatment for patients with aortic stenosis and concomitant coronary artery disease. However, a substantial share of patients is unfit for surgery due to contraindications.METHODS: Twenty-eight patients (15 female) underwent combined TAVI and PCI after being refused for surgery. In 21 patients (group 1) a staged approach of PCI prior to subsequent TAVI was chosen. Seven patients (group 2) were treated in a single-stage procedure.RESULTS: Mean patient age was 80.1 ± 6.9 years, pre-procedural risk assessment revealed a mean logEuroSCORE of 26.8 ± 13.4%. Left ventricular ejection fraction was 45.6 ± 11.1%. Baseline mean/peak transvalvular gradients were 40.2 ± 16.8 and 65.6 ± 26.6 mmHg, respectively, and decreased to mean/peak values of 9.3 ± 4.2/15.2 ± 8.4 mmHg (p < 0.0001), effective orifice area increased from 0.73 ± 0.25 to 1.74 ± 0.47 cm(2) (p < 0.0001). In group 2, fluoroscopy time and amount of contrast agent were significantly higher compared to group 1 (18.1 ± 9.2 vs. 9.5 ± 7.0 min; p = 0.03/292.3 ± 117.5 vs. 171.9 ± 68.4 ml; p = 0.006). In group 1, patients received PCI 14.3 ± 9.6 days prior to TAVI. In group 2, PCI was performed immediately before TAVI. A mean of 1.6 ± 1.0 stents was placed per patient. No periprocedural myocardial infarction or stroke occurred in any patient. Thirty-day mortality was 7.1% (2/28).CONCLUSION: Our strategy of staged or single-stage TAVI and PCI proved feasible and safe in this high-risk patient population. Whether there is advantage of one approach over the other remains to be elucidated.",
keywords = "Aged, Aged, 80 and over, Angioplasty, Balloon, Coronary, Cardiac Catheterization, Combined Modality Therapy, Coronary Artery Disease/therapy, Female, Heart Valve Prosthesis Implantation, Humans, Male, Postoperative Complications, Risk Factors, Treatment Outcome",
author = "Lenard Conradi and Moritz Seiffert and Olaf Franzen and Stephan Baldus and Johannes Schirmer and Thomas Meinertz and Hermann Reichenspurner and Hendrik Treede",
year = "2011",
month = apr,
doi = "10.1007/s00392-010-0243-6",
language = "English",
volume = "100",
pages = "311--316",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "4",

}

RIS

TY - JOUR

T1 - First experience with transcatheter aortic valve implantation and concomitant percutaneous coronary intervention

AU - Conradi, Lenard

AU - Seiffert, Moritz

AU - Franzen, Olaf

AU - Baldus, Stephan

AU - Schirmer, Johannes

AU - Meinertz, Thomas

AU - Reichenspurner, Hermann

AU - Treede, Hendrik

PY - 2011/4

Y1 - 2011/4

N2 - OBJECTIVES: We investigated our experience with combined transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) as an alternative strategy in high-risk patients.BACKGROUND: Combined surgical aortic valve replacement and coronary artery bypass grafting are the gold standard treatment for patients with aortic stenosis and concomitant coronary artery disease. However, a substantial share of patients is unfit for surgery due to contraindications.METHODS: Twenty-eight patients (15 female) underwent combined TAVI and PCI after being refused for surgery. In 21 patients (group 1) a staged approach of PCI prior to subsequent TAVI was chosen. Seven patients (group 2) were treated in a single-stage procedure.RESULTS: Mean patient age was 80.1 ± 6.9 years, pre-procedural risk assessment revealed a mean logEuroSCORE of 26.8 ± 13.4%. Left ventricular ejection fraction was 45.6 ± 11.1%. Baseline mean/peak transvalvular gradients were 40.2 ± 16.8 and 65.6 ± 26.6 mmHg, respectively, and decreased to mean/peak values of 9.3 ± 4.2/15.2 ± 8.4 mmHg (p < 0.0001), effective orifice area increased from 0.73 ± 0.25 to 1.74 ± 0.47 cm(2) (p < 0.0001). In group 2, fluoroscopy time and amount of contrast agent were significantly higher compared to group 1 (18.1 ± 9.2 vs. 9.5 ± 7.0 min; p = 0.03/292.3 ± 117.5 vs. 171.9 ± 68.4 ml; p = 0.006). In group 1, patients received PCI 14.3 ± 9.6 days prior to TAVI. In group 2, PCI was performed immediately before TAVI. A mean of 1.6 ± 1.0 stents was placed per patient. No periprocedural myocardial infarction or stroke occurred in any patient. Thirty-day mortality was 7.1% (2/28).CONCLUSION: Our strategy of staged or single-stage TAVI and PCI proved feasible and safe in this high-risk patient population. Whether there is advantage of one approach over the other remains to be elucidated.

AB - OBJECTIVES: We investigated our experience with combined transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) as an alternative strategy in high-risk patients.BACKGROUND: Combined surgical aortic valve replacement and coronary artery bypass grafting are the gold standard treatment for patients with aortic stenosis and concomitant coronary artery disease. However, a substantial share of patients is unfit for surgery due to contraindications.METHODS: Twenty-eight patients (15 female) underwent combined TAVI and PCI after being refused for surgery. In 21 patients (group 1) a staged approach of PCI prior to subsequent TAVI was chosen. Seven patients (group 2) were treated in a single-stage procedure.RESULTS: Mean patient age was 80.1 ± 6.9 years, pre-procedural risk assessment revealed a mean logEuroSCORE of 26.8 ± 13.4%. Left ventricular ejection fraction was 45.6 ± 11.1%. Baseline mean/peak transvalvular gradients were 40.2 ± 16.8 and 65.6 ± 26.6 mmHg, respectively, and decreased to mean/peak values of 9.3 ± 4.2/15.2 ± 8.4 mmHg (p < 0.0001), effective orifice area increased from 0.73 ± 0.25 to 1.74 ± 0.47 cm(2) (p < 0.0001). In group 2, fluoroscopy time and amount of contrast agent were significantly higher compared to group 1 (18.1 ± 9.2 vs. 9.5 ± 7.0 min; p = 0.03/292.3 ± 117.5 vs. 171.9 ± 68.4 ml; p = 0.006). In group 1, patients received PCI 14.3 ± 9.6 days prior to TAVI. In group 2, PCI was performed immediately before TAVI. A mean of 1.6 ± 1.0 stents was placed per patient. No periprocedural myocardial infarction or stroke occurred in any patient. Thirty-day mortality was 7.1% (2/28).CONCLUSION: Our strategy of staged or single-stage TAVI and PCI proved feasible and safe in this high-risk patient population. Whether there is advantage of one approach over the other remains to be elucidated.

KW - Aged

KW - Aged, 80 and over

KW - Angioplasty, Balloon, Coronary

KW - Cardiac Catheterization

KW - Combined Modality Therapy

KW - Coronary Artery Disease/therapy

KW - Female

KW - Heart Valve Prosthesis Implantation

KW - Humans

KW - Male

KW - Postoperative Complications

KW - Risk Factors

KW - Treatment Outcome

U2 - 10.1007/s00392-010-0243-6

DO - 10.1007/s00392-010-0243-6

M3 - SCORING: Journal article

C2 - 20959999

VL - 100

SP - 311

EP - 316

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 4

ER -