Fate of large donor site defects in osteochondral transfer procedures in the knee joint with and without TruFit plugs
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Fate of large donor site defects in osteochondral transfer procedures in the knee joint with and without TruFit plugs. / Quarch, Verena M A; Enderle, Elena; Lotz, Joachim; Frosch, Karl-Heinz.
In: ARCH ORTHOP TRAUM SU, Vol. 134, No. 5, 05.2014, p. 657-66.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Fate of large donor site defects in osteochondral transfer procedures in the knee joint with and without TruFit plugs
AU - Quarch, Verena M A
AU - Enderle, Elena
AU - Lotz, Joachim
AU - Frosch, Karl-Heinz
PY - 2014/5
Y1 - 2014/5
N2 - INTRODUCTION: Because of the potential donor site morbidity, cartilage lesions of more than 3 cm(2) in size are considered to be critical regarding autologous osteochondral transplantation (OCT). In this study, the potential donor site morbidity for large defects should be reduced by means of OBI TruFit Plugs.MATERIALS AND METHODS: An autologous OCT was carried out on 37 patients and the cylinders were received from the dorsal medial femoral condyle. The donor site defects of 21 patients (average defect size 5.5 cm(2)) were filled with artificial TruFit cylinders (study group); the donor site defects (average defect size 4.6 cm(2)) were left untreated for 16 patients.RESULTS: In the study group, the Tegner, Western Ontario and McMaster Universities (WOMAC), knee society score, and visual analogue scale pain scores improved from preoperatively 3.2 (±0.8), 60.9 (±41.6), 133.6 (±27.1), and 4.8 (±2.3) points, respectively, to 3.9 (±0.6), 35.5 (±27.1), 177.8 (±16.6), and 3.3 (±2.9) points, respectively, at the time of the second follow-up; the control group's preoperative score values came to 2.8 (±0.9), 73.3 (±50.2), 123.8 (±41.5), and 5.3 (±2.7) points, respectively, and changed to 3.6 (±0.8), 41.4 (±28.8), 179.3 (±17.5), and 3.1 (±2.0) points, respectively, at the time of the second follow-up. The smaller the initial chondral defect was in the study group, the better the WOMAC score values became (p < 0.05). The modified Henderson score at the study group's donor sites improved from 19.2 (±3.3) to 13.7 (±2.1) points (p < 0.001); the control group's score values for the donor sites were 18.3 (±3.4) and 15.4 (±4.4) points (p = 0.0015).CONCLUSIONS: OCT is an effective therapy even for large chondral defects >3 cm(2). By filling the defects with TruFit implants, no clinical improvements could be found since the donor site morbidity was already low anyway. However, the regeneration of defects filled with TruFit implants took more than 2 years.
AB - INTRODUCTION: Because of the potential donor site morbidity, cartilage lesions of more than 3 cm(2) in size are considered to be critical regarding autologous osteochondral transplantation (OCT). In this study, the potential donor site morbidity for large defects should be reduced by means of OBI TruFit Plugs.MATERIALS AND METHODS: An autologous OCT was carried out on 37 patients and the cylinders were received from the dorsal medial femoral condyle. The donor site defects of 21 patients (average defect size 5.5 cm(2)) were filled with artificial TruFit cylinders (study group); the donor site defects (average defect size 4.6 cm(2)) were left untreated for 16 patients.RESULTS: In the study group, the Tegner, Western Ontario and McMaster Universities (WOMAC), knee society score, and visual analogue scale pain scores improved from preoperatively 3.2 (±0.8), 60.9 (±41.6), 133.6 (±27.1), and 4.8 (±2.3) points, respectively, to 3.9 (±0.6), 35.5 (±27.1), 177.8 (±16.6), and 3.3 (±2.9) points, respectively, at the time of the second follow-up; the control group's preoperative score values came to 2.8 (±0.9), 73.3 (±50.2), 123.8 (±41.5), and 5.3 (±2.7) points, respectively, and changed to 3.6 (±0.8), 41.4 (±28.8), 179.3 (±17.5), and 3.1 (±2.0) points, respectively, at the time of the second follow-up. The smaller the initial chondral defect was in the study group, the better the WOMAC score values became (p < 0.05). The modified Henderson score at the study group's donor sites improved from 19.2 (±3.3) to 13.7 (±2.1) points (p < 0.001); the control group's score values for the donor sites were 18.3 (±3.4) and 15.4 (±4.4) points (p = 0.0015).CONCLUSIONS: OCT is an effective therapy even for large chondral defects >3 cm(2). By filling the defects with TruFit implants, no clinical improvements could be found since the donor site morbidity was already low anyway. However, the regeneration of defects filled with TruFit implants took more than 2 years.
KW - Adult
KW - Age Factors
KW - Bone Transplantation
KW - Cartilage, Articular
KW - Female
KW - Femur
KW - Follow-Up Studies
KW - Humans
KW - Knee
KW - Knee Joint
KW - Male
KW - Middle Aged
KW - Ontario
KW - Pain Measurement
KW - Prostheses and Implants
KW - Prosthesis Implantation
KW - Retrospective Studies
KW - Tissue and Organ Harvesting
KW - Transplant Donor Site
KW - Transplantation, Autologous
KW - Wound Healing
KW - Comparative Study
KW - Journal Article
U2 - 10.1007/s00402-014-1930-y
DO - 10.1007/s00402-014-1930-y
M3 - SCORING: Journal article
C2 - 24488360
VL - 134
SP - 657
EP - 666
JO - ARCH ORTHOP TRAUM SU
JF - ARCH ORTHOP TRAUM SU
SN - 0936-8051
IS - 5
ER -