Research ExplorerPublicationsFGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotei...

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues

Standard

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues. / Schlein, Christian; Talukdar, Saswata; Heine, Markus; Fischer, Alexander W; Krott, Lucia M; Nilsson, Stefan K; Brenner, Martin B; Heeren, Joerg; Scheja, Ludger.

In: CELL METAB, Vol. 23, No. 3, 08.03.2016, p. 441-53.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schlein, C, Talukdar, S, Heine, M, Fischer, AW, Krott, LM, Nilsson, SK, Brenner, MB, Heeren, J & Scheja, L 2016, 'FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues', CELL METAB, vol. 23, no. 3, pp. 441-53. https://doi.org/10.1016/j.cmet.2016.01.006

APA

Schlein, C., Talukdar, S., Heine, M., Fischer, A. W., Krott, L. M., Nilsson, S. K., Brenner, M. B., Heeren, J., & Scheja, L. (2016). FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues. CELL METAB, 23(3), 441-53. https://doi.org/10.1016/j.cmet.2016.01.006

Vancouver

Schlein C, Talukdar S, Heine M, Fischer AW, Krott LM, Nilsson SK et al. FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues. CELL METAB. 2016 Mar 8;23(3):441-53. https://doi.org/10.1016/j.cmet.2016.01.006

Bibtex

@article{161288eb05c0401caef8f6c3e37273a4,
title = "FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues",
abstract = "FGF21 decreases plasma triglycerides (TGs) in rodents and humans; however, the underlying mechanism or mechanisms are unclear. In the present study, we examined the role of FGF21 in production and disposal of TG-rich lipoproteins (TRLs) in mice. Treatment with pharmacological doses of FGF21 acutely reduced plasma non-esterified fatty acids (NEFAs), liver TG content, and VLDL-TG secretion. In addition, metabolic turnover studies revealed that FGF21 facilitated the catabolism of TRL in white adipose tissue (WAT) and brown adipose tissue (BAT). FGF21-dependent TRL processing was strongly attenuated in CD36-deficient mice and transgenic mice lacking lipoprotein lipase in adipose tissues. Insulin resistance in diet-induced obese and ob/ob mice shifted FGF21 responses from WAT toward energy-combusting BAT. In conclusion, FGF21 lowers plasma TGs through a dual mechanism: first, by reducing NEFA plasma levels and consequently hepatic VLDL lipidation and, second, by increasing CD36 and LPL-dependent TRL disposal in WAT and BAT.",
keywords = "Journal Article, Research Support, Non-U.S. Gov't, POM-Newsletter",
author = "Christian Schlein and Saswata Talukdar and Markus Heine and Fischer, {Alexander W} and Krott, {Lucia M} and Nilsson, {Stefan K} and Brenner, {Martin B} and Joerg Heeren and Ludger Scheja",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = mar,
day = "8",
doi = "10.1016/j.cmet.2016.01.006",
language = "English",
volume = "23",
pages = "441--53",
journal = "CELL METAB",
issn = "1550-4131",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues

AU - Schlein, Christian

AU - Talukdar, Saswata

AU - Heine, Markus

AU - Fischer, Alexander W

AU - Krott, Lucia M

AU - Nilsson, Stefan K

AU - Brenner, Martin B

AU - Heeren, Joerg

AU - Scheja, Ludger

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/3/8

Y1 - 2016/3/8

N2 - FGF21 decreases plasma triglycerides (TGs) in rodents and humans; however, the underlying mechanism or mechanisms are unclear. In the present study, we examined the role of FGF21 in production and disposal of TG-rich lipoproteins (TRLs) in mice. Treatment with pharmacological doses of FGF21 acutely reduced plasma non-esterified fatty acids (NEFAs), liver TG content, and VLDL-TG secretion. In addition, metabolic turnover studies revealed that FGF21 facilitated the catabolism of TRL in white adipose tissue (WAT) and brown adipose tissue (BAT). FGF21-dependent TRL processing was strongly attenuated in CD36-deficient mice and transgenic mice lacking lipoprotein lipase in adipose tissues. Insulin resistance in diet-induced obese and ob/ob mice shifted FGF21 responses from WAT toward energy-combusting BAT. In conclusion, FGF21 lowers plasma TGs through a dual mechanism: first, by reducing NEFA plasma levels and consequently hepatic VLDL lipidation and, second, by increasing CD36 and LPL-dependent TRL disposal in WAT and BAT.

AB - FGF21 decreases plasma triglycerides (TGs) in rodents and humans; however, the underlying mechanism or mechanisms are unclear. In the present study, we examined the role of FGF21 in production and disposal of TG-rich lipoproteins (TRLs) in mice. Treatment with pharmacological doses of FGF21 acutely reduced plasma non-esterified fatty acids (NEFAs), liver TG content, and VLDL-TG secretion. In addition, metabolic turnover studies revealed that FGF21 facilitated the catabolism of TRL in white adipose tissue (WAT) and brown adipose tissue (BAT). FGF21-dependent TRL processing was strongly attenuated in CD36-deficient mice and transgenic mice lacking lipoprotein lipase in adipose tissues. Insulin resistance in diet-induced obese and ob/ob mice shifted FGF21 responses from WAT toward energy-combusting BAT. In conclusion, FGF21 lowers plasma TGs through a dual mechanism: first, by reducing NEFA plasma levels and consequently hepatic VLDL lipidation and, second, by increasing CD36 and LPL-dependent TRL disposal in WAT and BAT.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - POM-Newsletter

U2 - 10.1016/j.cmet.2016.01.006

DO - 10.1016/j.cmet.2016.01.006

M3 - SCORING: Journal article

C2 - 26853749

VL - 23

SP - 441

EP - 453

JO - CELL METAB

JF - CELL METAB

SN - 1550-4131

IS - 3

ER -