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Familial hemophagocytic lymphohistiocytosis: how late can the onset be?

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Familial hemophagocytic lymphohistiocytosis: how late can the onset be? / Allen, M; De Fusco, C; Legrand, F; Clementi, R; Conter, V; Danesino, C; Janka-Schaub, Gritta; Aricò, M.

In: HAEMATOLOGICA, Vol. 86, No. 5, 5, 2001, p. 499-503.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Allen, M, De Fusco, C, Legrand, F, Clementi, R, Conter, V, Danesino, C, Janka-Schaub, G & Aricò, M 2001, 'Familial hemophagocytic lymphohistiocytosis: how late can the onset be?', HAEMATOLOGICA, vol. 86, no. 5, 5, pp. 499-503. <http://www.ncbi.nlm.nih.gov/pubmed/11410413?dopt=Citation>

APA

Allen, M., De Fusco, C., Legrand, F., Clementi, R., Conter, V., Danesino, C., Janka-Schaub, G., & Aricò, M. (2001). Familial hemophagocytic lymphohistiocytosis: how late can the onset be? HAEMATOLOGICA, 86(5), 499-503. [5]. http://www.ncbi.nlm.nih.gov/pubmed/11410413?dopt=Citation

Vancouver

Allen M, De Fusco C, Legrand F, Clementi R, Conter V, Danesino C et al. Familial hemophagocytic lymphohistiocytosis: how late can the onset be? HAEMATOLOGICA. 2001;86(5):499-503. 5.

Bibtex

@article{0767bc3c66974a0f88ef8eba902759ff,
title = "Familial hemophagocytic lymphohistiocytosis: how late can the onset be?",
abstract = "BACKGROUND AND OBJECTIVES. Most patients with familial hemophagocytic lymphohistiocytosis (HLH) develop the disease within the first two years of age. In a minority of cases a later occurrence has been reported, with an upper age limit of eight years. A significant concordance of the age at onset within each family has also been observed. RESULTS. We report four cases of families with HLH diagnosed at an unusually late age, comprised between between 9 and 17 years; in each of these families another child developed the disease in infancy. The natural killer activity of the patients was depleted; nevertheless, we had indirect evidence that, in at least two families, mutations of the perforin gene were not causing the disease. INTERPRETATION AND CONCLUSIONS. Such a late onset is very unusual and suggests that there is a subgroup of families with HLH in which the disease may present early or late in different members. Thus in some families with HLH the siblings might remain at risk of developing the disease for several years. Their actual risk cannot be defined until the genetic mutation is identified in each family and assessed in each member.",
author = "M Allen and {De Fusco}, C and F Legrand and R Clementi and V Conter and C Danesino and Gritta Janka-Schaub and M Aric{\`o}",
year = "2001",
language = "Deutsch",
volume = "86",
pages = "499--503",
journal = "HAEMATOLOGICA",
issn = "0390-6078",
publisher = "Ferrata Storti Foundation",
number = "5",

}

RIS

TY - JOUR

T1 - Familial hemophagocytic lymphohistiocytosis: how late can the onset be?

AU - Allen, M

AU - De Fusco, C

AU - Legrand, F

AU - Clementi, R

AU - Conter, V

AU - Danesino, C

AU - Janka-Schaub, Gritta

AU - Aricò, M

PY - 2001

Y1 - 2001

N2 - BACKGROUND AND OBJECTIVES. Most patients with familial hemophagocytic lymphohistiocytosis (HLH) develop the disease within the first two years of age. In a minority of cases a later occurrence has been reported, with an upper age limit of eight years. A significant concordance of the age at onset within each family has also been observed. RESULTS. We report four cases of families with HLH diagnosed at an unusually late age, comprised between between 9 and 17 years; in each of these families another child developed the disease in infancy. The natural killer activity of the patients was depleted; nevertheless, we had indirect evidence that, in at least two families, mutations of the perforin gene were not causing the disease. INTERPRETATION AND CONCLUSIONS. Such a late onset is very unusual and suggests that there is a subgroup of families with HLH in which the disease may present early or late in different members. Thus in some families with HLH the siblings might remain at risk of developing the disease for several years. Their actual risk cannot be defined until the genetic mutation is identified in each family and assessed in each member.

AB - BACKGROUND AND OBJECTIVES. Most patients with familial hemophagocytic lymphohistiocytosis (HLH) develop the disease within the first two years of age. In a minority of cases a later occurrence has been reported, with an upper age limit of eight years. A significant concordance of the age at onset within each family has also been observed. RESULTS. We report four cases of families with HLH diagnosed at an unusually late age, comprised between between 9 and 17 years; in each of these families another child developed the disease in infancy. The natural killer activity of the patients was depleted; nevertheless, we had indirect evidence that, in at least two families, mutations of the perforin gene were not causing the disease. INTERPRETATION AND CONCLUSIONS. Such a late onset is very unusual and suggests that there is a subgroup of families with HLH in which the disease may present early or late in different members. Thus in some families with HLH the siblings might remain at risk of developing the disease for several years. Their actual risk cannot be defined until the genetic mutation is identified in each family and assessed in each member.

M3 - SCORING: Zeitschriftenaufsatz

VL - 86

SP - 499

EP - 503

JO - HAEMATOLOGICA

JF - HAEMATOLOGICA

SN - 0390-6078

IS - 5

M1 - 5

ER -