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Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

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Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. / Dadaev, Tokhir; Saunders, Edward J; Newcombe, Paul J; Anokian, Ezequiel; Leongamornlert, Daniel A; Brook, Mark N; Cieza-Borrella, Clara; Mijuskovic, Martina; Wakerell, Sarah; Olama, Ali Amin Al; Schumacher, Fredrick R; Berndt, Sonja I; Benlloch, Sara; Ahmed, Mahbubl; Goh, Chee; Sheng, Xin; Zhang, Zhuo; Muir, Kenneth; Govindasami, Koveela; Lophatananon, Artitaya; Stevens, Victoria L; Gapstur, Susan M; Carter, Brian D; Tangen, Catherine M; Goodman, Phyllis; Thompson, Ian M; Batra, Jyotsna; Chambers, Suzanne; Moya, Leire; Clements, Judith; Horvath, Lisa; Tilley, Wayne; Risbridger, Gail; Gronberg, Henrik; Aly, Markus; Nordström, Tobias; Pharoah, Paul; Pashayan, Nora; Schleutker, Johanna; Tammela, Teuvo L J; Sipeky, Csilla; Auvinen, Anssi; Albanes, Demetrius; Weinstein, Stephanie; Wolk, Alicja; Hakansson, Niclas; West, Catharine; Dunning, Alison M; Burnet, Neil; Mucci, Lorelei; Giovannucci, Edward; Andriole, Gerald; Cussenot, Olivier; Cancel-Tassin, Géraldine; Koutros, Stella; Freeman, Laura E Beane; Sorensen, Karina Dalsgaard; Orntoft, Torben Falck; Borre, Michael; Maehle, Lovise; Grindedal, Eli Marie; Neal, David E; Donovan, Jenny L; Hamdy, Freddie C; Martin, Richard M; Travis, Ruth C; Key, Tim J; Hamilton, Robert J; Fleshner, Neil E; Finelli, Antonio; Ingles, Sue Ann; Stern, Mariana C; Rosenstein, Barry; Kerns, Sarah; Ostrer, Harry; Lu, Yong-Jie; Zhang, Hong-Wei; Feng, Ninghan; Mao, Xueying; Guo, Xin; Wang, Guomin; Sun, Zan; Giles, Graham G; Southey, Melissa C; MacInnis, Robert J; FitzGerald, Liesel M; Kibel, Adam S; Drake, Bettina F; Vega, Ana; Gómez-Caamaño, Antonio; Fachal, Laura; Szulkin, Robert; Eklund, Martin; Kogevinas, Manolis; Llorca, Javier; Castaño-Vinyals, Gemma; Penney, Kathryn L; Stampfer, Meir; Park, Jong Y; Sellers, Thomas A; Lin, Hui-Yi; Stanford, Janet L; Cybulski, Cezary; Wokolorczyk, Dominika; Lubinski, Jan; Ostrander, Elaine A; Geybels, Milan S; Nordestgaard, Børge G; Nielsen, Sune F; Weisher, Maren; Bisbjerg, Rasmus; Røder, Martin Andreas; Iversen, Peter; Brenner, Hermann; Cuk, Katarina; Holleczek, Bernd; Maier, Christiane; Luedeke, Manuel; Schnoeller, Thomas; Kim, Jeri; Logothetis, Christopher J; John, Esther M; Teixeira, Manuel R; Paulo, Paula; Cardoso, Marta; Neuhausen, Susan L; Steele, Linda; Ding, Yuan Chun; De Ruyck, Kim; De Meerleer, Gert; Ost, Piet; Razack, Azad; Lim, Jasmine; Teo, Soo-Hwang; Lin, Daniel W; Newcomb, Lisa F; Lessel, Davor; Gamulin, Marija; Kulis, Tomislav; Kaneva, Radka; Usmani, Nawaid; Slavov, Chavdar; Mitev, Vanio; Parliament, Matthew; Singhal, Sandeep; Claessens, Frank; Joniau, Steven; Van den Broeck, Thomas; Larkin, Samantha; Townsend, Paul A; Aukim-Hastie, Claire; Gago-Dominguez, Manuela; Castelao, Jose Esteban; Martinez, Maria Elena; Roobol, Monique J; Jenster, Guido; van Schaik, Ron H N; Menegaux, Florence; Truong, Thérèse; Koudou, Yves Akoli; Xu, Jianfeng; Khaw, Kay-Tee; Cannon-Albright, Lisa; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej; Thibodeau, Stephen N; McDonnell, Shannon K; Schaid, Daniel J; Lindstrom, Sara; Turman, Constance; Ma, Jing; Hunter, David J; Riboli, Elio; Siddiq, Afshan; Canzian, Federico; Kolonel, Laurence N; Le Marchand, Loic; Hoover, Robert N; Machiela, Mitchell J; Kraft, Peter; Freedman, Matthew; Wiklund, Fredrik; Chanock, Stephen; Henderson, Brian E; Easton, Douglas F; Haiman, Christopher A; Eeles, Rosalind A; Conti, David V; Kote-Jarai, Zsofia; PRACTICAL Consortium.

In: NAT COMMUN, Vol. 9, No. 1, 11.06.2018, p. 2256.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dadaev, T, Saunders, EJ, Newcombe, PJ, Anokian, E, Leongamornlert, DA, Brook, MN, Cieza-Borrella, C, Mijuskovic, M, Wakerell, S, Olama, AAA, Schumacher, FR, Berndt, SI, Benlloch, S, Ahmed, M, Goh, C, Sheng, X, Zhang, Z, Muir, K, Govindasami, K, Lophatananon, A, Stevens, VL, Gapstur, SM, Carter, BD, Tangen, CM, Goodman, P, Thompson, IM, Batra, J, Chambers, S, Moya, L, Clements, J, Horvath, L, Tilley, W, Risbridger, G, Gronberg, H, Aly, M, Nordström, T, Pharoah, P, Pashayan, N, Schleutker, J, Tammela, TLJ, Sipeky, C, Auvinen, A, Albanes, D, Weinstein, S, Wolk, A, Hakansson, N, West, C, Dunning, AM, Burnet, N, Mucci, L, Giovannucci, E, Andriole, G, Cussenot, O, Cancel-Tassin, G, Koutros, S, Freeman, LEB, Sorensen, KD, Orntoft, TF, Borre, M, Maehle, L, Grindedal, EM, Neal, DE, Donovan, JL, Hamdy, FC, Martin, RM, Travis, RC, Key, TJ, Hamilton, RJ, Fleshner, NE, Finelli, A, Ingles, SA, Stern, MC, Rosenstein, B, Kerns, S, Ostrer, H, Lu, Y-J, Zhang, H-W, Feng, N, Mao, X, Guo, X, Wang, G, Sun, Z, Giles, GG, Southey, MC, MacInnis, RJ, FitzGerald, LM, Kibel, AS, Drake, BF, Vega, A, Gómez-Caamaño, A, Fachal, L, Szulkin, R, Eklund, M, Kogevinas, M, Llorca, J, Castaño-Vinyals, G, Penney, KL, Stampfer, M, Park, JY, Sellers, TA, Lin, H-Y, Stanford, JL, Cybulski, C, Wokolorczyk, D, Lubinski, J, Ostrander, EA, Geybels, MS, Nordestgaard, BG, Nielsen, SF, Weisher, M, Bisbjerg, R, Røder, MA, Iversen, P, Brenner, H, Cuk, K, Holleczek, B, Maier, C, Luedeke, M, Schnoeller, T, Kim, J, Logothetis, CJ, John, EM, Teixeira, MR, Paulo, P, Cardoso, M, Neuhausen, SL, Steele, L, Ding, YC, De Ruyck, K, De Meerleer, G, Ost, P, Razack, A, Lim, J, Teo, S-H, Lin, DW, Newcomb, LF, Lessel, D, Gamulin, M, Kulis, T, Kaneva, R, Usmani, N, Slavov, C, Mitev, V, Parliament, M, Singhal, S, Claessens, F, Joniau, S, Van den Broeck, T, Larkin, S, Townsend, PA, Aukim-Hastie, C, Gago-Dominguez, M, Castelao, JE, Martinez, ME, Roobol, MJ, Jenster, G, van Schaik, RHN, Menegaux, F, Truong, T, Koudou, YA, Xu, J, Khaw, K-T, Cannon-Albright, L, Pandha, H, Michael, A, Kierzek, A, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Lindstrom, S, Turman, C, Ma, J, Hunter, DJ, Riboli, E, Siddiq, A, Canzian, F, Kolonel, LN, Le Marchand, L, Hoover, RN, Machiela, MJ, Kraft, P, Freedman, M, Wiklund, F, Chanock, S, Henderson, BE, Easton, DF, Haiman, CA, Eeles, RA, Conti, DV, Kote-Jarai, Z & PRACTICAL Consortium 2018, 'Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants', NAT COMMUN, vol. 9, no. 1, pp. 2256. https://doi.org/10.1038/s41467-018-04109-8

APA

Dadaev, T., Saunders, E. J., Newcombe, P. J., Anokian, E., Leongamornlert, D. A., Brook, M. N., Cieza-Borrella, C., Mijuskovic, M., Wakerell, S., Olama, A. A. A., Schumacher, F. R., Berndt, S. I., Benlloch, S., Ahmed, M., Goh, C., Sheng, X., Zhang, Z., Muir, K., Govindasami, K., ... PRACTICAL Consortium (2018). Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. NAT COMMUN, 9(1), 2256. https://doi.org/10.1038/s41467-018-04109-8

Vancouver

Dadaev T, Saunders EJ, Newcombe PJ, Anokian E, Leongamornlert DA, Brook MN et al. Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. NAT COMMUN. 2018 Jun 11;9(1):2256. https://doi.org/10.1038/s41467-018-04109-8

Bibtex

@article{e44f6faa3b2f4bb5a176ac33d1fbee96,
title = "Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants",
abstract = "Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.",
keywords = "Journal Article",
author = "Tokhir Dadaev and Saunders, {Edward J} and Newcombe, {Paul J} and Ezequiel Anokian and Leongamornlert, {Daniel A} and Brook, {Mark N} and Clara Cieza-Borrella and Martina Mijuskovic and Sarah Wakerell and Olama, {Ali Amin Al} and Schumacher, {Fredrick R} and Berndt, {Sonja I} and Sara Benlloch and Mahbubl Ahmed and Chee Goh and Xin Sheng and Zhuo Zhang and Kenneth Muir and Koveela Govindasami and Artitaya Lophatananon and Stevens, {Victoria L} and Gapstur, {Susan M} and Carter, {Brian D} and Tangen, {Catherine M} and Phyllis Goodman and Thompson, {Ian M} and Jyotsna Batra and Suzanne Chambers and Leire Moya and Judith Clements and Lisa Horvath and Wayne Tilley and Gail Risbridger and Henrik Gronberg and Markus Aly and Tobias Nordstr{\"o}m and Paul Pharoah and Nora Pashayan and Johanna Schleutker and Tammela, {Teuvo L J} and Csilla Sipeky and Anssi Auvinen and Demetrius Albanes and Stephanie Weinstein and Alicja Wolk and Niclas Hakansson and Catharine West and Dunning, {Alison M} and Neil Burnet and Lorelei Mucci and Edward Giovannucci and Gerald Andriole and Olivier Cussenot and G{\'e}raldine Cancel-Tassin and Stella Koutros and Freeman, {Laura E Beane} and Sorensen, {Karina Dalsgaard} and Orntoft, {Torben Falck} and Michael Borre and Lovise Maehle and Grindedal, {Eli Marie} and Neal, {David E} and Donovan, {Jenny L} and Hamdy, {Freddie C} and Martin, {Richard M} and Travis, {Ruth C} and Key, {Tim J} and Hamilton, {Robert J} and Fleshner, {Neil E} and Antonio Finelli and Ingles, {Sue Ann} and Stern, {Mariana C} and Barry Rosenstein and Sarah Kerns and Harry Ostrer and Yong-Jie Lu and Hong-Wei Zhang and Ninghan Feng and Xueying Mao and Xin Guo and Guomin Wang and Zan Sun and Giles, {Graham G} and Southey, {Melissa C} and MacInnis, {Robert J} and FitzGerald, {Liesel M} and Kibel, {Adam S} and Drake, {Bettina F} and Ana Vega and Antonio G{\'o}mez-Caama{\~n}o and Laura Fachal and Robert Szulkin and Martin Eklund and Manolis Kogevinas and Javier Llorca and Gemma Casta{\~n}o-Vinyals and Penney, {Kathryn L} and Meir Stampfer and Park, {Jong Y} and Sellers, {Thomas A} and Hui-Yi Lin and Stanford, {Janet L} and Cezary Cybulski and Dominika Wokolorczyk and Jan Lubinski and Ostrander, {Elaine A} and Geybels, {Milan S} and Nordestgaard, {B{\o}rge G} and Nielsen, {Sune F} and Maren Weisher and Rasmus Bisbjerg and R{\o}der, {Martin Andreas} and Peter Iversen and Hermann Brenner and Katarina Cuk and Bernd Holleczek and Christiane Maier and Manuel Luedeke and Thomas Schnoeller and Jeri Kim and Logothetis, {Christopher J} and John, {Esther M} and Teixeira, {Manuel R} and Paula Paulo and Marta Cardoso and Neuhausen, {Susan L} and Linda Steele and Ding, {Yuan Chun} and {De Ruyck}, Kim and {De Meerleer}, Gert and Piet Ost and Azad Razack and Jasmine Lim and Soo-Hwang Teo and Lin, {Daniel W} and Newcomb, {Lisa F} and Davor Lessel and Marija Gamulin and Tomislav Kulis and Radka Kaneva and Nawaid Usmani and Chavdar Slavov and Vanio Mitev and Matthew Parliament and Sandeep Singhal and Frank Claessens and Steven Joniau and {Van den Broeck}, Thomas and Samantha Larkin and Townsend, {Paul A} and Claire Aukim-Hastie and Manuela Gago-Dominguez and Castelao, {Jose Esteban} and Martinez, {Maria Elena} and Roobol, {Monique J} and Guido Jenster and {van Schaik}, {Ron H N} and Florence Menegaux and Th{\'e}r{\`e}se Truong and Koudou, {Yves Akoli} and Jianfeng Xu and Kay-Tee Khaw and Lisa Cannon-Albright and Hardev Pandha and Agnieszka Michael and Andrzej Kierzek and Thibodeau, {Stephen N} and McDonnell, {Shannon K} and Schaid, {Daniel J} and Sara Lindstrom and Constance Turman and Jing Ma and Hunter, {David J} and Elio Riboli and Afshan Siddiq and Federico Canzian and Kolonel, {Laurence N} and {Le Marchand}, Loic and Hoover, {Robert N} and Machiela, {Mitchell J} and Peter Kraft and Matthew Freedman and Fredrik Wiklund and Stephen Chanock and Henderson, {Brian E} and Easton, {Douglas F} and Haiman, {Christopher A} and Eeles, {Rosalind A} and Conti, {David V} and Zsofia Kote-Jarai and {PRACTICAL Consortium}",
year = "2018",
month = jun,
day = "11",
doi = "10.1038/s41467-018-04109-8",
language = "English",
volume = "9",
pages = "2256",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

AU - Dadaev, Tokhir

AU - Saunders, Edward J

AU - Newcombe, Paul J

AU - Anokian, Ezequiel

AU - Leongamornlert, Daniel A

AU - Brook, Mark N

AU - Cieza-Borrella, Clara

AU - Mijuskovic, Martina

AU - Wakerell, Sarah

AU - Olama, Ali Amin Al

AU - Schumacher, Fredrick R

AU - Berndt, Sonja I

AU - Benlloch, Sara

AU - Ahmed, Mahbubl

AU - Goh, Chee

AU - Sheng, Xin

AU - Zhang, Zhuo

AU - Muir, Kenneth

AU - Govindasami, Koveela

AU - Lophatananon, Artitaya

AU - Stevens, Victoria L

AU - Gapstur, Susan M

AU - Carter, Brian D

AU - Tangen, Catherine M

AU - Goodman, Phyllis

AU - Thompson, Ian M

AU - Batra, Jyotsna

AU - Chambers, Suzanne

AU - Moya, Leire

AU - Clements, Judith

AU - Horvath, Lisa

AU - Tilley, Wayne

AU - Risbridger, Gail

AU - Gronberg, Henrik

AU - Aly, Markus

AU - Nordström, Tobias

AU - Pharoah, Paul

AU - Pashayan, Nora

AU - Schleutker, Johanna

AU - Tammela, Teuvo L J

AU - Sipeky, Csilla

AU - Auvinen, Anssi

AU - Albanes, Demetrius

AU - Weinstein, Stephanie

AU - Wolk, Alicja

AU - Hakansson, Niclas

AU - West, Catharine

AU - Dunning, Alison M

AU - Burnet, Neil

AU - Mucci, Lorelei

AU - Giovannucci, Edward

AU - Andriole, Gerald

AU - Cussenot, Olivier

AU - Cancel-Tassin, Géraldine

AU - Koutros, Stella

AU - Freeman, Laura E Beane

AU - Sorensen, Karina Dalsgaard

AU - Orntoft, Torben Falck

AU - Borre, Michael

AU - Maehle, Lovise

AU - Grindedal, Eli Marie

AU - Neal, David E

AU - Donovan, Jenny L

AU - Hamdy, Freddie C

AU - Martin, Richard M

AU - Travis, Ruth C

AU - Key, Tim J

AU - Hamilton, Robert J

AU - Fleshner, Neil E

AU - Finelli, Antonio

AU - Ingles, Sue Ann

AU - Stern, Mariana C

AU - Rosenstein, Barry

AU - Kerns, Sarah

AU - Ostrer, Harry

AU - Lu, Yong-Jie

AU - Zhang, Hong-Wei

AU - Feng, Ninghan

AU - Mao, Xueying

AU - Guo, Xin

AU - Wang, Guomin

AU - Sun, Zan

AU - Giles, Graham G

AU - Southey, Melissa C

AU - MacInnis, Robert J

AU - FitzGerald, Liesel M

AU - Kibel, Adam S

AU - Drake, Bettina F

AU - Vega, Ana

AU - Gómez-Caamaño, Antonio

AU - Fachal, Laura

AU - Szulkin, Robert

AU - Eklund, Martin

AU - Kogevinas, Manolis

AU - Llorca, Javier

AU - Castaño-Vinyals, Gemma

AU - Penney, Kathryn L

AU - Stampfer, Meir

AU - Park, Jong Y

AU - Sellers, Thomas A

AU - Lin, Hui-Yi

AU - Stanford, Janet L

AU - Cybulski, Cezary

AU - Wokolorczyk, Dominika

AU - Lubinski, Jan

AU - Ostrander, Elaine A

AU - Geybels, Milan S

AU - Nordestgaard, Børge G

AU - Nielsen, Sune F

AU - Weisher, Maren

AU - Bisbjerg, Rasmus

AU - Røder, Martin Andreas

AU - Iversen, Peter

AU - Brenner, Hermann

AU - Cuk, Katarina

AU - Holleczek, Bernd

AU - Maier, Christiane

AU - Luedeke, Manuel

AU - Schnoeller, Thomas

AU - Kim, Jeri

AU - Logothetis, Christopher J

AU - John, Esther M

AU - Teixeira, Manuel R

AU - Paulo, Paula

AU - Cardoso, Marta

AU - Neuhausen, Susan L

AU - Steele, Linda

AU - Ding, Yuan Chun

AU - De Ruyck, Kim

AU - De Meerleer, Gert

AU - Ost, Piet

AU - Razack, Azad

AU - Lim, Jasmine

AU - Teo, Soo-Hwang

AU - Lin, Daniel W

AU - Newcomb, Lisa F

AU - Lessel, Davor

AU - Gamulin, Marija

AU - Kulis, Tomislav

AU - Kaneva, Radka

AU - Usmani, Nawaid

AU - Slavov, Chavdar

AU - Mitev, Vanio

AU - Parliament, Matthew

AU - Singhal, Sandeep

AU - Claessens, Frank

AU - Joniau, Steven

AU - Van den Broeck, Thomas

AU - Larkin, Samantha

AU - Townsend, Paul A

AU - Aukim-Hastie, Claire

AU - Gago-Dominguez, Manuela

AU - Castelao, Jose Esteban

AU - Martinez, Maria Elena

AU - Roobol, Monique J

AU - Jenster, Guido

AU - van Schaik, Ron H N

AU - Menegaux, Florence

AU - Truong, Thérèse

AU - Koudou, Yves Akoli

AU - Xu, Jianfeng

AU - Khaw, Kay-Tee

AU - Cannon-Albright, Lisa

AU - Pandha, Hardev

AU - Michael, Agnieszka

AU - Kierzek, Andrzej

AU - Thibodeau, Stephen N

AU - McDonnell, Shannon K

AU - Schaid, Daniel J

AU - Lindstrom, Sara

AU - Turman, Constance

AU - Ma, Jing

AU - Hunter, David J

AU - Riboli, Elio

AU - Siddiq, Afshan

AU - Canzian, Federico

AU - Kolonel, Laurence N

AU - Le Marchand, Loic

AU - Hoover, Robert N

AU - Machiela, Mitchell J

AU - Kraft, Peter

AU - Freedman, Matthew

AU - Wiklund, Fredrik

AU - Chanock, Stephen

AU - Henderson, Brian E

AU - Easton, Douglas F

AU - Haiman, Christopher A

AU - Eeles, Rosalind A

AU - Conti, David V

AU - Kote-Jarai, Zsofia

AU - PRACTICAL Consortium

PY - 2018/6/11

Y1 - 2018/6/11

N2 - Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.

AB - Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.

KW - Journal Article

U2 - 10.1038/s41467-018-04109-8

DO - 10.1038/s41467-018-04109-8

M3 - SCORING: Journal article

C2 - 29892050

VL - 9

SP - 2256

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -