Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex.
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Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex. / Hummel, Friedhelm; Heise, Kirstin-Friederike; Celnik, Pablo; Floel, Agnes; Gerloff, Christian; Cohen, Leonardo G.
In: NEUROBIOL AGING, 2009.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex.
AU - Hummel, Friedhelm
AU - Heise, Kirstin-Friederike
AU - Celnik, Pablo
AU - Floel, Agnes
AU - Gerloff, Christian
AU - Cohen, Leonardo G
PY - 2009
Y1 - 2009
N2 - Healthy ageing is accompanied by limitations in performance of activities of daily living and personal independence. Recent reports demonstrated improvements in motor function induced by noninvasive anodal direct current stimulation (tDCS) of the primary motor cortex (M1) in young healthy adults. Here we tested the hypothesis that a single session of anodal tDCS over left M1 could facilitate performance of right upper extremity tasks required for activities of daily living (Jebsen-Taylor hand function test, JTT) in older subjects relative to Sham in a double-blind cross-over study design. We found (a) significant improvement in JTT function with tDCS relative to Sham that outlasted the stimulation period by at least 30min, (b) that the older the subjects the more prominent this improvement appeared and (c) that consistent with previous results in younger subjects, these effects were not accompanied by any overt undesired side effect. We conclude that anodal tDCS applied over M1 can facilitate performance of skilled hand functions required for activities of daily living in older subjects.
AB - Healthy ageing is accompanied by limitations in performance of activities of daily living and personal independence. Recent reports demonstrated improvements in motor function induced by noninvasive anodal direct current stimulation (tDCS) of the primary motor cortex (M1) in young healthy adults. Here we tested the hypothesis that a single session of anodal tDCS over left M1 could facilitate performance of right upper extremity tasks required for activities of daily living (Jebsen-Taylor hand function test, JTT) in older subjects relative to Sham in a double-blind cross-over study design. We found (a) significant improvement in JTT function with tDCS relative to Sham that outlasted the stimulation period by at least 30min, (b) that the older the subjects the more prominent this improvement appeared and (c) that consistent with previous results in younger subjects, these effects were not accompanied by any overt undesired side effect. We conclude that anodal tDCS applied over M1 can facilitate performance of skilled hand functions required for activities of daily living in older subjects.
M3 - SCORING: Zeitschriftenaufsatz
JO - NEUROBIOL AGING
JF - NEUROBIOL AGING
SN - 0197-4580
ER -