Feasibility of assessing utilities with a single-item standard gamble questionnaire in patients with melanoma
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Feasibility of assessing utilities with a single-item standard gamble questionnaire in patients with melanoma. / Blome, Christine; Kähler, Katharina C; Wagner, Tobias; Hauschild, Axel; Augustin, Matthias.
In: J PATIENT-REP OUTCOM, Vol. 5, No. 1, 78, 28.08.2021.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Feasibility of assessing utilities with a single-item standard gamble questionnaire in patients with melanoma
AU - Blome, Christine
AU - Kähler, Katharina C
AU - Wagner, Tobias
AU - Hauschild, Axel
AU - Augustin, Matthias
N1 - © 2021. The Author(s).
PY - 2021/8/28
Y1 - 2021/8/28
N2 - OBJECTIVES: To determine the feasibility of eliciting utilities with a standard gamble self-completion questionnaire that uses a single-item approach in melanoma patients.METHODS: 150 patients with low-risk melanoma completed a paper standard gamble questionnaire. Six scenarios described the adjuvant treatment of high-risk melanoma with interferon alfa-2b with varied side effects. Patients were asked to directly state the maximum death risk they would accept to prevent these health states. Methods were the same as in a study by Kilbridge et al. (J Clin Oncol 19(3):812-823, 2021. https://doi.org/10.1200/JCO.2001.19.3.812 ), except that they used computerised interviews and an iterative risk variation (Ping-Pong method) to elicit utilities.RESULTS: The rate of missing values in the standard gamble was 1.0%. The percentage of patients who misordered scenarios was very similar to the reference study (11.3% vs. 11.2%). Mean utilities were also similar with a maximum difference of 0.02 points, but median utilities were not (between 0.21 points below and 0.05 points above the reference study).CONCLUSIONS: One-item utility elicitation with questionnaires might be a feasible alternative to computerised face-to-face interviews to conduct a standard gamble in melanoma patients.
AB - OBJECTIVES: To determine the feasibility of eliciting utilities with a standard gamble self-completion questionnaire that uses a single-item approach in melanoma patients.METHODS: 150 patients with low-risk melanoma completed a paper standard gamble questionnaire. Six scenarios described the adjuvant treatment of high-risk melanoma with interferon alfa-2b with varied side effects. Patients were asked to directly state the maximum death risk they would accept to prevent these health states. Methods were the same as in a study by Kilbridge et al. (J Clin Oncol 19(3):812-823, 2021. https://doi.org/10.1200/JCO.2001.19.3.812 ), except that they used computerised interviews and an iterative risk variation (Ping-Pong method) to elicit utilities.RESULTS: The rate of missing values in the standard gamble was 1.0%. The percentage of patients who misordered scenarios was very similar to the reference study (11.3% vs. 11.2%). Mean utilities were also similar with a maximum difference of 0.02 points, but median utilities were not (between 0.21 points below and 0.05 points above the reference study).CONCLUSIONS: One-item utility elicitation with questionnaires might be a feasible alternative to computerised face-to-face interviews to conduct a standard gamble in melanoma patients.
U2 - 10.1186/s41687-021-00350-w
DO - 10.1186/s41687-021-00350-w
M3 - SCORING: Journal article
C2 - 34453625
VL - 5
JO - J PATIENT-REP OUTCOM
JF - J PATIENT-REP OUTCOM
SN - 2509-8020
IS - 1
M1 - 78
ER -
