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Fetomaternal immune cross-talk and its consequences for maternal and offspring's health.

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Fetomaternal immune cross-talk and its consequences for maternal and offspring's health. / Arck, Petra C; Hecher, Kurt.

In: NAT MED, Vol. 19, No. 5, 5, 2013, p. 548-556.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Arck, PC & Hecher, K 2013, 'Fetomaternal immune cross-talk and its consequences for maternal and offspring's health.', NAT MED, vol. 19, no. 5, 5, pp. 548-556. https://doi.org/10.1038/nm.3160

APA

Arck, P. C., & Hecher, K. (2013). Fetomaternal immune cross-talk and its consequences for maternal and offspring's health. NAT MED, 19(5), 548-556. [5]. https://doi.org/10.1038/nm.3160

Vancouver

Arck PC, Hecher K. Fetomaternal immune cross-talk and its consequences for maternal and offspring's health. NAT MED. 2013;19(5):548-556. 5. https://doi.org/10.1038/nm.3160

Bibtex

@article{71af2cb4fc8a40e2a1f1ad8aa073e0b7,
title = "Fetomaternal immune cross-talk and its consequences for maternal and offspring's health.",
abstract = "An improved mechanistic understanding of the adaptational processes mounted during mammalian reproduction is emerging. Intricate pathways occurring at the fetomaternal interface, such as the formation of a functional synapse between invading fetal trophoblast cells, and the involvement of various maternal immune cell subsets and epigenetically modified decidual stromal cells have now been identified. These complex pathways synergistically create a tolerogenic niche in which the semiallogeneic fetus can develop. New insights into fetomaternal immune cross-talk may help us to understand the pathogenesis of pregnancy complications as well as poor postnatal health. Moreover, the effects of maternal immune adaptation to pregnancy on autoimmune disease activity are becoming increasingly evident. Thus, insights into fetomaternal immune cross-talk not only advance our understanding of pregnancy-related complications but also may be informative on how immune tolerance can be modulated in clinical settings outside the context of reproduction.",
keywords = "Animals, Humans, Female, Mice, Pregnancy, Epigenesis, Genetic, Immune Tolerance/immunology, Decidua/immunology, Fetus/immunology, Maternal-Fetal Exchange/*immunology, Pregnancy Complications, Reproduction/*physiology, Stromal Cells/*cytology, Trophoblasts/immunology, Animals, Humans, Female, Mice, Pregnancy, Epigenesis, Genetic, Immune Tolerance/immunology, Decidua/immunology, Fetus/immunology, Maternal-Fetal Exchange/*immunology, Pregnancy Complications, Reproduction/*physiology, Stromal Cells/*cytology, Trophoblasts/immunology",
author = "Arck, {Petra C} and Kurt Hecher",
year = "2013",
doi = "10.1038/nm.3160",
language = "English",
volume = "19",
pages = "548--556",
journal = "NAT MED",
issn = "1078-8956",
publisher = "NATURE PUBLISHING GROUP",
number = "5",

}

RIS

TY - JOUR

T1 - Fetomaternal immune cross-talk and its consequences for maternal and offspring's health.

AU - Arck, Petra C

AU - Hecher, Kurt

PY - 2013

Y1 - 2013

N2 - An improved mechanistic understanding of the adaptational processes mounted during mammalian reproduction is emerging. Intricate pathways occurring at the fetomaternal interface, such as the formation of a functional synapse between invading fetal trophoblast cells, and the involvement of various maternal immune cell subsets and epigenetically modified decidual stromal cells have now been identified. These complex pathways synergistically create a tolerogenic niche in which the semiallogeneic fetus can develop. New insights into fetomaternal immune cross-talk may help us to understand the pathogenesis of pregnancy complications as well as poor postnatal health. Moreover, the effects of maternal immune adaptation to pregnancy on autoimmune disease activity are becoming increasingly evident. Thus, insights into fetomaternal immune cross-talk not only advance our understanding of pregnancy-related complications but also may be informative on how immune tolerance can be modulated in clinical settings outside the context of reproduction.

AB - An improved mechanistic understanding of the adaptational processes mounted during mammalian reproduction is emerging. Intricate pathways occurring at the fetomaternal interface, such as the formation of a functional synapse between invading fetal trophoblast cells, and the involvement of various maternal immune cell subsets and epigenetically modified decidual stromal cells have now been identified. These complex pathways synergistically create a tolerogenic niche in which the semiallogeneic fetus can develop. New insights into fetomaternal immune cross-talk may help us to understand the pathogenesis of pregnancy complications as well as poor postnatal health. Moreover, the effects of maternal immune adaptation to pregnancy on autoimmune disease activity are becoming increasingly evident. Thus, insights into fetomaternal immune cross-talk not only advance our understanding of pregnancy-related complications but also may be informative on how immune tolerance can be modulated in clinical settings outside the context of reproduction.

KW - Animals

KW - Humans

KW - Female

KW - Mice

KW - Pregnancy

KW - Epigenesis, Genetic

KW - Immune Tolerance/immunology

KW - Decidua/immunology

KW - Fetus/immunology

KW - Maternal-Fetal Exchange/immunology

KW - Pregnancy Complications

KW - Reproduction/physiology

KW - Stromal Cells/cytology

KW - Trophoblasts/immunology

KW - Animals

KW - Humans

KW - Female

KW - Mice

KW - Pregnancy

KW - Epigenesis, Genetic

KW - Immune Tolerance/immunology

KW - Decidua/immunology

KW - Fetus/immunology

KW - Maternal-Fetal Exchange/immunology

KW - Pregnancy Complications

KW - Reproduction/physiology

KW - Stromal Cells/cytology

KW - Trophoblasts/immunology

U2 - 10.1038/nm.3160

DO - 10.1038/nm.3160

M3 - SCORING: Journal article

C2 - 23652115

VL - 19

SP - 548

EP - 556

JO - NAT MED

JF - NAT MED

SN - 1078-8956

IS - 5

M1 - 5

ER -