Fiber-type transitions and satellite cell activation in low-frequency-stimulated muscles of young and aging rats.
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Fiber-type transitions and satellite cell activation in low-frequency-stimulated muscles of young and aging rats. / Putman, C T; Sultan, Karim; Wassmer, T; Bamford, J A; Skorjanc, D; Pette, D.
In: J GERONTOL A-BIOL, Vol. 56, No. 12, 12, 2001, p. 510-519.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Fiber-type transitions and satellite cell activation in low-frequency-stimulated muscles of young and aging rats.
AU - Putman, C T
AU - Sultan, Karim
AU - Wassmer, T
AU - Bamford, J A
AU - Skorjanc, D
AU - Pette, D
PY - 2001
Y1 - 2001
N2 - We examined satellite cell content and the activity of satellite cell progeny in tibialis anterior muscles of young (15 weeks) and aging (101 weeks) Brown Norway (BN) rats, after they were exposed for 50 days to a standardized and highly reproducible regime of chronic low-frequency electrical stimulation. Chronic low-frequency electrical stimulation was successful in inducing fast-to-slow fiber-type transformation, characterized by a 2.3-fold increase in the proportion of IIA fibers and fourfold and sevenfold decreases in the proportion of IID/X and IIB fibers in both young and aging BN rats. These changes were accompanied by a twofold increase in the satellite cell content in both the young and aging groups; satellite cell content reached a level that was significantly higher in the young group (p
AB - We examined satellite cell content and the activity of satellite cell progeny in tibialis anterior muscles of young (15 weeks) and aging (101 weeks) Brown Norway (BN) rats, after they were exposed for 50 days to a standardized and highly reproducible regime of chronic low-frequency electrical stimulation. Chronic low-frequency electrical stimulation was successful in inducing fast-to-slow fiber-type transformation, characterized by a 2.3-fold increase in the proportion of IIA fibers and fourfold and sevenfold decreases in the proportion of IID/X and IIB fibers in both young and aging BN rats. These changes were accompanied by a twofold increase in the satellite cell content in both the young and aging groups; satellite cell content reached a level that was significantly higher in the young group (p
M3 - SCORING: Zeitschriftenaufsatz
VL - 56
SP - 510
EP - 519
JO - J GERONTOL A-BIOL
JF - J GERONTOL A-BIOL
SN - 1079-5006
IS - 12
M1 - 12
ER -