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FDG Uptake in the Basal Forebrain as Measured by Digital High-Resolution PET Is a Promising Marker of Basal Forebrain Degeneration in the Lewy Body Disease Spectrum: A Pilot Study

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FDG Uptake in the Basal Forebrain as Measured by Digital High-Resolution PET Is a Promising Marker of Basal Forebrain Degeneration in the Lewy Body Disease Spectrum: A Pilot Study. / Özden, Cansu; Frings, Lars; Apostolova, Ivayla; Lange, Catharina; Klutmann, Susanne; Adam, Gerhard; Bannas, Peter; Meyer, Philipp T; Grothe, Michel J; Buchert, Ralph.

In: CLIN NUCL MED, Vol. 45, No. 4, 04.2020, p. 261-266.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Özden, C, Frings, L, Apostolova, I, Lange, C, Klutmann, S, Adam, G, Bannas, P, Meyer, PT, Grothe, MJ & Buchert, R 2020, 'FDG Uptake in the Basal Forebrain as Measured by Digital High-Resolution PET Is a Promising Marker of Basal Forebrain Degeneration in the Lewy Body Disease Spectrum: A Pilot Study', CLIN NUCL MED, vol. 45, no. 4, pp. 261-266. https://doi.org/10.1097/RLU.0000000000002960

APA

Özden, C., Frings, L., Apostolova, I., Lange, C., Klutmann, S., Adam, G., Bannas, P., Meyer, P. T., Grothe, M. J., & Buchert, R. (2020). FDG Uptake in the Basal Forebrain as Measured by Digital High-Resolution PET Is a Promising Marker of Basal Forebrain Degeneration in the Lewy Body Disease Spectrum: A Pilot Study. CLIN NUCL MED, 45(4), 261-266. https://doi.org/10.1097/RLU.0000000000002960

Vancouver

Özden C, Frings L, Apostolova I, Lange C, Klutmann S, Adam G et al. FDG Uptake in the Basal Forebrain as Measured by Digital High-Resolution PET Is a Promising Marker of Basal Forebrain Degeneration in the Lewy Body Disease Spectrum: A Pilot Study. CLIN NUCL MED. 2020 Apr;45(4):261-266. https://doi.org/10.1097/RLU.0000000000002960

Bibtex

@article{f35ed9d0ffbc4fc78a059b6778f0eca1,
title = "FDG Uptake in the Basal Forebrain as Measured by Digital High-Resolution PET Is a Promising Marker of Basal Forebrain Degeneration in the Lewy Body Disease Spectrum: A Pilot Study",
abstract = "PURPOSE: Cognitive decline in diseases of the Lewy body spectrum (LBS) is linked to dysfunction/degeneration of the basal forebrain (BF). Assessment of glucose metabolism in the BF by FDG PET is hampered by the small size of the BF and limited spatial resolution of conventional PET. This pilot study tested the feasibility of assessing BF glucose metabolism by high-resolution digital PET (dPET).PATIENTS AND METHODS: The retrospective study included 12 LBS patients (61-86 years, 5 demented). Whole-brain stereotactic normalization to anatomical standard space was followed by local stereotactic normalization of a 7 × 7 × 7-cm box around the BF to a custom-made 1 × 1 × 1-mm FDG dPET template. FDG uptake was scaled voxelwise to mean FDG uptake in the pons. Scaled FDG uptake in the BF was compared between demented and nondemented LBS patients and tested for correlation with cortical FDG uptake.RESULTS: Scaled FDG uptake in the BF was significantly lower in demented compared with nondemented patients (1.14 ± 0.09 vs 1.25 ± 0.06, P = 0.031). Brain-wide voxel-based testing for correlations with scaled FDG uptake in the BF revealed a large cluster comprising medial and ventrolateral frontal cortex, anterior cingulate cortex, insular cortex, and striatum as well as smaller clusters in motor cortex and occipital cortex (P < 0.001, uncorrected).CONCLUSIONS: These results suggest that dementia-associated BF degeneration in LBS can be sensitively measured as reduced BF FDG uptake on dPET. More accurate delineation of the BF based on individual high-resolution MRI might be useful to make optimal use of improved spatial resolution of dPET and to correct for possible disease- and age-dependent partial volume effects.",
keywords = "Aged, Basal Forebrain/diagnostic imaging, Female, Fluorodeoxyglucose F18, Humans, Lewy Body Disease/diagnostic imaging, Male, Middle Aged, Pilot Projects, Positron-Emission Tomography/methods, Predictive Value of Tests, Radiopharmaceuticals",
author = "Cansu {\"O}zden and Lars Frings and Ivayla Apostolova and Catharina Lange and Susanne Klutmann and Gerhard Adam and Peter Bannas and Meyer, {Philipp T} and Grothe, {Michel J} and Ralph Buchert",
year = "2020",
month = apr,
doi = "10.1097/RLU.0000000000002960",
language = "English",
volume = "45",
pages = "261--266",
journal = "CLIN NUCL MED",
issn = "0363-9762",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - FDG Uptake in the Basal Forebrain as Measured by Digital High-Resolution PET Is a Promising Marker of Basal Forebrain Degeneration in the Lewy Body Disease Spectrum: A Pilot Study

AU - Özden, Cansu

AU - Frings, Lars

AU - Apostolova, Ivayla

AU - Lange, Catharina

AU - Klutmann, Susanne

AU - Adam, Gerhard

AU - Bannas, Peter

AU - Meyer, Philipp T

AU - Grothe, Michel J

AU - Buchert, Ralph

PY - 2020/4

Y1 - 2020/4

N2 - PURPOSE: Cognitive decline in diseases of the Lewy body spectrum (LBS) is linked to dysfunction/degeneration of the basal forebrain (BF). Assessment of glucose metabolism in the BF by FDG PET is hampered by the small size of the BF and limited spatial resolution of conventional PET. This pilot study tested the feasibility of assessing BF glucose metabolism by high-resolution digital PET (dPET).PATIENTS AND METHODS: The retrospective study included 12 LBS patients (61-86 years, 5 demented). Whole-brain stereotactic normalization to anatomical standard space was followed by local stereotactic normalization of a 7 × 7 × 7-cm box around the BF to a custom-made 1 × 1 × 1-mm FDG dPET template. FDG uptake was scaled voxelwise to mean FDG uptake in the pons. Scaled FDG uptake in the BF was compared between demented and nondemented LBS patients and tested for correlation with cortical FDG uptake.RESULTS: Scaled FDG uptake in the BF was significantly lower in demented compared with nondemented patients (1.14 ± 0.09 vs 1.25 ± 0.06, P = 0.031). Brain-wide voxel-based testing for correlations with scaled FDG uptake in the BF revealed a large cluster comprising medial and ventrolateral frontal cortex, anterior cingulate cortex, insular cortex, and striatum as well as smaller clusters in motor cortex and occipital cortex (P < 0.001, uncorrected).CONCLUSIONS: These results suggest that dementia-associated BF degeneration in LBS can be sensitively measured as reduced BF FDG uptake on dPET. More accurate delineation of the BF based on individual high-resolution MRI might be useful to make optimal use of improved spatial resolution of dPET and to correct for possible disease- and age-dependent partial volume effects.

AB - PURPOSE: Cognitive decline in diseases of the Lewy body spectrum (LBS) is linked to dysfunction/degeneration of the basal forebrain (BF). Assessment of glucose metabolism in the BF by FDG PET is hampered by the small size of the BF and limited spatial resolution of conventional PET. This pilot study tested the feasibility of assessing BF glucose metabolism by high-resolution digital PET (dPET).PATIENTS AND METHODS: The retrospective study included 12 LBS patients (61-86 years, 5 demented). Whole-brain stereotactic normalization to anatomical standard space was followed by local stereotactic normalization of a 7 × 7 × 7-cm box around the BF to a custom-made 1 × 1 × 1-mm FDG dPET template. FDG uptake was scaled voxelwise to mean FDG uptake in the pons. Scaled FDG uptake in the BF was compared between demented and nondemented LBS patients and tested for correlation with cortical FDG uptake.RESULTS: Scaled FDG uptake in the BF was significantly lower in demented compared with nondemented patients (1.14 ± 0.09 vs 1.25 ± 0.06, P = 0.031). Brain-wide voxel-based testing for correlations with scaled FDG uptake in the BF revealed a large cluster comprising medial and ventrolateral frontal cortex, anterior cingulate cortex, insular cortex, and striatum as well as smaller clusters in motor cortex and occipital cortex (P < 0.001, uncorrected).CONCLUSIONS: These results suggest that dementia-associated BF degeneration in LBS can be sensitively measured as reduced BF FDG uptake on dPET. More accurate delineation of the BF based on individual high-resolution MRI might be useful to make optimal use of improved spatial resolution of dPET and to correct for possible disease- and age-dependent partial volume effects.

KW - Aged

KW - Basal Forebrain/diagnostic imaging

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Lewy Body Disease/diagnostic imaging

KW - Male

KW - Middle Aged

KW - Pilot Projects

KW - Positron-Emission Tomography/methods

KW - Predictive Value of Tests

KW - Radiopharmaceuticals

U2 - 10.1097/RLU.0000000000002960

DO - 10.1097/RLU.0000000000002960

M3 - SCORING: Journal article

C2 - 32108697

VL - 45

SP - 261

EP - 266

JO - CLIN NUCL MED

JF - CLIN NUCL MED

SN - 0363-9762

IS - 4

ER -